Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1

Molecular and Cellular Biology

Volumn 34, Issue 17, 2014, Pages 3214-3228

  Fritsch, Jürgen ^a   Stephan, Mario ^a   Tchikov, Vladimir ^a   Winoto Morbach, Supandi ^a   Gubkina, Svetlana ^a   Kabelitz, Dieter ^a   Schütze, Stefan ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 8; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN; RIP1 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UBIQUITIN LIGASE RNF8; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; AGFG1 PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; DNA BINDING PROTEIN; FADD PROTEIN, HUMAN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; NUCLEOPORIN; RNA BINDING PROTEIN; RNF8 PROTEIN, HUMAN; RNF8 PROTEIN, MOUSE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UBC13 PROTEIN, MOUSE; UBIQUITIN CONJUGATING ENZYME;

APOPTOSIS; ARTICLE; CELL DEATH; CELL FATE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM; UBIQUITINATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; DEFICIENCY; ENDOCYTOSIS; GENETICS; HELA CELL LINE; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION; U937 CELL LINE;

ANIMALS; APOPTOSIS; CASPASE 8; CELL LINE; CELL SURVIVAL; DNA-BINDING PROTEINS; ENDOCYTOSIS; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HELA CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; NUCLEAR PORE COMPLEX PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84925581119     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00048-14     Document Type: Article

References (49)

