The bovine model for elucidating the role of γδ T cells in controlling infectious diseases of importance to cattle and humans

Molecular Immunology

Volumn 66, Issue 1, 2015, Pages 35-47

  Baldwin, Cynthia L ^a   Telfer, Janice C ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Cattle; Gamma delta T cell; Human; Leptospira; Mycobacteria

Indexed keywords

LEPTOSPIROSIS VACCINE; PATTERN RECOGNITION RECEPTOR; CD163 ANTIGEN; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; DMBT1 PROTEIN, BOS TAURUS; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN;

BACTERIUM; BCG VACCINATION; BOVINE; BOVINE MODEL; BOVINE TUBERCULOSIS; CELLULAR IMMUNITY; CYTOLOGY; GAMMA DELTA T LYMPHOCYTE; GENE; HUMAN; IMMUNE RESPONSE; INFECTION; MEMORY T LYMPHOCYTE; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; PROTOZOON; REVIEW; T LYMPHOCYTE ACTIVATION; WC1 GENE; ANIMAL; CATTLE DISEASE; IMMUNOLOGY; METABOLISM; MOUSE; PATHOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CATTLE; CATTLE DISEASES; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, CELL SURFACE; RECEPTORS, PATTERN RECOGNITION; T-LYMPHOCYTES;

EID: 84925533110     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2014.10.024     Document Type: Review

References (184)

