메뉴 건너뛰기




Volumn 6, Issue 11, 2014, Pages

Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: A new direction for bacteriology

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIOLOGY; COMPUTER PROGRAM; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; GENOMICS; HUMAN; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; POPULATION STRUCTURE; PRIORITY JOURNAL; REVIEW; STATISTICAL ANALYSIS;

EID: 84925624433     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/s13073-014-0109-z     Document Type: Review
Times cited : (86)

References (86)
  • 1
    • 77956636824 scopus 로고    scopus 로고
    • Genome-wide association studies: a primer
    • 19895722
    • Corvin A, Craddock N, Sullivan PF. Genome-wide association studies: a primer. Psychol Med 2010, 40:1063-1077. 10.1017/S0033291709991723, 19895722.
    • (2010) Psychol Med , vol.40 , pp. 1063-1077
    • Corvin, A.1    Craddock, N.2    Sullivan, P.F.3
  • 6
    • 33746556194 scopus 로고    scopus 로고
    • Genome-wide association mapping in bacteria?
    • 16782339
    • Falush D, Bowden R. Genome-wide association mapping in bacteria?. Trends Microbiol 2006, 14:353-355. 10.1016/j.tim.2006.06.003, 16782339.
    • (2006) Trends Microbiol , vol.14 , pp. 353-355
    • Falush, D.1    Bowden, R.2
  • 7
    • 0033402241 scopus 로고    scopus 로고
    • Multilocus sequence typing
    • 10603483
    • Enright MC, Spratt BG. Multilocus sequence typing. Trends Microbiol 1999, 7:482-487. 10.1016/S0966-842X(99)01609-1, 10603483.
    • (1999) Trends Microbiol , vol.7 , pp. 482-487
    • Enright, M.C.1    Spratt, B.G.2
  • 8
    • 0037772204 scopus 로고    scopus 로고
    • Microarrays for bacterial detection and microbial community analysis
    • 12831906
    • Zhou J. Microarrays for bacterial detection and microbial community analysis. Curr Opin Microbiol 2003, 6:288-294. 10.1016/S1369-5274(03)00052-3, 12831906.
    • (2003) Curr Opin Microbiol , vol.6 , pp. 288-294
    • Zhou, J.1
  • 9
    • 0036718055 scopus 로고    scopus 로고
    • Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus
    • 12183545
    • Peacock SJ, Moore CE, Justice A, Kantzanou M, Story L, Mackie K, O'Neill G, Day NPJ. Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus. Infect Immun 2002, 70:4987-4996. 10.1128/IAI.70.9.4987-4996.2002, 12183545.
    • (2002) Infect Immun , vol.70 , pp. 4987-4996
    • Peacock, S.J.1    Moore, C.E.2    Justice, A.3    Kantzanou, M.4    Story, L.5    Mackie, K.6    O'Neill, G.7    Day, N.P.J.8
  • 11
    • 33646596541 scopus 로고    scopus 로고
    • Application of comparative phylogenomics to study the evolution of Yersinia enterocolitica and to identify genetic differences relating to pathogenicity
    • 16672618
    • Howard SL, Gaunt MW, Hinds J, Witney AA, Stabler R, Wren BW. Application of comparative phylogenomics to study the evolution of Yersinia enterocolitica and to identify genetic differences relating to pathogenicity. J Bacteriol 2006, 188:3645-3653. 10.1128/JB.188.10.3645-3653.2006, 16672618.
    • (2006) J Bacteriol , vol.188 , pp. 3645-3653
    • Howard, S.L.1    Gaunt, M.W.2    Hinds, J.3    Witney, A.A.4    Stabler, R.5    Wren, B.W.6
  • 12
    • 42549144495 scopus 로고    scopus 로고
    • Molecular correlates of host specialization in Staphylococcus aureus
    • 17971880
    • Herron-Olson L, Fitzgerald JR, Musser JM, Kapur V. Molecular correlates of host specialization in Staphylococcus aureus . PLoS One 2007, 2:e1120. 10.1371/journal.pone.0001120, 17971880.
