In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks

Acta Neuropathologica

Volumn 121, Issue 3, 2011, Pages 327-335

  Burgold, Steffen ^a   Bittner, Tobias ^a   Dorostkar, Mario M ^a   Kieser, Daniel ^b   Fuhrmann, Martin ^a   Mitteregger, Gerda ^a   Kretzschmar, Hans ^a   Schmidt, Boris ^b   Herms, Jochen ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Electronic Materials Division   (Germany)

Author keywords

A , plaque growth; Alzheimer's disease; Amyloid plaque; Imaging; In vivo; Tg2576; Two photon

Indexed keywords

FLUORESCENT DYE; METHOXY X04; UNCLASSIFIED DRUG;

AGE; AMYLOID PLAQUE; AMYLOID PLAQUE GROWTH; AMYLOID PLAQUE VOLUME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FLUORESCENCE IMAGING; GROWTH RATE; IMAGE PROCESSING; MONITORING; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STAINING; THREE DIMENSIONAL IMAGING; TRANSGENIC MOUSE; TWO PHOTON IN VIVO IMAGING;

AGING; ALZHEIMER DISEASE; AMYLOID; ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; PLAQUE, AMYLOID;

EID: 79954449798     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0787-6     Document Type: Article

References (24)

1. Bittner T, Fuhrmann M, Burgold S et al (2009) gamma-Secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. J Neurosci 29:10405-10409
2. Bolmont T, Haiss F, Eicke D et al (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J Neurosci 28:4283-4292
3. Christie RH, Bacskai BJ, Zipfel WR et al (2001) Growth arrest of individual senile plaques in amodel of Alzheimer's disease observed by in vivo multiphoton microscopy. J Neurosci 21:858-864 (Pubitemid 32163127)
4. Esler WP, Stimson ER, Ghilardi JR et al (1996) In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics. Biochemistry 35:749-757
5. Feng G, Mellor RH, Bernstein M et al (2000) Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28:41-51
6. Fuhrmann M, Bittner T, Jung C K E et al (2010) Microglial CX3CR1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci 13:411-413
7. Grutzendler J, Helmin K, Tsai J, Gan WB (2007) Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease. Ann NY Acad Sci 1097:30-39 (Pubitemid 47084880)
8. Holtmaat A, Bonhoeffer T, Chow DK et al (2009) Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window. Nat Protocols 4:1128-1144
9. Hsiao K, Chapman P, Nilsen S et al (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102 (Pubitemid 26332733)
10. Hsieh H, Boehm J, Sato C et al (2006) AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 52:831-843 (Pubitemid 44828454)
11. Jarrett JT, Lansbury PT (1993) Seeding one-dimensional crystallization of amyloid-a pathogenic mechanism in Alzheimer's disease and scrapie. Cell 73:1055-1058 (Pubitemid 23180480)
12. Kadir A, Almkvist O, Forsberg A et al (2010) Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease. Neurobiol Aging. doi:10.1016/j.neurobiolaging.2010.06.015
13. Klunk WE, Bacskai BJ, Mathis CA et al (2002) Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol 61:797-805 (Pubitemid 35001352)
14. Knafo S, Alonso-Nanclares L, Gonzalez-Soriano J et al (2009) Widespread changes in dendritic spines in a model of Alzheimer's disease. Cereb Cortex 19:586-592
15. Koffie RM, Meyer-Luehmann M, Hashimoto T et al (2009) Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci USA 106:4012-4017
16. Meyer-Luehmann M, Spires-Jones TL, Prada C et al (2008) Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 451:720-724 (Pubitemid 351220570)
17. Shankar GM, Li SM, Mehta TH et al (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14:837-842
18. Snyder EM, Nong Y, Almeida CG et al (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 8:1051-1058 (Pubitemid 41061516)
19. Spires TL, Meyer-Luehmann M, Stern EA et al (2005) Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci 25:7278-7287 (Pubitemid 41113944)
20. Spires-Jones TL, Meyer-Luehmann M, Osetek JD et al (2007) Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. Am J Pathol 171:1304-1311 (Pubitemid 47582903)
21. Tsai J, Grutzendler J, Duff K, Gan WB (2004) Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci 7:1181-1183 (Pubitemid 39426234)
22. Wadell H (1935) Volume, shape, and roundness of quartz particles. J Geol 43:250-280
23. Wei W, Nguyen LN, Kessels HW et al (2010) Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci 13:190-196
24. Yan P, Bero AW, Cirrito JR et al (2009) Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice. J Neurosci 29:10706-10714