1. Adams E.J., Chien Y.H., Garcia K.C. Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science 2005, 308:227-231.
2. Adams E.J., Strop P., Shin S., Chien Y.H., Garcia K.C. An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nat. Immunol. 2008, 9:777-784.
3. Akkaya M., Barclay A.N. How do pathogens drive the evolution of paired receptors?. Eur. J. Immunol. 2013, 43:303-313.
4. Baldwin C.L., Black S.J., Brown W.C., Conrad P.A., Goddeeris B.M., Kinuthia S.W., Lalor P.A., MacHugh N.D., Morrison W.I., Morzaria S.P., et al. Bovine T cells, B cells, and null cells are transformed by the protozoan parasite Theileria parva. Infect. Immun. 1988, 56:462-467.
5. Baldwin C.L., Hsu H., Chen C., Palmer M., McGill J., Waters W.R., Telfer J.C. The role of bovine gammadelta T cells and their WC1 co-receptor in response to bacterial pathogens and promoting vaccine efficacy: a model for cattle and humans. Vet. Immunol. Immunopathol. 2014, 159:144-155.
6. Baldwin C.L., Sathiyaseelan T., Rocchi M., McKeever D. Rapid changes occur in the percentage of circulating bovine WC1(+)gamma delta Th1 cells. Res. Vet. Sci. 2000, 69:175-180.
7. Baldwin C.L., Teale A.J., Naessens J.G., Goddeeris B.M., MacHugh N.D., Morrison W.I. Characterization of a subset of bovine T lymphocytes that express BoT4 by monoclonal antibodies and function: similarity to lymphocytes defined by human T4 and murine L3T4. J. Immunol. 1986, 136:4385-4391.
8. Band H., Hochstenbach F., McLean J., Hata S., Krangel M.S., Brenner M.B. Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit. Science 1987, 238:682-684.
9. Bank I., DePinho R.A., Brenner M.B., Cassimeris J., Alt F.W., Chess L. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature 1986, 322:179-181.
10. Barrett T., Rossiter P.B. Rinderpest: the disease and its impact on humans and animals. Adv. Virus Res. 1999, 53:89-110.
11. Bessoles S., Ni M., Garcia-Jimenez S., Sanchez F., Lafont V. Role of NKG2D and its ligands in the anti-infectious activity of Vgamma9Vdelta2T cells against intracellular bacteria. Eur. J. Immunol. 2011, 41:1619-1628.
12. Bikker F.J., Ligtenberg A.J., End C., Renner M., Blaich S., Lyer S., Wittig R., van't Hof W., Veerman E.C., Nazmi K., de Blieck-Hogervorst J.M., Kioschis P., Nieuw Amerongen A.V., Poustka A., Mollenhauer J. Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains. J. Biol. Chem. 2004, 279:47699-47703.
13. Blumerman S.L., Herzig C.T., Baldwin C.L. WC1+ gammadelta T cell memory population is induced by killed bacterial vaccine. Eur. J. Immunol. 2007, 37:1204-1216.
14. Blumerman S.L., Herzig C.T., Rogers A.N., Telfer J.C., Baldwin C.L. Differential TCR gene usage between WC1- and WC1+ ruminant gammadelta T cell subpopulations including those responding to bacterial antigen. Immunogenetics 2006, 58:680-692.
15. Bonneville M., O'Brien R.L., Born W.K. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat. Rev. Immunol. 2010, 10:467-478.
16. Bonyhadi M., Weiss A., Tucker P.W., Tigelaar R.E., Allison J.P. Delta is the Cx-gene product in the gamma/delta antigen receptor of dendritic epidermal cells. Nature 1987, 330:574-576.
17. Born W., Miles C., White J., O'Brien R., Freed J.H., Marrack P., Kappler J., Kubo R.T. Peptide sequences of T-cell receptor delta and gamma chains are identical to predicted X and gamma proteins. Nature 1987, 330:572-574.
18. Brandes M., Willimann K., Moser B. Professional antigen-presentation function by human gammadelta T cells. Science 2005, 309:264-268.
19. Brenner D.J., Kaufmann A.F., Sulzer K.R., Steigerwalt A.G., Rogers F.C., Weyant R.S. Further determination of DNA relatedness between serogroups and serovars in the family Leptospiraceae with a proposal for Leptospira alexanderi sp. nov. and four new Leptospira genomospecies. Int. J. Syst. Bacteriol. 1999, 49 Pt 2:839-858.
