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Volumn 6, Issue 2, 2015, Pages 127-138

Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells

Author keywords

apoptosis; casein kinase I ; FoxO3; hepatocarcinoma; TGF

Indexed keywords

BETA ACTIN; BIM PROTEIN; CASEIN KINASE IEPSILON; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOCHROME C; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLSERINE; PHOSPHORUS 32; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; SOMATOMEDIN C; THREONINE; THREONINE 32; TRANSCRIPTION FACTOR FKHRL1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; MEMBRANE PROTEIN; ONCOPROTEIN;

EID: 84925541100     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-014-0121-5     Document Type: Article
Times cited : (23)

References (46)
  • 1
    • 0029984594 scopus 로고    scopus 로고
    • Inhibition of cell growth by transforming growth factor β1 is associated with p53-independent induction of p21 in gastric carcinoma cells
    • COI: 1:CAS:528:DyaK28XisFOht7k%3D, PID: 8641969
    • Akagi M, Yasui W, Akama Y, Yokozaki H, Tahara H, Haruma K, Kajiyama G, Tahara E (1996) Inhibition of cell growth by transforming growth factor β1 is associated with p53-independent induction of p21 in gastric carcinoma cells. Jpn J Cancer Res 87:377–384
    • (1996) Jpn J Cancer Res , vol.87 , pp. 377-384
    • Akagi, M.1    Yasui, W.2    Akama, Y.3    Yokozaki, H.4    Tahara, H.5    Haruma, K.6    Kajiyama, G.7    Tahara, E.8
  • 2
    • 0035019007 scopus 로고    scopus 로고
    • Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    • COI: 1:CAS:528:DC%2BD3MXjs1Cgu7g%3D, PID: 11353388
    • Biggs WH III, Cavenee WK, Arden KC (2001) Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome 12:416–425
    • (2001) Mamm Genome , vol.12 , pp. 416-425
    • Biggs, W.H.1    Cavenee, W.K.2    Arden, K.C.3
  • 4
    • 0035496921 scopus 로고    scopus 로고
    • Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma
    • COI: 1:CAS:528:DC%2BD3MXnsVChtrY%3D, PID: 11568006
    • Chen Q, Gong B, Mahmoud-Ahmed AS, Zhou A, Hsi ED, Hussein M, Almasan A (2001) Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma. Blood 98:2183–2192
    • (2001) Blood , vol.98 , pp. 2183-2192
    • Chen, Q.1    Gong, B.2    Mahmoud-Ahmed, A.S.3    Zhou, A.4    Hsi, E.D.5    Hussein, M.6    Almasan, A.7
  • 5
    • 2342471301 scopus 로고    scopus 로고
    • Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β induced apoptosis
    • COI: 1:CAS:528:DC%2BD2cXis1Gltb8%3D, PID: 15104092
    • Conery AR, Cao Y, Thompson EA, Townsend CM Jr, Ko TC, Luo K (2004) Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β induced apoptosis. Nat Cell Biol 6:366–372
    • (2004) Nat Cell Biol , vol.6 , pp. 366-372
    • Conery, A.R.1    Cao, Y.2    Thompson, E.A.3    Townsend, C.M.4    Ko, T.C.5    Luo, K.6
  • 6
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • COI: 1:CAS:528:DC%2BD3sXnvV2hs7c%3D, PID: 14534577
    • Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425:577–584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 7
    • 0032540280 scopus 로고    scopus 로고
    • RhoB is stabilized by transforming growth factor β and antagonizes transcriptional activation
    • COI: 1:CAS:528:DyaK1cXivVOrs74%3D, PID: 9545335
    • Engel ME, Datta PK, Moses HL (1998) RhoB is stabilized by transforming growth factor β and antagonizes transcriptional activation. J Biol Chem 273:9921–9926
    • (1998) J Biol Chem , vol.273 , pp. 9921-9926
    • Engel, M.E.1    Datta, P.K.2    Moses, H.L.3
  • 9
    • 0029036113 scopus 로고
    • Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family
    • COI: 1:CAS:528:DyaK2MXmsFKqs74%3D, PID: 7797465
    • Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (1995) Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. J Biol Chem 270:14875–14883
    • (1995) J Biol Chem , vol.270 , pp. 14875-14883
