Testing for non-random mating: Evidence for ancestry-related assortative mating in the Framingham heart study

Genetic Epidemiology

Volumn 34, Issue 7, 2010, Pages 674-679

  Sebro, Ronnie ^a,b   Hoffman, Thomas J ^a   Lange, Christoph ^c,d,e   Rogus, John J ^f   Risch, Neil J ^a,b,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF BONN   (Germany)

^e GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^f JOSLIN DIABETES CENTER   (United States)

^g DIVISION OF RESEARCH   (United States)

Author keywords

Hardy Weinberg equilibrium; Non random mating; Population stratification

Indexed keywords

ARTICLE; ASSORTATIVE MATING; CAUCASIAN; EUROPEAN AMERICAN; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MATING; POPULATION GENETICS; POPULATION RESEARCH; PRINCIPAL COMPONENT ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SPOUSE;

ALLELES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; HEART DISEASES; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MASSACHUSETTS; MODELS, GENETIC; MOLECULAR EPIDEMIOLOGY; POLYMORPHISM, SINGLE NUCLEOTIDE; PRINCIPAL COMPONENT ANALYSIS; SPOUSES;

EID: 77958598599     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20528     Document Type: Article

References (16)

1. Burrell AS, Disotell TR. 2009. Panmixia postponed: ancestry-related assortative mating in contemporary human populations. Genome Biol 10:245.
2. Campbell CD, Ogburn EL, Lunetta KL, Lyon HN, Freedman ML, Groop LC, Altshuler D, Ardlie KG, Hirschhorn JN. 2005. Demonstrating stratification in a European American population. Nat Genet 37:868-872.
3. Cotterman CW, Snyder LH. 1937. Studies in human inheritance XVII gene frequency analysis of double recessive inheritance involving one autosomal and one sex linked gene. Genetica 19:537-552.
4. Cupples LA, Arruda HT, Benjamin EJ, D'Agostino Sr RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q, Atwood LD. National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA. The Framingham Heart Study 100K SNP genome/wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet 8(Suppl 1):S1.
5. Dawber TR, Moore Jr FE, Mann GV. 1957. Coronary heart disease in the Framingham Study. Am J Public Health 47:4-24.
6. Devlin B, Roeder K. 1999. Genomic control for association studies. Biometrics 55:997-1004.
7. Elandt-Johnson RC. 1971. Probability Models and Statistical Methods in Genetics. New York: Wiley.
8. Haldane JBS. 1954. An exact test for randomness of mating. J Genet 52:631-635.
9. Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A, Riley J, Purvis I, Xu CF. 2004. Detection of genotyping errors by Hardy-Weinberg equilibrium testing. Eur J Hum Genet 12:395-399.
10. Leal SM. 2005. Detection of genotyping errors and pseudo-SNPs via deviations from Hardy-Weinberg equilibrium. Genet Epidemiol 29:204-214.
11. Lewontin RC, Hartl DL. 1991. Population genetics in forensic DNA typing. Science 254:1745-1750.
12. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. 2006. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38:904-909.
13. Risch N, Choudhry S, Via M, Basu A, Sebro R, Eng C, Beckman K, Thyne S, Chapela R, Rodriguez-Santana JR, Rodriguez-Cintron W, Avila PC, Ziv E, Gonzalez Burchard E. 2009. Ancestry-related assortative mating in Latino populations. Genome Biol 10:R132.
14. Tian C, Plenge RM, Ransom M, Lee A, Villoslada P, Selmi C, Klareskog L, Pulver AE, Qi L, Gregersen PK, Seldin MF. 2008 Analysis and application of European genetic substructure using 300 K SNP information. PLoS Genet 4:e4.
15. Yasuda N. 1968. An extension of Wahlund's principle to evaluate mating type frequency. Am J Hum Genet 20:1-23.
16. Zou G, Pan D, Zhao H. 2003. Genotyping error detection through tightly linked markers. Genetics 164:1161-1173.