20. Brenner M.B., McLean J., Dialynas D.P., Strominger J.L., Smith J.A., Owen F.L., Seidman J.G., Ip S., Rosen F., Krangel M.S. Identification of a putative second T-cell receptor. Nature 1986, 322:145-149.
21. Brown R.A., Blumerman S., Gay C., Bolin C., Duby R., Baldwin C.L. Comparison of three different leptospiral vaccines for induction of a type 1 immune response to Leptospira borgpetersenii serovar Hardjo. Vaccine 2003, 21:4448-4458.
22. Buddle B.M. Vaccination of cattle against Mycobacterium bovis. Tuberculosis (Edinb) 2001, 81:125-132.
23. Buddle B.M., Skinner M.A., Wedlock D.N., de Lisle G.W., Vordermeier H.M., Glyn Hewinson R. Cattle as a model for development of vaccines against human tuberculosis. Tuberculosis (Edinb) 2005, 85:19-24.
24. Buddle B.M., Wedlock D.N., Parlane N.A., Corner L.A., De Lisle G.W., Skinner M.A. Revaccination of neonatal calves with Mycobacterium bovis BCG reduces the level of protection against bovine tuberculosis induced by a single vaccination. Infect. Immun. 2003, 71:6411-6419.
25. Buza J., Kiros T., Zerihun A., Abraham I., Ameni G. Vaccination of calves with Mycobacteria bovis Bacilli Calmete Guerin (BCG) induced rapid increase in the proportion of peripheral blood gammadelta T cells. Vet. Immunol. Immunopathol. 2009, 130:251-255.
26. Carr M.M., Howard C.J., Sopp P., Manser J.M., Parsons K.R. Expression on porcine gamma delta lymphocytes of a phylogenetically conserved surface antigen previously restricted in expression to ruminant gamma delta T lymphocytes. Immunology 1994, 81:36-40.
27. Chen C., Herzig C.T., Alexander L.J., Keele J.W., McDaneld T.G., Telfer J.C., Baldwin C.L. Gene number determination and genetic polymorphism of the gamma delta T cell co-receptor WC1 genes. BMC Genet. 2012, 13:86.
28. Chen C., Herzig C.T., Telfer J.C., Baldwin C.L. Antigenic basis of diversity in the gammadelta T cell co-receptor WC1 family. Mol. Immunol. 2009, 46:2565-2575.
29. Chen C., Hsu H., Hudgens E., Telfer J.C., Baldwin C.L. Signal transduction by different forms of the gammadelta T cell-specific pattern recognition receptor WC1. J. Immunol. 2014, 193:379-390.
30. Chen Z.W. Multifunctional immune responses of HMBPP-specific Vgamma2Vdelta2T cells in M. tuberculosis and other infections. Cell. Mol. Immunol. 2013, 10:58-64.
31. Chien Y.H., Iwashima M., Kaplan K.B., Elliott J.F., Davis M.M. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature 1987, 327:677-682.
32. Chien Y.H., Konigshofer Y. Antigen recognition by gammadelta T cells. Immunol. Rev. 2007, 215:46-58.
33. Clevers H., MacHugh N.D., Bensaid A., Dunlap S., Baldwin C.L., Kaushal A., Iams K., Howard C.J., Morrison W.I. Identification of a bovine surface antigen uniquely expressed on CD4-CD8-T cell receptor gamma/delta+ T lymphocytes. Eur. J. Immunol. 1990, 20:809-817.
34. Collins R.A., Werling D., Duggan S.E., Bland A.P., Parsons K.R., Howard C.J. Gammadelta T cells present antigen to CD4+ alphabeta T cells. J. Leukoc. Biol. 1998, 63:707-714.
35. Conrad M.L., Mawer M.A., Lefranc M.P., McKinnell L., Whitehead J., Davis S.K., Pettman R., Koop B.F. The genomic sequence of the bovine T cell receptor gamma TRG loci and localization of the TRGC5 cassette. Vet. Immunol. Immunopathol. 2007, 115:346-356.
36. Daubenberger C.A., Taracha E.L., Gaidulis L., Davis W.C., McKeever D.J. Bovine gammadelta T-cell responses to the intracellular protozoan parasite Theileria parva. Infect. Immun. 1999, 67:2241-2249.
37. Davis W.C., Brown W.C., Hamilton M.J., Wyatt C.R., Orden J.A., Khalid A.M., Naessens J. Analysis of monoclonal antibodies specific for the gamma delta TcR. Vet. Immunol. Immunopathol. 1996, 52:275-283.
38. Deetz C.O., Hebbeler A.M., Propp N.A., Cairo C., Tikhonov I., Pauza C.D. Gamma interferon secretion by human Vgamma2Vdelta2T cells after stimulation with antibody against the T-cell receptor plus the toll-like receptor 2 agonist Pam3Cys. Infect. Immun. 2006, 74:4505-4511.