    • Fish, K.J.1    Cegielska, A.2    Getman, M.E.3    Landes, G.M.4    Virshup, D.M.5
  • 10
    • 0027418069 scopus 로고
    • Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis
    • COI: 1:CAS:528:DyaK3sXksVCit7k%3D, PID: 8454611
    • Graves PR, Haas DW, Hagedorn CH, Paoli-Roach AA, Roach PJ (1993) Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis. J Biol Chem 268:6394–6401
    • (1993) J Biol Chem , vol.268 , pp. 6394-6401
    • Graves, P.R.1    Haas, D.W.2    Hagedorn, C.H.3    Paoli-Roach, A.A.4    Roach, P.J.5
  • 11
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • COI: 1:CAS:528:DyaK1cXlvVegsLo%3D, PID: 9721092
    • Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309–1312
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 12
    • 84861359957 scopus 로고    scopus 로고
    • FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3
    • COI: 1:CAS:528:DC%2BC38XnsVWjsb0%3D, PID: 22349704
    • Hagenbuchner J, Kuznetsov A, Hermann M, Hausott B, Obexer P, Ausserlechner MJ (2012) FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3. J Cell Sci 125:1191–1203
    • (2012) J Cell Sci , vol.125 , pp. 1191-1203
    • Hagenbuchner, J.1    Kuznetsov, A.2    Hermann, M.3    Hausott, B.4    Obexer, P.5    Ausserlechner, M.J.6
  • 13
    • 0032868499 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells
    • COI: 1:CAS:528:DyaK1MXmtFOrt7w%3D, PID: 10479654
    • Higaki M, Shimokado K (1999) Phosphatidylinositol 3-kinase is required for growth factor-induced amino acid uptake by vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 19:2127–2132
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 2127-2132
    • Higaki, M.1    Shimokado, K.2
  • 14
    • 0032191407 scopus 로고    scopus 로고
    • Synergistic cooperation of TFE3 and smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene
    • COI: 1:CAS:528:DyaK1cXmslegtrk%3D, PID: 9765209
    • Hua X, Liu X, Ansari DO, Lodish HF (1998) Synergistic cooperation of TFE3 and smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev 12:3084–3095
    • (1998) Genes Dev , vol.12 , pp. 3084-3095
    • Hua, X.1    Liu, X.2    Ansari, D.O.3    Lodish, H.F.4
  • 15
    • 13944271654 scopus 로고    scopus 로고
    • Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation
    • COI: 1:CAS:528:DC%2BD3sXntVCjtbw%3D, PID: 12888923
    • Huynh H, Nguyen TT, Chan E, Tran E (2003) Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation. Int J Oncol 23:821–829
    • (2003) Int J Oncol , vol.23 , pp. 821-829
    • Huynh, H.1    Nguyen, T.T.2    Chan, E.3    Tran, E.4
  • 17
    • 33845262863 scopus 로고    scopus 로고
    • Role of the Akt/FoxO3a pathway in TGF-β1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease
    • COI: 1:CAS:528:DC%2BD28XhtlGiu7nI, PID: 17082237
    • Kato M, Yuan H, Xu ZG, Lanting L, Li SL, Wang M, Hu MC, Reddy MA, Natarajan R (2006) Role of the Akt/FoxO3a pathway in TGF-β1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease. J Am Soc Nephrol 17:3325–3335
    • (2006) J Am Soc Nephrol , vol.17 , pp. 3325-3335
    • Kato, M.1    Yuan, H.2    Xu, Z.G.3    Lanting, L.4    Li, S.L.5    Wang, M.6    Hu, M.C.7    Reddy, M.A.8    Natarajan, R.9
  • 18
    • 13844294211 scopus 로고    scopus 로고
    • The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
    • COI: 1:CAS:528:DC%2BD2MXhslWltb4%3D, PID: 15722192
    • Knippschild U, Gocht A, Wolff S, Huber N, Lohler J, Stoter M (2005) The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal 17:675–689
    • (2005) Cell Signal , vol.17 , pp. 675-689
    • Knippschild, U.1    Gocht, A.2    Wolff, S.3    Huber, N.4    Lohler, J.5    Stoter, M.6
  • 19
    • 0032759047 scopus 로고    scopus 로고
    • Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling
    • COI: 1:CAS:528:DyaK1MXns1SqurY%3D
    • Kops GJ, Burgering BM (1999) Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J Mol Med (Berl) 77:656–665