    • (2007) PLoS One , vol.2 , pp. e1120
    • Herron-Olson, L.1    Fitzgerald, J.R.2    Musser, J.M.3    Kapur, V.4
  • 15
    • 70350220595 scopus 로고    scopus 로고
    • Genotyping technologies for genetic research
    • 19453250
    • Ragoussis J. Genotyping technologies for genetic research. Annu Rev Genomics Hum Genet 2009, 10:117-133. 10.1146/annurev-genom-082908-150116, 19453250.
    • (2009) Annu Rev Genomics Hum Genet , vol.10 , pp. 117-133
    • Ragoussis, J.1
  • 22
    • 23944475626 scopus 로고    scopus 로고
    • Mechanisms of, and barriers to, horizontal gene transfer between bacteria
    • 16138099
    • Thomas CM, Nielsen KM. Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat Rev Microbiol 2005, 3:711-721. 10.1038/nrmicro1234, 16138099.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 711-721
    • Thomas, C.M.1    Nielsen, K.M.2
  • 24
    • 61349194462 scopus 로고    scopus 로고
    • Estimating the size of the bacterial pan-genome
    • 19168257
    • Lapierre P, Gogarten JP. Estimating the size of the bacterial pan-genome. Trends Genet 2009, 25:107-110. 10.1016/j.tig.2008.12.004, 19168257.
    • (2009) Trends Genet , vol.25 , pp. 107-110
    • Lapierre, P.1    Gogarten, J.P.2
  • 25
    • 0035479142 scopus 로고    scopus 로고
    • Deletional bias and the evolution of bacterial genomes
    • 11585665
    • Mira A, Ochman H, Moran NA. Deletional bias and the evolution of bacterial genomes. Trends Genet 2001, 17:589-596. 10.1016/S0168-9525(01)02447-7, 11585665.
    • (2001) Trends Genet , vol.17 , pp. 589-596
    • Mira, A.1    Ochman, H.2    Moran, N.A.3
  • 26
    • 79251573854 scopus 로고    scopus 로고
    • Inference of homologous recombination in bacteria using whole-genome sequences
    • 20923983
    • Didelot X, Lawson D, Darling A, Falush D. Inference of homologous recombination in bacteria using whole-genome sequences. Genetics 2010, 186:1435-1449. 10.1534/genetics.110.120121, 20923983.
    • (2010) Genetics , vol.186 , pp. 1435-1449
    • Didelot, X.1    Lawson, D.2    Darling, A.3    Falush, D.4
  • 27
    • 77954143123 scopus 로고    scopus 로고
    • Impact of recombination on bacterial evolution
    • 20452218
    • Didelot X, Maiden MC. Impact of recombination on bacterial evolution. Trends Microbiol 2010, 18:315-322. 10.1016/j.tim.2010.04.002, 20452218.
    • (2010) Trends Microbiol , vol.18 , pp. 315-322
    • Didelot, X.1    Maiden, M.C.2
  • 28
    • 84855193674 scopus 로고    scopus 로고
    • Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages
    • 21540364
    • Somboonna N, Wan R, Ojcius DM, Pettengill MA, Joseph SJ, Chang A, Hsu R, Read TD, Dean D. Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages. MBio 2011, 2:e00045-11. 10.1128/mBio.00045-11, 21540364.
    • (2011) MBio , vol.2
    • Somboonna, N.1    Wan, R.2    Ojcius, D.M.3    Pettengill, M.A.4    Joseph, S.J.5    Chang, A.6    Hsu, R.7    Read, T.D.8    Dean, D.9
  • 29
    • 65449117702 scopus 로고    scopus 로고
    • Looking for Darwin's footprints in the microbial world
    • 19375326
    • Shapiro BJ, David LA, Friedman J, Alm EJ. Looking for Darwin's footprints in the microbial world. Trends Microbiol 2009, 17:196-204. 10.1016/j.tim.2009.02.002, 19375326.
