Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia

Disease Markers

Volumn 22, Issue 1-2, 2006, Pages 95-102

  Xiang, Zhongmin ^a   Haroutunian, Vahram ^a   Ho, Lap ^a   Purohit, Dushant ^a   Pasinetti, Giulio Maria ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer; Biomarker; Inflammation; Microglia; Proteomic

Indexed keywords

AMYLOID; BIOLOGICAL MARKER; HLA DR ANTIGEN;

AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAIN REGION; BRAIN TISSUE; CLINICAL EXAMINATION; CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMER DISEASE; CONTROLLED STUDY; DEMENTIA; DENTATE GYRUS; DISEASE CLASSIFICATION; DISEASE COURSE; ENCEPHALITIS; ENTORHINAL CORTEX; FEMALE; GRAY MATTER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; ORGANIZATION; PRIORITY JOURNAL; REGISTER; STATISTICAL SIGNIFICANCE; TISSUE SECTION; WHITE MATTER;

EID: 29244437580     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.1155/2006/276239     Document Type: Article

References (27)

1. P.S. Aisen, Inflammation and Alzheimer disease, Mol Chem Neuropathol 28 (1996), 83-88.
2. J. Bauer, G. Konig, S. Strauss et al., In-vitro matured human macrophages express Alzheimer's beta A4-amyloid precursor protein indicating synthesis in microglial cells, FEBS Lett 282 (1991), 335-340.
3. J.C. Breitner, Epidemiologic clues to the causes and routes to prevention of Alzheimer disease, J Neural Transm Suppl 59 (2000), 251-254.
4. C.A. Colton and D.L. Gilbert, Production of superoxide anions by a CNS macrophage, the microglia, FEBS Lett 223 (1987), 284-288.
5. C.W. Cotman, The beta-amyloid peptide, peptide self-assembly, and the emergence of biological activities. A new principle in peptide function and the induction of neuropathology, Ann N Y Acad Sci 814 (1997), 1-16.
6. D.A. Dzenko, R.B. Weltzien and J.S. Pachter, Suppression of A beta-induced monocyte neurotoxicity by antiinflammatory compounds, J Neuroimmunol 80 (1997), 6-12.
7. D. Giulian, J. Li, B. Leara and C. Keenen, Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture, Neurochem Int 25 (1994), 227-233.
8. V. Haroutunian, D.P. Purohit, D.P. Perl et al., Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease, Arch Neurol 56 (1999), 713-718.
9. L. Ho, D. Purohit, V. Haroutunian et al., Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease, Arch Neurol 58 (2001), 487-492.
10. J.D. Luterman, V. Haroutunian, S. Yemul et al., Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia, Arch. Neurol. 57 (2000), 1153-1160.
11. L.A. Mattiace, P. Davies and D.W. Dickson, Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors, Am J Pathol 136 (1990), 1101-1114.
12. P.L. McGeer, H. Akiyama, S. Itagaki and E.G. McGeer, Immune system response in Alzheimer's disease, Can J Neurol Sci 16 (1989), 516-527.
13. P.L. McGeer, S. Itagaki, H. Tago and E.G. McGeer, Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR, Neurosci Lett 79 (1987), 195-200.
14. S.S. Mirra, Neuropathological assessment of Alzheimer's disease: the experience of the Consortium to Establish a Registry for Alzheimer's Disease, Int Psychogeriatr 9(1) (1997), 263-268.
15. K, Miura, S. Baba, H. Shirasawa, S.T. Ju, A.S. Cohen and T. Shirahama, Intraperitoneal amyloid formation by amyloid enhancing factor-rich macrophages in ascitic fluid, Virchows Arch B Cell Pathol Incl Mol Pathol 62 (1992), 245-250.
16. G.M. Pasinetti, Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: the role of the complement system, Neurobiol Aging 17 (1996), 707-716.
17. G.M. Pasinetti, Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions, J Neurosci Res 54 (1998), 1-6.
18. G.M. Pasinetti and P.S. Aisen, Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain, Neuroscience 87 (1998), 319-324.
19. J.M. Rozemuller, V. van d and P. Eikelenboom, Activated microglia and cerebral amyloid deposits in Alzheimer's disease, Res Immunol 143 (1992), 646-649.
20. M. Sawada, N. Kondo, A. Suzumura and T. Marunouchi, Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res 491 (1989), 394-397.
21. L.G. Sheffield, J.G. Marquis and N.E. Berman, Regional distribution of cortical microglia parallels that of neurofibrillary tangles in Alzheimer's disease, Neurosci Lett 285 (2000), 165-168.
22. S.D. Styren, W.H. Civin and J. Rogers, Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain, Exp Neurol 110 (1990), 93-104.
23. D.R. Thal, T. Arendt, G. Waldmann et al., Progression of neurofibrillary changes and PHF-tau in end-stage Alzheimer's disease is different from plaque and cortical microglial pathology, Neurobiol Aging 19 (1998), 517-552.
24. S. Webster, L.F. Lue, L. Brachova et al., Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease, Neurobiol Aging 18 (1997), 415-421.
25. S.L. Wesselingh, K. Takahashi, J.D. Glass, J.C. McArthur, J.W. Griffin and D.E. Griffin, Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistochemistry, J Neuroimmunol 74 (1997), 1-8.
26. H.M. Wisniewski and J. Wegiel, The role of microglia in amyloid fibril formation, Neuropathol Appl Neurobiol 20 (1994), 192-194.
27. J. Yao, J.E. Keri, R.E. Taffs and C.A. Colton, Characterization of interleukin-1 production by microglia in culture. Brain Res 591 (1992), 88-93.