Ski and SnoN: Antagonistic proteins of TGFβ signaling;Ski et SnoN: Des oncoproteines antagonistes de la signalisation TGFβ

Bulletin du Cancer

Volumn 87, Issue 2, 2000, Pages 135-137

  Vignais, Marie Luce ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

Ski; SnoN

Indexed keywords

CANCER GROWTH FACTOR; HISTONE DEACETYLASE; PROTEIN DERIVATIVE; DNA; DNA BINDING PROTEIN; ONCOPROTEIN; SMAD3 PROTEIN; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

CARCINOGENESIS; FEEDBACK SYSTEM; GENE EXPRESSION; GENE TARGETING; GENETIC ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; REVIEW; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; GENETIC TRANSCRIPTION; METABOLISM; PHYSIOLOGY;

DNA; DNA-BINDING PROTEINS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034028329     PISSN: 00074551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (12)

1. 1. Nomura N, Sasamoto S, Ishii S, Date T, Matsui M, Ishizaki R. Isolation of human cDNA clones of ski and the ski-related gene, sno. Nucleic Acids Res 1989 ; 17 : 5489-500.
2. 2. Li Y, Turck CM, Toumer JK, Stavnezer E. Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene. J Virol 1986 ; 57 : 1065-72.
3. 3. Nagase T, Nomura N, Ishii S. Complex formation between proteins encoded by the ski gene family. J Biol Chem 1993 ; 268 : 13710-6.
4. 4. Heyman HC, Stavnezer E. A carboxyl-terminal region of the ski oncoprotein mediates homodimerization as well as heterodimerization with the related protein SnoN. J Biol Chem 1994 ; 269 : 26996-7003.
5. 5. Nagase T, Mizuguchi G, Nomura N, Ishizaki R, Ueno Y, Ishii S. Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene product. Nucleic Acids Res 1990 ; 18 : 337-43.
6. 6. Nicol R, Stavnezer E. Transcriptional repression by v-Ski and c-Ski mediated by a specific DNA binding site. J Biol Chem 1998 ; 273 : 3588-97.
7. 7. Zawel L, Dai JL, Buckhaults P, Zhou S, Kinzler KW, Vogelstein B, Kern Se. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998 ; 1 : 611-7.
8. 8. Vignais ML. Signalisation cellulaire en réponse au TGFβ : le paradoxe d'une cytokine à la fois inhibitrice de la prolifération cellulaire et inductrice de métastases. Bull Cancer 1999 ; 11 : 903-10.
9. 9. Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K. Negative feedback regulation of TGE-beta signaling by the SnoN oncoprotein. Science 1999 ; 286 : 771-4.
10. 10. Luo K, Stroschein SL, Wang W, Chen D, Martens E, Zhou S, Zhou Q. The Ski oncoprotein interacts with the Smad proteins to repress TGF-beta signaling. Genes Deiv 1999 ; 13 : 2196-206.
11. 11. Sun Y, Liu X, Eaton EN, Lane WS, Lodish HF, Weinberg RA. Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. Mol Cell 1999 ; 4 : 499-509.
12. 12. Sun Y, Liu X, Ng-Eaton E, Lodish HF, Weinberg RA. SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling. Proc Natl Acad Sci USA 1999 ; 96 : 12442-7.