DUSP5 and DUSP6 modulate corneal epithelial cell proliferation

Molecular Vision

Volumn 16, Issue , 2010, Pages 1696-1704

  Wang, Zheng ^a   Reinach, Peter S ^a   Zhang, Fan ^a   Vellonen, Kati Sisko ^b   Urtti, Arto ^b   Turner, Helen ^c,d   Mario Wolosin, J ^c  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d Department of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 10; DUAL SPECIFICITY PHOSPHATASE 5; DUAL SPECIFICITY PHOSPHATASE 6; LENTIVIRUS VECTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA EPITHELIUM; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MICROARRAY ANALYSIS; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STEADY STATE;

CELL LINE, TRANSFORMED; CELL PROLIFERATION; DENSITOMETRY; DUAL SPECIFICITY PHOSPHATASE 1; DUAL SPECIFICITY PHOSPHATASE 6; DUAL-SPECIFICITY PHOSPHATASES; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VECTORS; HUMANS; LENTIVIRUS; PHOSPHORYLATION; THYMIDINE; TRANSDUCTION, GENETIC;

EID: 77956963274     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995; 9:726-735.
2. Treisman R. Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 1996; 8:205-215.
3. Tibbles LA, Woodgett JR. The stress-activated protein kinase pathways. Cell Mol Life Sci 1999; 55:1230-1254.
4. Chang L, Karin M. Mammalian MAP kinase signaling cascades. Nature 2001; 410:37-40.
5. Chambard JC, Lefloch R, Pouysségur J, Lenormand P. ERK implication in cell cycle regulation. Biochim Biophys Acta 2007; 1773:1299-1310.
6. Zehorai E, Yao Z, Plotnikov A, Seger R. The subcellular localization of MEK and ERK-a novel nuclear translocation signal (NTS) paves a way to the nucleus. Mol Cell Endocrinol 2010; 314:213-220.
7. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouysségur J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 1999; 18:664-674.
8. Jeffrey KL, Camps M, Rommel C, Mackay CR. Targeting dualspecificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat Rev Drug Discov 2007; 6:391-403.
9. Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev 2008; 27:253-261.
10. Patterson KI, Brummer T, O'Brien PM, Daly RJ. Dualspecificity phosphatases: critical regulators with diverse cellular targets. Biochem J 2009; 418:475-489.
11. Mandl M, Slack DN, Keyse SM. Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5. Mol Cell Biol 2005; 25:1830-1845.
12. Slack DN, Seternes OM, Gabrielsen M, Keyse SM. Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. J Biol Chem 2001; 276:16491-16500.
13. Arkell RS, Dickinson RJ, Squires M, Hayat S, Keyse SM, Cook SJ. DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5. Cell Signal 2008; 20:836-843.
14. LeBlond CP, Messier B, Kopriwa B. Thymidine-H3 as a tool for the investigation of the renewal of cell populations. Lab Invest 1959; 8:296-306.
15. Cotsarelis G, Cheng SZ, Dong G, Sun TT, Lavker RM. Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 1989; 57:201-209.
16. Budak MT, Alpdogan OS, Zhou M, Lavker RM, Akinci MA, Wolosin JM. Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells. J Cell Sci 2005; 118:1715-1724.
17. Akinci MA, Turner H, Taveras M, Barash A, Wang Z, Reinach P, Wolosin JM. Molecular profiling of conjunctival epithelial side-population stem cells: atypical cell surface markers and sources of a slow-cycling phenotype. Invest Ophthalmol Vis Sci 2009; 50:4162-4172.
18. Akinci MA, Turner H, Taveras M, Wolosin JM. Differential gene expression in the pig limbal side population: implications for stem cell cycling, replication, and survival. Invest Ophthalmol Vis Sci 2009; 50:5630-5638.
19. Wolosin JM, Xiong X, Schütte M, Stegman Z, Tieng A. Stem cells and differentiation stages in the limbo-corneal epithelium. Prog Retin Eye Res 2000; 19:223-255.
20. Turner HC, Budak MT, Akinci MA, Wolosin JM. Comparative analysis of human conjunctival and corneal epithelial gene expression with oligonucleotide microarrays. Invest Ophthalmol Vis Sci 2007; 48:2050-2061.
21. Vellonen KS, Mannermaa E, Turner H, Häkli M, Wolosin JM, Tervo T, Honkakoski P, Urtti A. Effluxing ABC transporters in human corneal epithelium. J Pharm Sci 2010; 99:1087-1098.
22. Yamasaki K, Kawasaki S, Young RD, Fukuoka H, Tanioka H, Nakatsukasa M, Quantock AJ, Kinoshita S. Genomic aberrations and cellular heterogeneity in SV40-immortalized human corneal epithelial cells. Invest Ophthalmol Vis Sci 2009; 50:604-613.
23. Wang Z, Yang H, Zhang F, Pan Z, Capó-Aponte J, Reinach PS. Dependence of EGF-induced increases in corneal epithelial proliferation and migration on GSK-3 inactivation. Invest Ophthalmol Vis Sci 2009; 50:4828-4835.
24. Boyce ST, Ham RG. Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture. J Invest Dermatol 1983; 81:33s-40s.
25. Umemoto T, Yamato M, Nishida K, Yang J, Tano Y, Okano T. Limbal epithelial side-population cells have stem cell-like properties, including quiescent state. Stem Cells 2006; 24:86-94.
26. Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 1997; 3:1337-1345.
27. Shen YH, Godlewski J, Zhu J, Sathyanarayana P, Leaner V, Birrer MJ, Rana A, Tzivion G. Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors. J Biol Chem 2003; 278:26715-26721.
28. Zhang H, Shi X, Hampong M, Blanis L. Pelech, S. Stressinduced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase. J Biol Chem 2001; 276:6905-6908.
29. Verma G, Datta M. IL-1beta induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa-2 cells. Apoptosis 2010; 15:864-876.
30. Maier JV, Brema S, Tuckermann J, Herzer U, Klein M, Stassen M, Moorthy A, Cato AC. Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids. Mol Endocrinol 2007; 21:2663-2671.
31. Chen Z, Tong L, Li Z, Yoon KC, Qi H, Farley W, Li DQ, Pflugfelder SC. Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Invest Ophthalmol Vis Sci 2008; 49:539-549.