Cationic lipid-coated PEI/DNA polyplexes with improved efficiency and reduced cytotoxicity for gene delivery into mesenchymal stem cells

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 4637-4648

  Song, Hongmei ^a   Wang, Gang ^a   He, Bin ^a   Li, Li ^a   Li, Caixia ^a   Lai, Yusi ^a   Xu, Xianghui ^a   Gu, Zhongwei ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Bone marrow stem cells; Cationic lipids; Gene delivery; Lipopolyplex; Nonviral vectors; Polyethylenimine

Indexed keywords

ARGININE; CATION; CHOLESTEROL; DNA; HISTIDINE; LIPID; LUCIFERASE; LYSINE; MACROGOL; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG COATING; LIPID ANALYSIS; MESENCHYMAL STEM CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHYSICAL CHEMISTRY; PLASMID; PROCESS DEVELOPMENT; RAT;

AMINO ACIDS, ESSENTIAL; ANIMALS; BONE MARROW CELLS; CATIONS; CELL SURVIVAL; CHOLESTEROL; DNA; FLOW CYTOMETRY; INTRACELLULAR SPACE; LIPOSOMES; LUCIFERASES, FIREFLY; MESENCHYMAL STROMAL CELLS; MICROSCOPY, CONFOCAL; PARTICLE SIZE; PLASMIDS; POLYETHYLENEIMINE; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84868120308     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S33923     Document Type: Article

References (44)

