Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade

ACS Nano

Volumn 8, Issue 9, 2014, Pages 8776-8785

  Lin, Kevin Y ^a   Lo, Justin H ^b,c   Consul, Nikita ^a   Kwong, Gabriel A ^b   Bhatia, Sangeeta N ^b,d,e,f,g  

^a Department of Chemical Engineering ^*  (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f Department of Electrical Engineering and Computer Science   (United States)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

anticoagulation; nanomedicine; protease; self regulation; stimuli responsive

Indexed keywords

COAGULATION; DISEASE CONTROL; FEEDBACK; MEDICAL NANOTECHNOLOGY; PATIENT TREATMENT; PEPTIDES;

ANTI-COAGULATION; HOMEOSTATIC REGULATIONS; LIFE THREATENING CONDITIONS; NEGATIVE FEEDBACK MECHANISM; NEGATIVE FEEDBACK REGULATORS; PROTEASE; SELF REGULATION; STIMULI-RESPONSIVE;

DISEASES;

ANTICOAGULANT AGENT; HEPARIN; MACROGOL DERIVATIVE; NANOMATERIAL;

ANIMAL; BLOOD CLOTTING; BOVINE; CHEMISTRY; DRUG EFFECTS; HOMEOSTASIS; HUMAN; MOUSE; PULMONARY EMBOLISM; SECRETION (PROCESS); THROMBOSIS; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; CATTLE; HEPARIN; HOMEOSTASIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; NANOSTRUCTURES; POLYETHYLENE GLYCOLS; PULMONARY EMBOLISM; THROMBOSIS;

EID: 84925610145     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn501129q     Document Type: Article

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