    • (1999) J Mol Med (Berl) , vol.77 , pp. 656-665
    • Kops, G.J.1    Burgering, B.M.2
  • 21
    • 0029904671 scopus 로고    scopus 로고
    • Serine/threonine kinase receptors: mediators of transforming growth factor β family signals
    • COI: 1:CAS:528:DyaK28XntlSns7o%3D, PID: 8909794
    • Massague J, Weis-Garcia F (1996) Serine/threonine kinase receptors: mediators of transforming growth factor β family signals. Cancer Surv 27:41–64
    • (1996) Cancer Surv , vol.27 , pp. 41-64
    • Massague, J.1    Weis-Garcia, F.2
  • 22
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • COI: 1:CAS:528:DC%2BD2MXhtlWqsrnI, PID: 16322555
    • Massague J, Seoane J, Wotton D (2005) Smad transcription factors. Genes Dev 19:2783–2810
    • (2005) Genes Dev , vol.19 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 23
    • 0033788062 scopus 로고    scopus 로고
    • TGF-beta/SMAD signaling and its involvement in tumor progression
    • COI: 1:CAS:528:DC%2BD3cXnt1Kqs7w%3D, PID: 11041237
    • Miyazono K (2000) TGF-beta/SMAD signaling and its involvement in tumor progression. Biol Pharm Bull 23:1125–1130
    • (2000) Biol Pharm Bull , vol.23 , pp. 1125-1130
    • Miyazono, K.1
  • 24
    • 76249087423 scopus 로고    scopus 로고
    • TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    • COI: 1:CAS:528:DC%2BC3cXhsVygtL4%3D, PID: 20130650
    • Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, Nakao S, Motoyama N, Hirao A (2010) TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 463:676–680
    • (2010) Nature , vol.463 , pp. 676-680
    • Naka, K.1    Hoshii, T.2    Muraguchi, T.3    Tadokoro, Y.4    Ooshio, T.5    Kondo, Y.6    Nakao, S.7    Motoyama, N.8    Hirao, A.9
  • 25
    • 0030567912 scopus 로고    scopus 로고
    • Role for Bcl-xL in the regulation of apoptosis by EGF and TGF-β in c-myc overexpressing mammary epithelial cells
    • COI: 1:CAS:528:DyaK28XmtVKlsbk%3D, PID: 8858133
    • Nass SJ, Li M, Amundadottir LT, Furth PA, Dickson RB (1996) Role for Bcl-xL in the regulation of apoptosis by EGF and TGF-β in c-myc overexpressing mammary epithelial cells. Biochem Biophys Res Commun 227:248–256
    • (1996) Biochem Biophys Res Commun , vol.227 , pp. 248-256
    • Nass, S.J.1    Li, M.2    Amundadottir, L.T.3    Furth, P.A.4    Dickson, R.B.5
  • 26
    • 38049148308 scopus 로고    scopus 로고
    • FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
    • COI: 1:CAS:528:DC%2BD1cXjsleltA%3D%3D, PID: 18077353
    • Ni YG, Wang N, Cao DJ, Sachan N, Morris DJ, Gerard RD, Kuro O, Rothermel BA, Hill JA (2007) FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A 104:20517–20522
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20517-20522
    • Ni, Y.G.1    Wang, N.2    Cao, D.J.3    Sachan, N.4    Morris, D.J.5    Gerard, R.D.6    Kuro, O.7    Rothermel, B.A.8    Hill, J.A.9
  • 27
    • 84881239289 scopus 로고    scopus 로고
    • FOG2 protein down-regulation by transforming growth factor-β1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy
    • COI: 1:CAS:528:DC%2BC3sXht1Whtr%2FN, PID: 23788640
    • Park JT, Kato M, Yuan H, Castro N, Lanting L, Wang M, Natarajan R (2013) FOG2 protein down-regulation by transforming growth factor-β1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy. J Biol Chem 288:22469–22480
    • (2013) J Biol Chem , vol.288 , pp. 22469-22480
    • Park, J.T.1    Kato, M.2    Yuan, H.3    Castro, N.4    Lanting, L.5    Wang, M.6    Natarajan, R.7
  • 28
    • 1442286386 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β and matrix metalloproteinases by estrogen and prolactin in breast cancer cells
    • COI: 1:CAS:528:DC%2BD2cXhs12lsr4%3D, PID: 15019161
    • Philips N, McFadden K (2004) Inhibition of transforming growth factor-β and matrix metalloproteinases by estrogen and prolactin in breast cancer cells. Cancer Lett 206:63–68
    • (2004) Cancer Lett , vol.206 , pp. 63-68
