Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner

Stem Cells

Volumn 33, Issue 4, 2015, Pages 1320-1332

  He, Xi Biao ^a,b   Kim, Mirang ^b   Kim, Seon Young ^b   Yi, Sang Hoon ^a,b   Rhee, Yong Hee ^a,b   Kim, Taeho ^a,b   Lee, Eun Hye ^b,c   Park, Chang Hwan ^b,c   Dixit, Shilpy ^d   Harrison, Fiona E ^d   Lee, Sang Hun ^a,b,c  

^a Hanyang University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

5hmC; Dopamine neuron; Fetal midbrain; Jmjd3; Vitamin C

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; ASCORBIC ACID; HISTONE H3; JMJD3 PROTEIN; NUCLEAR RECEPTOR RELATED FACTOR 1; PROTEIN; SODIUM ASCORBIC ACID COTRANSPORTER; SODIUM DEPENDENT VITAMIN C TRANSPORTER 2; TET1 PROTEIN; UNCLASSIFIED DRUG; DIOXYGENASE; HISTONE DEMETHYLASE; JMJD3 PROTEIN, RAT; TET1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; BINDING SITE; BRAIN DEVELOPMENT; CATALYSIS; CONTROLLED STUDY; DNA METHYLATION; DOPAMINERGIC NERVE CELL; EMBRYO; EPIGENETICS; FETUS; GENE CONTROL; GENE SILENCING; GENETIC TRANSCRIPTION; KNOCKOUT MOUSE; MESENCEPHALON; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; PARKINSON DISEASE; PRESYNAPTIC NERVE; PROMOTER REGION; PROTEIN EXPRESSION; RAT; STEM CELL; STEM CELL CULTURE; VENTRAL MIDBRAIN; VITAMIN SUPPLEMENTATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENETIC EPIGENESIS; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ASCORBIC ACID; CELL DIFFERENTIATION; CELLS, CULTURED; DIOXYGENASES; DOPAMINERGIC NEURONS; EPIGENESIS, GENETIC; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROGENESIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84925651386     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1932     Document Type: Article

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