    • (2009) Trends Microbiol , vol.17 , pp. 196-204
    • Shapiro, B.J.1    David, L.A.2    Friedman, J.3    Alm, E.J.4
  • 30
    • 19944429215 scopus 로고    scopus 로고
    • Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in central Japan
    • 15616287
    • Ito M, Deguchi T, Mizutani K-S, Yasuda M, Yokoi S, Ito S-I, Takahashi Y, Ishihara S, Kawamura Y, Ezaki T. Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in central Japan. Antimicrob Agents Chemother 2005, 49:137-143. 10.1128/AAC.49.1.137-143.2005, 15616287.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 137-143
    • Ito, M.1    Deguchi, T.2    Mizutani, K.-S.3    Yasuda, M.4    Yokoi, S.5    Ito, S.-I.6    Takahashi, Y.7    Ishihara, S.8    Kawamura, Y.9    Ezaki, T.10
  • 34
    • 84901447428 scopus 로고    scopus 로고
    • Efficient inference of recombination hot regions in bacterial genomes
    • 24586045
    • Yahara K, Didelot X, Ansari MA, Sheppard SK, Falush D. Efficient inference of recombination hot regions in bacterial genomes. Mol Biol Evol 2014, 31:1593-1605. 10.1093/molbev/msu082, 24586045.
    • (2014) Mol Biol Evol , vol.31 , pp. 1593-1605
    • Yahara, K.1    Didelot, X.2    Ansari, M.A.3    Sheppard, S.K.4    Falush, D.5
  • 35
    • 84869012626 scopus 로고    scopus 로고
    • Population genomics of Chlamydia trachomatis: insights on drift, selection, recombination, and population structure
    • 22891032
    • Joseph SJ, Didelot X, Rothschild J, de Vries HJC, Morré SA, Read TD, Dean D. Population genomics of Chlamydia trachomatis: insights on drift, selection, recombination, and population structure. Mol Biol Evol 2012, 29:3933-3946. 10.1093/molbev/mss198, 22891032.
    • (2012) Mol Biol Evol , vol.29 , pp. 3933-3946
    • Joseph, S.J.1    Didelot, X.2    Rothschild, J.3    de Vries, H.J.C.4    Morré, S.A.5    Read, T.D.6    Dean, D.7
  • 39
    • 77958598599 scopus 로고    scopus 로고
    • Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study
    • 20842694
    • Sebro R, Hoffman TJ, Lange C, Rogus JJ, Risch NJ. Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study. Genet Epidemiol 2010, 34:674-679. 10.1002/gepi.20528, 20842694.
    • (2010) Genet Epidemiol , vol.34 , pp. 674-679
    • Sebro, R.1    Hoffman, T.J.2    Lange, C.3    Rogus, J.J.4    Risch, N.J.5
  • 40
    • 67149095078 scopus 로고    scopus 로고
    • Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip
    • 19492015
    • Spencer CCA, Su Z, Donnelly P, Marchini J. Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet 2009, 5:e1000477. 10.1371/journal.pgen.1000477, 19492015.
    • (2009) PLoS Genet , vol.5
    • Spencer, C.C.A.1    Su, Z.2    Donnelly, P.3    Marchini, J.4
  • 41
    • 77953811255 scopus 로고    scopus 로고
    • New approaches to population stratification in genome-wide association studies
    • 20548291
    • Price AL, Zaitlen NA, Reich D, Patterson N. New approaches to population stratification in genome-wide association studies. Nat Rev Genet 2010, 11:459-463. 10.1038/nrg2813, 20548291.
    • (2010) Nat Rev Genet , vol.11 , pp. 459-463
    • Price, A.L.1    Zaitlen, N.A.2    Reich, D.3    Patterson, N.4
  • 42
    • 84901545323 scopus 로고    scopus 로고
    • Forward genetic approaches in Chlamydia trachomatis
    • Nguyen BD, Valdivia RH. Forward genetic approaches in Chlamydia trachomatis . J Vis Exp 2013, 23:e50636.
    • (2013) J Vis Exp , vol.23
    • Nguyen, B.D.1    Valdivia, R.H.2
  • 47
    • 84891935788 scopus 로고    scopus 로고
    • When whole-genome alignments just won't work: kSNP v2 software for alignment-free SNP discovery and phylogenetics of hundreds of microbial genomes
    • 24349125
    • Gardner SN, Hall BG. When whole-genome alignments just won't work: kSNP v2 software for alignment-free SNP discovery and phylogenetics of hundreds of microbial genomes. PLoS One 2013, 8:e81760. 10.1371/journal.pone.0081760, 24349125.