    • Philips, N.1    McFadden, K.2
  • 29
    • 79251564039 scopus 로고    scopus 로고
    • Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells
    • COI: 1:CAS:528:DC%2BC3MXisFyis74%3D, PID: 21109589
    • Qi W, Weber CR, Wasland K, Roy H, Wali R, Joshi S, Savkovic SD (2011a) Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. Am J Physiol Gastrointest Liver Physiol 300:G264–G272
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G264-G272
    • Qi, W.1    Weber, C.R.2    Wasland, K.3    Roy, H.4    Wali, R.5    Joshi, S.6    Savkovic, S.D.7
  • 30
    • 79957844724 scopus 로고    scopus 로고
    • Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity
    • COI: 1:CAS:528:DC%2BC3MXnsVGju7g%3D, PID: 21639915
    • Qi W, Weber CR, Wasland K, Savkovic SD (2011b) Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. BMC Cancer 11:219
    • (2011) BMC Cancer , vol.11 , pp. 219
    • Qi, W.1    Weber, C.R.2    Wasland, K.3    Savkovic, S.D.4
  • 31
    • 33847067437 scopus 로고    scopus 로고
    • Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis
    • COI: 1:CAS:528:DC%2BD2sXhslWhtL4%3D, PID: 16909112
    • Ramjaun AR, Tomlinson S, Eddaoudi A, Downward J (2007) Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. Oncogene 26:970–981
    • (2007) Oncogene , vol.26 , pp. 970-981
    • Ramjaun, A.R.1    Tomlinson, S.2    Eddaoudi, A.3    Downward, J.4
  • 32
    • 2342647439 scopus 로고    scopus 로고
    • PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3
    • COI: 1:CAS:528:DC%2BD2cXis1GltLY%3D, PID: 15048128
    • Remy I, Montmarquette A, Michnick SW (2004) PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3. Nat Cell Biol 6:358–365
    • (2004) Nat Cell Biol , vol.6 , pp. 358-365
    • Remy, I.1    Montmarquette, A.2    Michnick, S.W.3
  • 33
    • 58149474378 scopus 로고    scopus 로고
    • Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-β pathway—implication of C-Krox and Sp1
    • COI: 1:CAS:528:DC%2BD1MXhvVGmsbc%3D, PID: 18298657
    • Renard E, Chadjichristos C, Kypriotou M, Beauchef G, Bordat P, Dompmartin A, Widom RL, Boumediene K, Pujol JP, Galera P (2008) Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-β pathway—implication of C-Krox and Sp1. J Cell Mol Med 12:2836–2847
    • (2008) J Cell Mol Med , vol.12 , pp. 2836-2847
    • Renard, E.1    Chadjichristos, C.2    Kypriotou, M.3    Beauchef, G.4    Bordat, P.5    Dompmartin, A.6    Widom, R.L.7    Boumediene, K.8    Pujol, J.P.9    Galera, P.10
  • 35
    • 84867817888 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-β 1
    • COI: 1:CAS:528:DC%2BC38XhsFequ7nJ, PID: 22942286
    • Runyan CE, Liu Z, Schnaper HW (2012) Phosphatidylinositol 3-kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming growth factor-β 1. J Biol Chem 287:35815–35824
    • (2012) J Biol Chem , vol.287 , pp. 35815-35824
    • Runyan, C.E.1    Liu, Z.2    Schnaper, H.W.3
  • 36
    • 0037126303 scopus 로고    scopus 로고
    • Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    • COI: 1:CAS:528:DC%2BD38XnvVyrt7g%3D, PID: 12384701
    • Seoane J, Le HV, Massague J (2002) Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419:729–734
    • (2002) Nature , vol.419 , pp. 729-734
    • Seoane, J.1    Le, H.V.2    Massague, J.3
  • 37
    • 30044435438 scopus 로고    scopus 로고
    • Tid1 is a Smad-binding protein that can modulate Smad7 activity in developing embryos
    • COI: 1:CAS:528:DC%2BD28XivVKksg%3D%3D, PID: 16156721
    • Torregroza I, Evans T (2006) Tid1 is a Smad-binding protein that can modulate Smad7 activity in developing embryos. Biochem J 393:311–320
    • (2006) Biochem J , vol.393 , pp. 311-320
    • Torregroza, I.1    Evans, T.2
  • 38
    • 38649103187 scopus 로고    scopus 로고
    • Phosphatases at the heart of FoxO metabolic control
    • COI: 1:CAS:528:DC%2BD1cXitVWht78%3D, PID: 18249169
    • Tremblay ML, Giguere V (2008) Phosphatases at the heart of FoxO metabolic control. Cell Metab 7:101–103