1. Guicciardi ME, Gores GJ. 2009. Life and death by death receptors. FASEB J. 23:1625-1637. http://dx.doi.org/10.1096/fj.08-111005.
2. Micheau O, Tschopp J. 2003. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181-190. http://dx.doi.org/10.1016/S0092-8674(03)00521-X.
3. Schneider-Brachert W, Tchikov V, Neumeyer J, Jakob M, Winoto-Morbach S, Held-Feindt J, Heinrich M, Merkel O, Ehrenschwender M, Adam D, Mentlein R, Kabelitz D, Schütze S. 2004. Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21:415-428. http://dx.doi.org/10.1016/j.immuni.2004.08.017.
4. Schneider-Brachert W, Tchikov V, Merkel O, Jakob M, Hallas C, Kruse ML, Groitl P, Lehn A, Hildt E, Held-Feindt J, Dobner T, Kabelitz D, Krönke M, Schütze S. 2006. Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism. J. Clin. Invest. 116:2901-2913. http://dx.doi.org/10.1172/JCI23771.
5. Edelmann B, Bertsch U, Tchikov V, Winoto-Morbach S, Perrotta C, Jakob M, Adam-Klages S, Kabelitz D, Schütze S. 2011. Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes. EMBO J. 30:379-394. http://dx.doi.org/10.1038/emboj.2010.326.
6. Heinrich M, Wickel M, Schneider-Brachert W, Sandberg C, Gahr J, Schwandner R, Weber T, Saftig P, Peters C, Brunner J, Krönke M, Schütze S. 1999. Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J. 18:5252-5263.
7. Heinrich M, Neumeyer J, Jakob M, Hallas C, Tchikov V, Winoto-Morbach S, Wickel M, Schneider-Brachert W, Trauzold A, Hethke A, Schütze S. 2004. Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and-3 activation. Cell Death Differ. 11:550-563 http://dx.doi.org/10.1038/sj.cdd.4401382.
8. Schütze S, Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse ML, Heinrich M, Wickel M, Krönke M. 1999. Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 TNF receptor death domain signaling. J. Biol. Chem. 274:10203-10212. http://dx.doi.org/10.1074/jbc.274.15.10203.
9. Schütze S, Tchikov V, Schneider-Brachert W. 2008. Regulation of TNFR1 and CD95 signaling by receptor compartmentalization. Nat. Rev. Mol. Cell Biol. 9:655-662. http://dx.doi.org/10.1038/nrm2430.
10. Schütze S, Schneider-Brachert W. 2009. Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling. Results Probl. Cell Differ. 49:63-85. http://dx.doi.org/10.1007/400_2008_23.
11. Wertz IE, Dixit VM. 2010. Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ. 17:14-24. http://dx.doi.org/10.1038/cdd.2009.168.
12. Liu S, Chen Z. 2011. Expanding role of ubiquitination in NF-κB signaling. Cell Res. 21:6-21. http://dx.doi.org/10.1038/cr.2010.170.
13. Vucic D, Dixit VM, Wertz IE. 2011. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nat. Rev. Mol. Cell Biol. 12:439-452. http://dx.doi.org/10.1038/nrm3143.
14. Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Conze D, El-Deiry WS, Schütze S, Srinivasula SM. 2008. CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-κB activation. Curr. Biol. 18:641-649. http://dx.doi.org/10.1016/j.cub.2008.04.017.
15. Liao W, Fujita K, Tchikov V, Yang W, Gunsor M, Garfield S, Goldsmith P, El-Deiry WS, Schutze S, Srinoivasula SM. 2009. Response: CARP1 regulates induction of NF-κBby TNFα. Curr. Biol. 19:R17-R19. http://dx.doi.org/10.1016/j.cub.2008.11.041.
16. Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM. 2008. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 134:668-678. http://dx.doi.org/10.1016/j.cell.2008.07.039.
17. Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholson TP, Sheppard PW, Häcker H, Karin M, Vignali DA. 2008. Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc. Natl. Acad. Sci. U. S. A. 105:20197-20202. http://dx.doi.org/10.1073/pnas.0810461105.
18. Tchikov V, Schütze S. 2008. Immunomagnetic isolation of tumor necrosis factor receptosomes. Methods Enzymol. 442:101-123. http://dx.doi.org/10.1016/S0076-6879(08)01405-5.
19. Schütze S, Tchikov V, Kabelitz D, Krönke M. March 2003. German patent DE 101 44 29.
20. Pandey KN. 2009. Functional roles of short sequence motifs in the endocytosis of membrane receptors. Front. Biosci. (Landmark Ed.) 14:5339-5360 http://dx.doi.org/10.2741/3599.
21. Stanger BZ, Leder P, Lee TH, Kim E, Seed B. 1995. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81:513-523. http://dx.doi.org/10.1016/0092-8674(95)90072-1.
22. Hsu H, Shu HB, Pan MG, Goeddel DV. 1996. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84:299-308. http://dx.doi.org/10.1016/S0092-8674(00)80984-8.
23. Zheng L, Bidere N, Staudt D, Cubre A, Orenstein J, Chan FK, Lenardo M. 2006. Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol. Cell. Biol. 26:3505-3513. http://dx.doi.org/10.1128/MCB.26.9.3505-3513.2006.
24. Jin Z, El Deiry WS. 2006. Distinct signaling pathways in TRAIL-versus tumor necrosis factor-induced apoptosis. Mol. Cell. Biol. 26:8136-8148. http://dx.doi.org/10.1128/MCB.00257-06.