    • (2013) PLoS One , vol.8
    • Gardner, S.N.1    Hall, B.G.2
  • 48
    • 84899548242 scopus 로고    scopus 로고
    • Automated reconstruction of whole-genome phylogenies from short-sequence reads
    • 24600054
    • Bertels F, Silander OK, Pachkov M, Rainey PB, van Nimwegen E. Automated reconstruction of whole-genome phylogenies from short-sequence reads. Mol Biol Evol 2014, 31:1077-1088. 10.1093/molbev/msu088, 24600054.
    • (2014) Mol Biol Evol , vol.31 , pp. 1077-1088
    • Bertels, F.1    Silander, O.K.2    Pachkov, M.3    Rainey, P.B.4    van Nimwegen, E.5
  • 50
    • 76049108917 scopus 로고    scopus 로고
    • ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure
    • 20137780
    • Thornton T, McPeek MS. ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure. Am J Hum Genet 2010, 86:172-184. 10.1016/j.ajhg.2010.01.001, 20137780.
    • (2010) Am J Hum Genet , vol.86 , pp. 172-184
    • Thornton, T.1    McPeek, M.S.2
  • 51
    • 84896520688 scopus 로고    scopus 로고
    • SNP-associations and phenotype predictions from hundreds of microbial genomes without genome alignments
    • 24587377
    • Hall BG. SNP-associations and phenotype predictions from hundreds of microbial genomes without genome alignments. PLoS One 2014, 9:e90490. 10.1371/journal.pone.0090490, 24587377.
    • (2014) PLoS One , vol.9
    • Hall, B.G.1
  • 52
    • 84898786106 scopus 로고    scopus 로고
    • Statistical power and significance testing in large-scale genetic studies
    • 24739678
    • Sham PC, Purcell SM. Statistical power and significance testing in large-scale genetic studies. Nat Rev Genet 2014, 15:335-346. 10.1038/nrg3706, 24739678.
    • (2014) Nat Rev Genet , vol.15 , pp. 335-346
    • Sham, P.C.1    Purcell, S.M.2
  • 53
    • 12244264435 scopus 로고    scopus 로고
    • Genetic power calculator: design of linkage and association genetic mapping studies of complex traits
    • 12499305
    • Purcell S, Cherny SS, Sham PC. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003, 19:149-150. 10.1093/bioinformatics/19.1.149, 12499305.
    • (2003) Bioinformatics , vol.19 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sham, P.C.3
  • 54
    • 78651530238 scopus 로고    scopus 로고
    • GWAPower: a statistical power calculation software for genome-wide association studies with quantitative traits
    • 21255436
    • Feng S, Wang S, Chen C-C, Lan L. GWAPower: a statistical power calculation software for genome-wide association studies with quantitative traits. BMC Genet 2011, 12:12. 10.1186/1471-2156-12-12, 21255436.
    • (2011) BMC Genet , vol.12 , pp. 12
    • Feng, S.1    Wang, S.2    Chen, C.-C.3    Lan, L.4
  • 55
    • 79957951017 scopus 로고    scopus 로고
    • Low-coverage sequencing: implications for design of complex trait association studies
    • 21460063
    • Li Y, Sidore C, Kang HM, Boehnke M, Abecasis GR. Low-coverage sequencing: implications for design of complex trait association studies. Genome Res 2011, 21:940-951. 10.1101/gr.117259.110, 21460063.
    • (2011) Genome Res , vol.21 , pp. 940-951
    • Li, Y.1    Sidore, C.2    Kang, H.M.3    Boehnke, M.4    Abecasis, G.R.5
  • 56
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • 12883005
    • Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003, 100:9440-9445. 10.1073/pnas.1530509100, 12883005.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 57
    • 84925608282 scopus 로고    scopus 로고
    • A phylogeny-based sampling strategy and power calculator informs genome-wide associations study design for microbial pathogens
    • Farhat MR, Shapiro BS, Sheppard SK, Colijn C, Murray M. A phylogeny-based sampling strategy and power calculator informs genome-wide associations study design for microbial pathogens. Genome Med 2014, 6:101. 10.1186/s13073-014-0101-7.