1. Asahara T, Murohara T, Sullivan A, etal. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275(5302): 964-967.
2. Si YL, Zhao YL, Hao HJ, Fu XB, Han WD. MSCs: biological characteristics, clinical applications and their outstanding concerns. Ageing Res Rev. 2011;10(1):93-103.
3. Davis ME. Non-viral gene delivery systems. Curr Opin Biotechnol. 2002;13(2):128-131.
4. Santos JL, Pandita D, Rodrigues J, Pêgo AP, Granja PL, Tomás H. Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration. Curr Gene Ther. 2011;11(1):46-57.
5. Hu YL, Fu YH, Tabata Y, Gao JQ. Mesenchymal stem cells: a promising targeted-delivery vehicle in cancer gene therapy. J Control Release. 2010;147(2):154-162.
6. Godbey WT, Wu KK, Mikos AG. Poly(ethylenimine) and its role in gene delivery. J Control Release. 1999;60(2-3):149-160.
7. Godbey WT, Wu KK, Mikos AG. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc Natl Acad Sci U S A. 1999;96(9):5177-5181.
8. Clamme JP. Intracellular dynamics of the gene delivery vehicle polyethylenimine during transfection: investigation by two-photon fluorescence correlation spectroscopy. Biochim Biophys Acta. 2003;1617(1-2): 52-61.
9. Guo W, Lee RJ. Efficient gene delivery via non-covalent complexes of folic acid and polyethylenimine. J Control Release. 2001;77(1-2): 131-138.
10. Gao X, Kim KS, Liu D. Nonviral gene delivery: what we know and what is next. AAPS J. 2007;9(1):E92-E104.
11. Merdan T, Kopecek J, Kissel T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv Drug Deliv Rev. 2002; 54(5):715-758.
12. Lv H, Zhang S, Wang B, Cui S, Yan J. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release. 2006;114(1): 100-109.
13. Godbey WT, Barry MA, Saggau P, Wu KK, Mikos AG. Poly(ethylenimine)-mediated transfection: a new paradigm for gene delivery. J Biomed Mater Res A. 2000;51(3):321-328.
14. Fischer D, Bieber T, Li Y, Elsässer HP, Kissel T. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res. 1999;16(8):1273-1279.
15. Zhu W, Chen J, Cong X, Hu S, Chen X. Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Stem Cells. 2006;24(2): 416-425.
16. Chen XA, Zhang LJ, He ZJ, etal. Plasmid-encapsulated polyethylene glycol-grafted polyethylenimine nanoparticles for gene delivery into rat mesenchymal stem cells. Int J Nanomedicine. 2011;6:843-853.
17. Saraf A, Hacker MC, Sitharaman B, Grande-Allen KJ, Barry MA, Mikos AG. Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules. 2008;9(3):818-827.
18. He W, Guo Z, Wen Y, etal. Alginate-graft-PEI as a gene delivery vector with high efficiency and low cytotoxicity. J Biomater Sci Polym Ed. 2012;23(1-4):315-331.
19. Pelisek J, Gaedtke L, DeRouchey J, Walker GF, Nikol S, Wagner E. Optimized lipopolyplex formulations for gene transfer to human colon carcinoma cells under in vitro conditions. J Gene Med. 2006;8(2): 186-197.
20. García L, Buñuales M, Düzgüneş N, Tros de Ilarduya C. Serum-resistant lipopolyplexes for gene delivery to liver tumour cells. Eur J Pharm Biopharm. 2007;67(1):58-66.
21. Matsumoto M, Kishikawa R, Kurosaki T, etal. Hybrid vector including polyethylenimine and cationic lipid, DOTMA, for gene delivery. Int J Pharm. 2008;363(1-2):58-65.
22. Schäfer J, Höbel S, Bakowsky U, Aigner A. Liposome-polyethylenimine complexes for enhanced DNA and siRNA delivery. Biomaterials. 2010;31(26):6892-6900.
23. Lee CH, Ni YH, Chen CC, Chou C, Chang FH. Synergistic effect of polyethylenimine and cationic liposomes in nucleic acid delivery to human cancer cells. Biochim Biophys Acta. 2003;1611(1-2):55-62.
24. Lampela P, Elomaa M, Ruponen M, Urtti A, Männistö PT, Raasmaja A. Different synergistic roles of small polyethylenimine and Dosper in gene delivery. J Control Release. 2003;88(1):173-183.
25. Li L, Song H, Luo K, etal. Gene transfer efficacies of serum-resistant amino acids-based cationic lipids: dependence on headgroup, lipoplex stability and cellular uptake. Int J Pharm. 2011;408(1-2):183-190.
26. Li L, Nie Y, Zhu R, etal. Preparation and gene delivery of alkaline amino acids-based cationic liposomes. Arch Pharm Res. 2008;31(7): 924-931.
27. Menon LG, Picinich S, Koneru R, etal. Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells. Stem Cells. 2007;25(2): 520-528.
28. Ji J, Fu J, Shen J. Fabrication of a superhydrophobic surface from the amplified exponential growth of a multilayer. Adv Mater. 18(11): 1441-1444.
29. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) Method. Methods. 2001;25(4):402-408.
30. Ozawa CR, Banfi A, Glazer NL, etal. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest. 2004;113(4):516-527.
31. Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnol Bioeng. 2000;67(5):598-606.
32. Yue Y, Jin F, Deng R, etal. Revisit complexation between DNA and polyethylenimine-effect of uncomplexed chains free in the solution mixture on gene transfection. J Control Release. 2011;155(1):67-76.
33. Finsinger D, Remy JS, Erbacher P, Koch C, Plank C. Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery. Gene Ther. 2000;7(14):1183-1192.
34. Clamme JP, Azoulay J, Mély Y. Monitoring of the formation and dissociation of polyethylenimine/DNA complexes by two photon fluorescence correlation spectroscopy. Biophys J. 2003;84(3):1960-1968.
35. Yue Y, Jin F, Deng R, etal. Revisit complexation between DNA and polyethylenimine-effect of length of free polycationic chains on gene transfection. J Control Release. 152(1):143-151.
36. Boeckle S, von Gersdorff K, van der Piepen S, Culmsee C, Wagner E, Ogris M. Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer. J Gene Med. 2004;6(10): 1102-1111.
37. Erbacher P, Bettinger T, Brion E, etal. Genuine DNA/polyethylenimine (PEI) complexes improve transfection properties and cell survival. J Drug Target. 2004;12(4):223-236.
38. Guo W, Lee RJ. Efficient gene delivery via non-covalent complexes of folic acid and polyethylenimine. J Control Release. 2001;77(1-2): 131-138.
39. Guo W, Lee RJ. Efficient gene delivery using anionic liposome-complexed polyplexes (LPDII). Biosci Rep. 2000;20(5):419-432.
40. Wasungu L, Hoekstra D. Cationic lipids, lipoplexes and intracellular delivery of genes. J Control Release. 2006;116(2):255-264.
41. Dastan T, Turan K. In vitro characterization and delivery of chitosan-DNA microparticles into mammalian cells. J Pharm Pharm Sci. 2004;7(2):205-214.
42. Chen J, Yu Z, Chen H, Gao J, Liang W. Transfection efficiency and intracellular fate of polycation liposomes combined with protamine. Biomaterials. 2011;32(5):1412-1418.
43. Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T, Dawson KA. Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc Natl Acad Sci U S A. 2008;105(38):14265-14270.
44. Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol. 1999;237:1-30.