Non-viral nanoparticle delivers small interfering RNA to macrophages in vitro and in vivo

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Zhang, Mei ^a,b   Gao, Yunxiang ^c   Caja, Kevin ^a,b   Zhao, Bocheng ^a,b   Kim, Julian A ^a,b,d  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c Case Western Reserve University   (United States)

^d UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROPHAGE MIGRATION INHIBITION FACTOR; MESSENGER RNA; NANOPARTICLE; SMALL INTERFERING RNA; ISOMERASE; MIF PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BREAST TUMOR; COLORIMETRY; CONTROLLED STUDY; CYTOPLASM; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MACROPHAGE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; GENETICS; HUMAN; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; HUMANS; IN VITRO TECHNIQUES; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MACROPHAGES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; NANOPARTICLES; RNA, SMALL INTERFERING;

EID: 84925709891     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118472     Document Type: Article

References (46)

1. Barros MHM, Hauck F, Dreyer JH, Kempkes B, Niedobitek G. Macrophage Polarisation: an immunohistochemical Approach for Identifying M1 and M2 Macrophages. PLoS ONE. 2013; 8: 80908-80915.
2. Siveen KS, Kuttan G. Role of Macrophages in Tumour Progression. Immunol. Lett. 2009; 123: 97-102. doi: 10.1016/j.imlet.2009.02.011 PMID: 19428556
3. Coffelt SB, Hughes R, Lewis CE. Tumor-Associated Macrophages: Effectors of Angiogenesis and Tumor Progression. Biochim. Biophys. Acta. 2009; 1796: 11-18. doi: 10.1016/j.bbcan.2009.02.004 PMID: 19269310
4. Kambal A, Mitchell G, Cary W, Gruenloh W, Jung Y, Kalomoiris S, et al. Generation of HIV-1 Resistant and Functional Macrophages From Hematopoietic Stem Cell-derived Induced Pluripotent Stem Cells. Mol. Ther. 2011; 19: 584-593. doi: 10.1038/mt.2010.269 PMID: 21119622
5. Fernandez-Boyanapalli R. Impaired Phagocytosis of Apoptotic Cells by Macrophages in Chronic Granulomatous Disease is Reversed by IFN-gamma in a Nitric Oxide-Dependent Manner. J. Immunol. 2010; 185: 4030-4041. doi: 10.4049/jimmunol.1001778 PMID: 20805415
6. Wilson HM, Macrophages Heterogeneity in Atherosclerosis-Implications for Therapy. J. Cell Mol. Med. 2010; 14: 2055-2065. doi: 10.1111/j.1582-4934.2010.01121.x PMID: 20629993
7. Olefsky JM, Glass CK. Macrophages, Inflammation, and Insulin Resistance. Annu. Rev. Physiol. 2010; 72: 219-246. doi: 10.1146/annurev-physiol-021909-135846 PMID: 20148674
8. Gordon S. The Macrophage: Past, Present and Future. Eur. J. Immunol. 2007; 1: 9-17.
9. Ovchinnikov DA. Macrophages in the Embryo and Beyond: Much More Than Just Giant Phagocytes. Genesis. 2008; 46: 447-462. doi: 10.1002/dvg.20417 PMID: 18781633
10. Pecot CV, Calin GA, Coleman RL, Lopez-Berestein G, Sood AK. RNA Interference In the Clinic: Challenges and Future Directions. Nat. Rev. Cancer. 2011; 11: 59-67. doi: 10.1038/nrc2966 PMID: 21160526
11. Zhang X, Edwards JP, Mosser DM. The Expression of Exogenous Genes in Macrophages: Obstacles and Opportunities. Methods Mol. Biol. 2009; 531: 123-143. doi: 10.1007/978-1-59745-396-7-9 PMID: 19347315
12. Semple SC. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010; 28:172-176. doi: 10.1038/nbt.1602 PMID: 20081866
13. Basha G. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol. Ther. 2011; 19:2186-2200. doi: 10.1038/mt.2011.190 PMID: 21971424
14. Love KT. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci. 2010; 107:1864-9.29. doi: 10.1073/pnas.0910603106 PMID: 20080679
15. Chao Y, Karmali PP, Simberg D. Role of carbohydrate receptors in the macrophage uptake of dextrancoated iron oxide nanoparticles. Adv Exp Med Biol 2012; 733:115-123. doi: 10.1007/978-94-007-2555-3-11 PMID: 22101717
16. Leuschner F. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 2011; 29:1005-1010. doi: 10.1038/nbt.1989 PMID: 21983520
17. Courties G. In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol 2014; 63:1556-1566. doi: 10.1016/j.jacc.2013.11.023 PMID: 24361318
18. Zhang M, Kim J. Effect of Molecular Size and Modification Pattern on The Internalization of Water Soluble β-(1→3)-(1→4)-Glucan by Primary Murine Macrophages. Intern. J. Biochem. Cell Bio. 2012; 44: 14-21.
19. Nishihira J, Ishibashi T, Fukushima T, Sun B, Sato Y, Todo S. Macrophage migration inhibitory factor (MIF): Its potential role in tumor growth and tumor-associated angiogenesis. Annals of the New York Academy of Sciences. 2003; 995: 171-178. PMID: 12814949
20. Bifulco C, McDaniel K, Leng L, Bucala R. Tumor growth promoting properties of macrophage migration inhibitory factor. Current Pharmaceutical Design. 2008; 14: 3790-3801. PMID: 19128232