    • (2014) Genome Med , vol.6 , pp. 101
    • Farhat, M.R.1    Shapiro, B.S.2    Sheppard, S.K.3    Colijn, C.4    Murray, M.5
  • 59
    • 40349106161 scopus 로고    scopus 로고
    • The landscape of human proteins interacting with viruses and other pathogens
    • 18282095
    • Dyer M, Murali T, Sobral B. The landscape of human proteins interacting with viruses and other pathogens. PLoS Pathog 2008, 4:e32. 10.1371/journal.ppat.0040032, 18282095.
    • (2008) PLoS Pathog , vol.4
    • Dyer, M.1    Murali, T.2    Sobral, B.3
  • 60
    • 70349611730 scopus 로고    scopus 로고
    • Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms
    • 19767758
    • Van Opijnen T, Bodi KL, Camilli A. Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms. Nat Methods 2009, 6:767-772. 10.1038/nmeth.1377, 19767758.
    • (2009) Nat Methods , vol.6 , pp. 767-772
    • Van Opijnen, T.1    Bodi, K.L.2    Camilli, A.3
  • 61
    • 77957802374 scopus 로고    scopus 로고
    • Studying bacterial transcriptomes using RNA-seq
    • 20888288
    • Croucher NJ, Thomson NR. Studying bacterial transcriptomes using RNA-seq. Curr Opin Microbiol 2010, 13:619-624. 10.1016/j.mib.2010.09.009, 20888288.
    • (2010) Curr Opin Microbiol , vol.13 , pp. 619-624
    • Croucher, N.J.1    Thomson, N.R.2
  • 62
    • 57449100870 scopus 로고    scopus 로고
    • Design and analysis of ChIP-seq experiments for DNA-binding proteins
    • 19029915
    • Kharchenko PV, Tolstorukov MY, Park PJ. Design and analysis of ChIP-seq experiments for DNA-binding proteins. Nat Biotechnol 2008, 26:1351-1359. 10.1038/nbt.1508, 19029915.
    • (2008) Nat Biotechnol , vol.26 , pp. 1351-1359
    • Kharchenko, P.V.1    Tolstorukov, M.Y.2    Park, P.J.3
  • 63
    • 84875264746 scopus 로고    scopus 로고
    • Staphylococcal superantigens in colonization and disease
    • 22919643
    • Xu SX, McCormick JK. Staphylococcal superantigens in colonization and disease. Front Cell Infect Microbiol 2012, 2:52. 22919643.
    • (2012) Front Cell Infect Microbiol , vol.2 , pp. 52
    • Xu, S.X.1    McCormick, J.K.2
  • 64
    • 84875806740 scopus 로고    scopus 로고
    • Salmonella T3SSs: successful mission of the secret(ion) agents
    • 23295139
    • Moest TP, Méresse S. Salmonella T3SSs: successful mission of the secret(ion) agents. Curr Opin Microbiol 2013, 16:38-44. 10.1016/j.mib.2012.11.006, 23295139.
    • (2013) Curr Opin Microbiol , vol.16 , pp. 38-44
    • Moest, T.P.1    Méresse, S.2
  • 65
    • 0024041593 scopus 로고
    • Molecular Koch's Postulates applied to microbial pathogenicity
    • 3055197
    • Falkow S. Molecular Koch's Postulates applied to microbial pathogenicity. Rev Infect Dis 1988, 10:S274-S276. 10.1093/cid/10.Supplement_2.S274, 3055197.
    • (1988) Rev Infect Dis , vol.10 , pp. S274-S276
    • Falkow, S.1
  • 66
    • 84874638650 scopus 로고    scopus 로고
    • A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes
    • e00537-12 23404398
    • Fey PD, Endres JL, Yajjala VK, Widhelm TJ, Boissy RJ, Bose JL, Bayles KW. A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes. MBio 2013, 4:e00537-12. 10.1128/mBio.00537-12, 23404398.
