Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis

Gastroenterology

Volumn 139, Issue 4, 2010, Pages

  Ko, Frankie Chi Fat ^a,b   Chan, Lo Kong ^a,b   Tung, Edmund Kwok Kwan ^a,b   Lowe, Scott W ^c,d   Ng, Irene Oi Lin ^a,b   Yam, Judy Wai Ping ^a,b  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Akt; Deleted in Liver Cancer 1; Hepatocellular Carcinoma; Phosphorylation

Indexed keywords

ALANINE; DELETED IN LIVER CANCER 1 PROTEIN; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; DLC1 PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; STARD13 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE ACTIVITY; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CANCER; LIVER CARCINOGENESIS; LIVER DEVELOPMENT; MALE; MALIGNANT TRANSFORMATION; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA TRANSLATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TUMOR SUPPRESSOR GENE; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CELL TRANSFORMATION; LIVER NEOPLASMS; NEOPLASM METASTASIS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; GTPASE-ACTIVATING PROTEINS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR SUPPRESSOR PROTEINS;

EID: 77957372620     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.06.051     Document Type: Article

References (37)

1. B.Z. Yuan, M.J. Miller, and C.L. Keck Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP Cancer Res 58 1998 2196 2199
2. M.E. Durkin, B.Z. Yuan, and X. Zhou DLC-1:a Rho GTPase-activating protein and tumour suppressor J Cell Mol Med 11 2007 1185 1207
3. A. Lahoz, and A. Hall DLC1: a significant GAP in the cancer genome Genes Dev 22 2008 1724 1730
4. L.K. Chan, F.C.F. Ko, and I.O.L. Ng Deleted in liver cancer 1 (DLC1) utilizes a previously undocumented binding site for tensin2 PTB domain interaction and required for tumor suppressive function PLoS ONE 4 2009 e5572
5. Y.C. Liao, L. Si, and R.W. deVere White The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1 J Cell Biol 176 2007 43 49
6. X. Qian, G. Li, and H.K. Asmussen Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities Proc Natl Acad Sci U S A 104 2007 9012 9017
7. C.M. Wong, J.W. Yam, and Y.P. Ching Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma Cancer Res 65 2005 8861 8868
8. J.W. Yam, F.C. Ko, and C.Y. Chan Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression Cancer Res 66 2006 8367 8372
9. I.O. Ng, Z.D. Liang, and L. Cao DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1 Cancer Res 60 2000 6581 6584
10. B.Z. Yuan, M.E. Durkin, and N.C. Popescu Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers Cancer Genet Cytogenet 140 2003 113 117
11. B.Z. Yuan, A.M. Jefferson, and K.T. Baldwin DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas Oncogene 23 2004 1405 1411
12. X. Zhou, S.S. Thorgeirsson, and N.C. Popescu Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells Oncogene 23 2004 1308 1313
13. S. Goodison, J. Yuan, and D. Sloan The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells Cancer Res 65 2005 6042 6053
14. T.Y. Kim, K.D. Healy, and C.J. Der Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration J Biol Chem 283 2008 32762 32770
15. K.D. Healy, L. Hodgson, and T.Y. Kim DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms Mol Carcinog 47 2008 326 337
16. J. Heering, P. Erlmann, and M.A. Olayioye Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration Exp Cell Res 315 2009 2505 2514
17. G. Holeiter, J. Heering, and P. Erlmann Deleted in liver cancer 1 controls cell migration through a Dia1-dependent signaling pathway Cancer Res 68 2008 8743 8751
18. W. Xue, A. Krasnitz, and R. Lucito DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma Genes Dev 22 2008 1439 1444
19. M. Guan, X. Zhou, and N. Soulitzis Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications Clin Cancer Res 12 2006 1412 1419
20. M. Plaumann, S. Seitz, and R. Frege Analysis of DLC-1 expression in human breast cancer J Cancer Res Clin Oncol 129 2003 349 354
21. F.C. Ko, Y.S. LeYeunge, and C.M. Wong Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma Liver Int 30 2010 139 148
22. C.M. Wong, J.M. Lee, and Y.P. Ching Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma Cancer Res 63 2003 7646 7651
23. Y.C. Liao, Y.P. Shih, and S.H. Lo Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function Cancer Res 68 2008 7718 7722
24. R.P. Scholz, J. Regner, and A. Theil DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling J Cell Sci 122 2009 92 102
25. I. Hers, M. Wherlock, and Y. Homma Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells J Biol Chem 281 2006 4762 4770
26. B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274
27. J.D. Carpten, A.L. Faber, and C. Horn A transforming mutation in the pleckstrin homology domain of AKT1 in cancer Nature 448 2007 439 444
28. J.W. Yam, F.C. Ko, and C.Y. Chan Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma Hepatology 44 2006 881 890
29. M.E. Durkin, V. Ullmannova, and M. Guan Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is down-regulated in cancer and inhibits tumor cell growth Oncogene 26 2007 4580 4589
30. T.Y. Kim, J.W. Lee, and H.P. Kim DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma Biochem Biophys Res Commun 355 2007 72 77
31. T.J. Seng, J.S. Low, and H. Li The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation Oncogene 26 2007 934 944
32. K.J. Schmitz, J. Wohlschlaeger, and H. Lang Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection J Hepatol 48 2008 83 90
33. D.A. Altomare, and J.R. Testa Perturbations of the AKT signaling pathway in human cancer Oncogene 24 2005 7455 7464
34. C.C. Wong, C.M. Wong, and F.C. Ko Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma PLoS ONE 3 2008 e2779
35. K.D. Healy, L. Hodgson, and T.Y. Kim DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms Mol Carcinog 47 2008 326 337
36. L. Zender, M.S. Spector, and W. Xue Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach Cell 125 2006 1253 1267
37. L.K. Chan, F.C.F. Ko, and I.O.L. Ng Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function PLoS ONE 4 2009 e5572