21. Bach JP, Rinn B, Meyer B, Dodel R, Bacher M. Role of MIF in inflammation and tumorigenesis. Oncology. 2008; 75: 127-133.
22. Verjins E, Noetzel E, Bektal N, Schutz A, Lue H, Lennartz B, et al. Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. BMC Cancer. 2009; 9:230-238.
23. Larson DF, Horak K. Macrophage migration inhibitory factor: controller of systemic inflammation. Critical Care, 2006; 10: 138-146.
24. Price S. Connective tissue diseases: small-molecule inhibitor of MIF protects lupus-prone mice from kidney disease. Nat Rev Rheumatol 2011; 7: 70-74.
25. Beduneau A, Ma Z, Grotepas CB, Kabanov A, Rabinow BE. Facilitated Monocyte-Macrophage Uptake and Tissue Distribution of Superparmagnetic Iron-Oxide Nanoparticles. PLoS ONE. 2009; 4: 4343-4346
26. Al Faraj A, Sultana Shaik A, Pureza MA, Alnafea M, Halwani R. Preferential Macrophage Recruitment and Polarization in LPS-Induced Animal Model for COPD: Noninvasive Tracking Using MRI. PLoS ONE. 2014; 9: 90829-90835. doi: 10.1371/journal.pone.0090829 PMID: 24598763
27. Rinaudo M. Main Properties and Current Applications of Some Polysaccharides as Biomaterials. Polym. Intern. 2008; 57: 33-39.
28. Hu Y, Ding Y, Ge H, Yuan Y, Yang C. Synthesis and Characterization of Chitosan-Poly(Acrylic Acid) Nanoparticles. Biomaterials. 2002; 23: 8-14.
29. Zhang N, Wardwell PR, Bader RA. Polysaccharide-based micelles for drug delivery. Pharmaceutics. 2013; 5: 329-352.
30. Pelosi L, Imai T, Chanzy H, Heux L, Buhler E, Bulone V. Structural and morphological diversity of (1-3)-beta-D-glucans synthesized in vitro by enzymes from Saprolegnia monoica. Biochemistry. 2003; 42: 6264-6274. PMID: 12755631
31. Rudzinski W, Aminabhavi TM. Chitosan As a Carrier For Targeted Delivery of Small Interfering RNA. Int. J. Pharm. 2010; 399: 1-11. doi: 10.1016/j.ijpharm.2010.08.022 PMID: 20732398
32. Kang JH. Liver-Targeted siRNA Delivery by Polyethylenimine (PEI)-Pullulan Carrier. Bioorg. Med. Chem. 2010; 18: 3946-3950. doi: 10.1016/j.bmc.2010.04.031 PMID: 20472444
33. Bloomfield VA. DNA condensation by multivalent cations. Biopolymers 1997; 44: 269-282. PMID: 9591479
34. Song H. Cationic lipid-coated PEI/DNA polyplexes with improved efficiency and reduced cytotoxicity for gene delivery into mesenchymal stem cells. Int J Nanomedicine 2012; 7:4637-4648. doi: 10.2147/IJN.S33923 PMID: 22942645
35. Dominska M, Dykxhoorn D.M. Breaking down the barriers: siRNA delivery and endosome escape. J Cell Sci. 2010; 123: 1183-1189. doi: 10.1242/jcs.066399 PMID: 20356929
36. Wilson R.C., Doudna J.A. Molecular Mechanisms of RNA Interference. Annual Review of Biophysics 2013; 42: 217-239 doi: 10.1146/annurev-biophys-083012-130404 PMID: 23654304
37. Pires LR. Imidazole-grafted chitosan-mediated gene delivery: in vitro study on transfection, intracellular trafficking and degradation. Nanomedicine 2011; 6:1499-1512. doi: 10.2217/nnm.11.51 PMID: 22011312
38. Bartlett DW, Davis ME. Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res. 2006; 34: 322-333. PMID: 16410612
39. Yoshimori T, Moriyama Y, Futai M, Tashiro Y. Bafilomycin A1, A Specific Inhibitor of Vacuolar-Type H (+)-ATPase, Inhibits Acidification and Protein Degradation in Lysosomes of Cultured Cells. J. Bio. Chem. 1991; 266: 17707-17713. PMID: 1832676
40. Faure AM, Sanchez-Ferrer A, Zabara A, Andersen ML, Nystrom L. Modulating the structural properties of beta-D-glucan degradation products by alternative reaction pathways. Carbohydr Polym. 2014; 99: 679-686. doi: 10.1016/j.carbpol.2013.08.022 PMID: 24274558
41. Pan B, Trout BL. A Molecular Mechanism of Hydrolysis of Peptide Bonds at Neutral pH. J. Phys. Chem. B. 2011; 115: 12-19.
42. Muta T. Molecular basis for invertebrate innate immune recognition of (1->3)-beta-D-glucan as a pathogen-associated molecular pattern. Curr Pharm Des 2006; 12: 4155-4161. PMID: 17100618
43. Jokerst J, Lobovkina T, Zare R, Gambhir S. Nanoparticle PEGylation for Imaging and Therapy. Nanomedicine. 2011; 6: 715-728. doi: 10.2217/nnm.11.19 PMID: 21718180
44. Lue H, Kleemann R, Calandra T, Roger T, Bernhagen J. Macrophage Migration Inhibitory Factor (MIF): Mechanisms of Action and Role in Disease. Microbes Infect. 2002; 4: 449-460. PMID: 11932196
45. Bando H, Matsumoto G, Bando M, Muta M, Ogawa T, Funata N, et al. Expression of Macrophage Migration Inhibitory Factor in Human Breast Cancer: Association with Nodal Spread. Jpn. J. Cancer. Res. 2002; 93: 389-396. PMID: 11985788
46. Xia Y, Zheng MY, Ting-Ting Rong, Yuan X, Ma Y, Wang Z, et al. CD74 and Macrophage Migration Inhibitory Factor as Therapeutic Targets in Gastric Cancer. World. J. Gastroenterol. 2012; 18: 9-17.