25. Ali M, Fritsch J, Zigdon H, Pewzner-Jung Y, Schütze S, Futerman A. 2013 Altering acyl chain composition of sphingolipids prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization. Cell Death Dis. 4:e929. http://dx.doi.org/10.1038/cddis.2013.451.
26. Piper RC, Lehner PJ. 2011. Endosomal transport via ubiquitination. Trends Cell Biol. 21:647-655. http://dx.doi.org/10.1016/j.tcb.2011.08.007.
27. Shenoy SK. 2007. Seven-transmembrane receptors and ubiquitination. Circ. Res. 100:1142-1154. http://dx.doi.org/10.1161/01.RES.0000261939.88744.5a.
28. Cadigan KM. 2010. Receptor endocytosis: Frizzled joins the ubiquitin club. EMBO J. 29:2099-2100. http://dx.doi.org/10.1038/emboj.2010.132.
29. Lei JT, Mazumdar T, Martinez-Moczygemba M. 2011. Three lysine residues in the common beta chain of the IL-5 receptor are required for JAKdependent receptor ubiquitination, endocytosis and signaling. J. Biol. Chem. 286:40091-44103. http://dx.doi.org/10.1074/jbc.M111.273482.
30. Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C. 2003. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation. Immunity 18:655-664. http://dx.doi.org/10.1016/S1074-7613(03)00092-X.
31. Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. 2010. Identification, analysis, and prediction of protein ubiquitination sites. Proteins 78:365-380. http://dx.doi.org/10.1002/prot.22555.
32. Petroski MD, Deshaies RJ. 2003. Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. Mol. Cell 11:1435-1444. http://dx.doi.org/10.1016/S1097-2765(03)00221-1.
33. Amir RE, Haecker H, Karin M, Ciechanover A. 2004. Mechanism of processing of the NF-κ B2 p100 precursor: identification of the specific polyubiquitin chain anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene 23:2540-2547. http://dx.doi.org/10.1038/sj.onc.1207366.
34. Fung TK, Yam CH, Poon RY. 2005. The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites. Cell Cycle 4:1411-1420. http://dx.doi.org/10.4161/cc.4.10.2046.
35. Chan WM, Mak MC, Fung TK, Lau A, Siu WY, Poon RY. 2006. Ubiquitination of p53 at multiple sites in the DNA-binding domain. Mol. Cancer Res. 4:15-25. http://dx.doi.org/10.1158/1541-7786.MCR-05-0097.
36. Ju D, Xie Y. 2006. Identification of the preferential ubiquitination site and ubiquitin-dependent degradation signal of Rpn4. J. Biol. Chem. 281: 10657-10662. http://dx.doi.org/10.1074/jbc.M513790200.
37. Hagai T, Tóth-Petróczy ÁA, Azia A, Levy Y. 2012. The origins and evolution of ubiquitination sites. Mol. Biosyst. 8:1865-7187. http://dx.doi.org/10.1039/c2mb25052g.
38. Hurley JH, Lee S, Prag G. 2006. Ubiquitin-binding domains. Biochem. J. 399:361-372. http://dx.doi.org/10.1042/BJ20061138.
39. Tran H, Hamada F, Schwarz-Romond T, Bienz M, Trabid A. 2008. New positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 22:528-542. http://dx.doi.org/10.1101/gad.463208.
40. Sato Y, Yoshikawa A, Yamashita M, Yamagata A, Fukai S. 2009. Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3. EMBO J. 28:3903-3909. http://dx.doi.org/10.1038/emboj.2009.345.
41. Katzmann DJ, Odorizzi G, Emr SD. 2002. Receptor downregulation and multivesicular body sorting. Nat. Rev. Mol. Cell Biol. 3:893-905. http://dx.doi.org/10.1038/nrm973.
42. Shields SB, Oestreich AJ, Winistorfer S, Nguyen D, Payne JA, Katzmann DJ, Piper R. 2009. ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting. J. Cell Biol. 185:213-224. http://dx.doi.org/10.1083/jcb.200811130.
43. Hurley JH, Hanson PI. 2010. Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat. Rev. Mol. Cell Biol. 11:556-566 http://dx.doi.org/10.1038/nrm2937.
44. Mahul-Mellier AL, Strappazzon F, Petiot A, Chatellard-Causse C, Torch S, Blot B, Freeman K, Kuhn L, Garin J, Verna JM, Fraboulet S, Sadoul R. 2008. Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. J. Biol. Chem. 283:34954-34965. http://dx.doi.org/10.1074/jbc.M803140200.
45. Mahul-Mellier AL, Hemming FJ, Blot B, Fraboulet S, Sadoul R. 2006. Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo. J. Neurosci. 26:542-549. http://dx.doi.org/10.1523/JNEUROSCI.3069-05.2006.
46. Grabbe C, Husnjak K, Dikic I. 2011. The spatial and temporal organization of ubiquitin networks. Nat. Rev. Mol. Cell Biol. 12:295-307. http://dx.doi.org/10.1038/nrm3099.
47. Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. 2007. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131:901-914. http://dx.doi.org/10.1016/j.cell.2007.09.041.
48. Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J. 2009. RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat. Cell Biol. 11:592-603. http://dx.doi.org/10.1038/ncb1865.
49. Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S. 2011. The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat. Struct. Mol. Biol. 18:1400-1407. http://dx.doi.org/10.1038/nsmb.2172.