miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells

Oncotarget

Volumn 6, Issue 8, 2015, Pages 6014-6028

  Gao, Rui ^a   Cai, Chunli ^a   Gan, Jiancheng ^a   Yang, Xi ^a   Shuang, Zeyu ^b   Liu, Min ^a   Li, Shengping ^b   Tang, Hua ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

AFP; Hepatocellular cancer; microRNA; MicroRNA 1236; PTEN

Indexed keywords

ALPHA FETOPROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 1236; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; AFP PROTEIN, HUMAN; MIRN1236 MICRORNA, HUMAN; PTEN PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUMOR INVASION; TUMOR VASCULARIZATION; UBIQUITINATION; UPREGULATION; ANIMAL; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HEP-G2 CELL LINE; LIVER TUMOR; METABOLISM; NUDE MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ALPHA-FETOPROTEINS; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; HEK293 CELLS; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MICE; MICE, NUDE; MICRORNAS; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84925606417     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3338     Document Type: Article

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