    • (2013) MBio , vol.4
    • Fey, P.D.1    Endres, J.L.2    Yajjala, V.K.3    Widhelm, T.J.4    Boissy, R.J.5    Bose, J.L.6    Bayles, K.W.7
  • 69
    • 84888774923 scopus 로고    scopus 로고
    • Microbiology. Genomes from metagenomics
    • 24288324
    • Sharon I, Banfield JF. Microbiology. Genomes from metagenomics. Science 2013, 342:1057-1058. 10.1126/science.1247023, 24288324.
    • (2013) Science , vol.342 , pp. 1057-1058
    • Sharon, I.1    Banfield, J.F.2
  • 71
    • 34248373709 scopus 로고    scopus 로고
    • Laboratory strains of Escherichia coli: model citizens or deceitful delinquents growing old disgracefully?
    • 17501914
    • Hobman JL, Penn CW, Pallen MJ. Laboratory strains of Escherichia coli: model citizens or deceitful delinquents growing old disgracefully?. Mol Microbiol 2007, 64:881-885. 10.1111/j.1365-2958.2007.05710.x, 17501914.
    • (2007) Mol Microbiol , vol.64 , pp. 881-885
    • Hobman, J.L.1    Penn, C.W.2    Pallen, M.J.3
  • 73
    • 0032588014 scopus 로고    scopus 로고
    • Regulation of sigmaB-dependent transcription of sigB and asp23 in two different Staphylococcus aureus strains
    • 10323238
    • Gertz S, Engelmann S, Schmid R, Ohlsen K, Hacker J, Hecker M. Regulation of sigmaB-dependent transcription of sigB and asp23 in two different Staphylococcus aureus strains. Mol Gen Genet 1999, 261:558-466. 10.1007/s004380051001, 10323238.
    • (1999) Mol Gen Genet , vol.261 , pp. 558-1466
    • Gertz, S.1    Engelmann, S.2    Schmid, R.3    Ohlsen, K.4    Hacker, J.5    Hecker, M.6
  • 75
    • 73149103718 scopus 로고    scopus 로고
    • Prioritizing GWAS results: a review of statistical methods and recommendations for their application
    • 20074509
    • Cantor RM, Lange K, Sinsheimer JS. Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am J Hum Genet 2010, 86:6-22. 10.1016/j.ajhg.2009.11.017, 20074509.
    • (2010) Am J Hum Genet , vol.86 , pp. 6-22
    • Cantor, R.M.1    Lange, K.2    Sinsheimer, J.S.3
  • 76
    • 84890546613 scopus 로고    scopus 로고
    • Systems genetics approaches to understand complex traits
    • 24296534
    • Civelek M, Lusis AJ. Systems genetics approaches to understand complex traits. Nat Rev Genet 2014, 15:34-48. 10.1038/nrg3575, 24296534.
    • (2014) Nat Rev Genet , vol.15 , pp. 34-48
    • Civelek, M.1    Lusis, A.J.2
  • 79
    • 84865231395 scopus 로고    scopus 로고
    • Transforming clinical microbiology with bacterial genome sequencing
    • 22868263
    • Didelot X, Bowden R, Wilson DJ, Peto TEA, Crook DW. Transforming clinical microbiology with bacterial genome sequencing. Nat Rev Genet 2012, 13:601-612. 10.1038/nrg3226, 22868263.
    • (2012) Nat Rev Genet , vol.13 , pp. 601-612
    • Didelot, X.1    Bowden, R.2    Wilson, D.J.3    Peto, T.E.A.4    Crook, D.W.5
  • 81
    • 77957769655 scopus 로고    scopus 로고
    • High-throughput sequencing and clinical microbiology: progress, opportunities and challenges
    • 20843733
    • Pallen MJ, Loman NJ, Penn CW. High-throughput sequencing and clinical microbiology: progress, opportunities and challenges. Curr Opin Microbiol 2010, 13:625-631. 10.1016/j.mib.2010.08.003, 20843733.
    • (2010) Curr Opin Microbiol , vol.13 , pp. 625-631
    • Pallen, M.J.1    Loman, N.J.2    Penn, C.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.