    • (2008) Cell Metab , vol.7 , pp. 101-103
    • Tremblay, M.L.1    Giguere, V.2
  • 39
    • 0026039891 scopus 로고
    • Casein kinase I and II–multipotential serine protein kinases: structure, function, and regulation
    • COI: 1:STN:280:DyaK3M7ksVyqug%3D%3D, PID: 1997039
    • Tuazon PT, Traugh JA (1991) Casein kinase I and II–multipotential serine protein kinases: structure, function, and regulation. Adv Second Messenger Phosphoprotein Res 23:123–164
    • (1991) Adv Second Messenger Phosphoprotein Res , vol.23 , pp. 123-164
    • Tuazon, P.T.1    Traugh, J.A.2
  • 40
    • 0036902409 scopus 로고    scopus 로고
    • Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP
    • COI: 1:CAS:528:DC%2BD38XptFKmt7Y%3D, PID: 12447389
    • Valderrama-Carvajal H, Cocolakis E, Lacerte A, Lee EH, Krystal G, Ali S, Lebrun JJ (2002) Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP. Nat Cell Biol 4:963–969
    • (2002) Nat Cell Biol , vol.4 , pp. 963-969
    • Valderrama-Carvajal, H.1    Cocolakis, E.2    Lacerte, A.3    Lee, E.H.4    Krystal, G.5    Ali, S.6    Lebrun, J.J.7
  • 41
    • 0034028329 scopus 로고    scopus 로고
    • Ski and SnoN: antagonistic proteins of TGF-β signaling
    • COI: 1:STN:280:DC%2BD3c7ntFWitA%3D%3D, PID: 10705283
    • Vignais ML (2000) Ski and SnoN: antagonistic proteins of TGF-β signaling. Bull Cancer 87:135–137
    • (2000) Bull Cancer , vol.87 , pp. 135-137
    • Vignais, M.L.1
  • 42
    • 25444442080 scopus 로고    scopus 로고
    • Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins
    • COI: 1:CAS:528:DC%2BD28XhslCrurs%3D, PID: 15917664
    • Vogt PK, Jiang H, Aoki M (2005) Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle 4:908–913
    • (2005) Cell Cycle , vol.4 , pp. 908-913
    • Vogt, P.K.1    Jiang, H.2    Aoki, M.3
  • 43
    • 3142748521 scopus 로고    scopus 로고
    • Casein kinase Iepsilon plays a functional role in the transforming growth factor-β signaling pathway
    • COI: 1:CAS:528:DC%2BD2cXlsVCmsL8%3D, PID: 15133026
    • Waddell DS, Liberati NT, Guo X, Frederick JP, Wang XF (2004) Casein kinase Iepsilon plays a functional role in the transforming growth factor-β signaling pathway. J Biol Chem 279:29236–29246
    • (2004) J Biol Chem , vol.279 , pp. 29236-29246
    • Waddell, D.S.1    Liberati, N.T.2    Guo, X.3    Frederick, J.P.4    Wang, X.F.5
  • 44
    • 67749127709 scopus 로고    scopus 로고
    • Runx1 is a co-activator with FOXO3 to mediate transforming growth factor β (TGF-β)-induced Bim transcription in hepatic cells
    • COI: 1:CAS:528:DC%2BD1MXos1ensLo%3D, PID: 19494111
    • Wildey GM, Howe PH (2009) Runx1 is a co-activator with FOXO3 to mediate transforming growth factor β (TGF-β)-induced Bim transcription in hepatic cells. J Biol Chem 284:20227–20239
    • (2009) J Biol Chem , vol.284 , pp. 20227-20239
    • Wildey, G.M.1    Howe, P.H.2
  • 45
    • 0034680863 scopus 로고    scopus 로고
    • Critical role of Smads and AP-1 complex in transforming growth factor-β-dependent apoptosis
    • COI: 1:CAS:528:DC%2BD3cXosVSrs7o%3D, PID: 10942775
    • Yamamura Y, Hua X, Bergelson S, Lodish HF (2000) Critical role of Smads and AP-1 complex in transforming growth factor-β-dependent apoptosis. J Biol Chem 275:36295–36302
    • (2000) J Biol Chem , vol.275 , pp. 36295-36302
    • Yamamura, Y.1    Hua, X.2    Bergelson, S.3    Lodish, H.F.4
  • 46
    • 43149103684 scopus 로고    scopus 로고
    • PP2A regulates the pro-apoptotic activity of FOXO1
    • COI: 1:CAS:528:DC%2BD1cXjt1emur8%3D, PID: 18211894
    • Yan L, Lavin VA, Moser LR, Cui Q, Kanies C, Yang E (2008) PP2A regulates the pro-apoptotic activity of FOXO1. J Biol Chem 283:7411–7420
    • (2008) J Biol Chem , vol.283 , pp. 7411-7420
    • Yan, L.1    Lavin, V.A.2    Moser, L.R.3    Cui, Q.4    Kanies, C.5    Yang, E.6


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