39. Dobromylskyj M., Ellis S. Complexity in cattle KIR genes: transcription and genome analysis. Immunogenetics 2007, 59:463-472.
40. Doherty M.L., Bassett H.F., Quinn P.J., Davis W.C., Kelly A.P., Monaghan M.L. A sequential study of the bovine tuberculin reaction. Immunology 1996, 87:9-14.
41. Eisenreich W., Bacher A., Arigoni D., Rohdich F. Biosynthesis of isoprenoids via the non-mevalonate pathway. Cell. Mol. Life Sci. 2004, 61:1401-1426.
42. Ellis J.A., Baldwin C.L., MacHugh N.D., Bensaid A., Teale A.J., Goddeeris B.M., Morrison W.I. Characterization by a monoclonal antibody and functional analysis of a subset of bovine T lymphocytes that express BoT8, a molecule analogous to human CD8. Immunology 1986, 58:351-358.
43. Ellis W.A. Leptospirosis as a cause of reproductive failure. Vet. Clin. North Am. Food Anim. Pract. 1994, 10:463-478.
44. Ellis W.A., O'Brien J.J., Bryson D.G., Mackie D.P. Bovine leptospirosis: some clinical features of serovar hardjo infection. Vet. Rec. 1985, 117:101-104.
45. Elsik C.G., Tellam R.L., Worley K.C., Gibbs R.A., Muzny D.M., Weinstock G.M., Adelson D.L., Eichler E.E., Elnitski L., Guigo R., Hamernik D.L., Kappes S.M., Lewin H.A., Lynn D.J., Nicholas F.W., Reymond A., Rijnkels M., Skow L.C., Zdobnov E.M., Schook L., Womack J., Alioto T., Antonarakis S.E., Astashyn A., Chapple C.E., Chen H.C., Chrast J., Camara F., Ermolaeva O., Henrichsen C.N., Hlavina W., Kapustin Y., Kiryutin B., Kitts P., Kokocinski F., Landrum M., Maglott D., Pruitt K., Sapojnikov V., Searle S.M., Solovyev V., Souvorov A., Ucla C., Wyss C., Anzola J.M., Gerlach D., Elhaik E., Graur D., Reese J.T., Edgar R.C., McEwan J.C., Payne G.M., Raison J.M., Junier T., Kriventseva E.V., Eyras E., Plass M., Donthu R., Larkin D.M., Reecy J., Yang M.Q., Chen L., Cheng Z., Chitko-McKown C.G., Liu G.E., Matukumalli L.K., Song J., Zhu B., Bradley D.G., Brinkman F.S., Lau L.P., Whiteside M.D., Walker A., Wheeler T.T., Casey T., German J.B., Lemay D.G., Maqbool N.J., Molenaar A.J., Seo S., Stothard P., Baldwin C.L., Baxter R., Brinkmeyer-Langford C.L., Brown W.C., Childers C.P., Connelley T., Ellis S.A., Fritz K., Glass E.J., Herzig C.T., Iivanainen A., Lahmers K.K., Bennett A.K., Dickens C.M., Gilbert J.G., Hagen D.E., Salih H., Aerts J., Caetano A.R., et al. The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science 2009, 324:522-528.
46. End C., Bikker F., Renner M., Bergmann G., Lyer S., Blaich S., Hudler M., Helmke B., Gassler N., Autschbach F., Ligtenberg A.J., Benner A., Holmskov U., Schirmacher P., Nieuw Amerongen A.V., Rosenstiel P., Sina C., Franke A., Hafner M., Kioschis P., Schreiber S., Poustka A., Mollenhauer J. DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands. Eur. J. Immunol. 2009, 39:833-842.
47. Fabriek B.O., van Bruggen R., Deng D.M., Ligtenberg A.J., Nazmi K., Schornagel K., Vloet R.P., Dijkstra C.D., van den Berg T.K. The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria. Blood 2009, 113:887-892.
48. Fisher C.A., Bhattarai E.K., Osterstock J.B., Dowd S.E., Seabury P.M., Vikram M., Whitlock R.H., Schukken Y.H., Schnabel R.D., Taylor J.F., Womack J.E., Seabury C.M. Evolution of the bovine TLR gene family and member associations with Mycobacterium avium subspecies paratuberculosis infection. PLoS ONE 2011, 6:e27744.
49. Goddeeris B.M., Morrison W.I., Naessens J., Magondu J.G. The bovine autologous mixed leukocyte reaction: a proliferative response of non-T cells under the control of monocytes. Immunobiology 1987, 176:47-62.
50. Griebel P.J., Hein W.R. Expanding the role of Peyer's patches in B-cell ontogeny. Immunol. Today 1996, 17:30-39.
51. Groh V., Steinle A., Bauer S., Spies T. Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science 1998, 279:1737-1740.
52. Guethlein L.A., Abi-Rached L., Hammond J.A., Parham P. The expanded cattle KIR genes are orthologous to the conserved single-copy KIR3DX1 gene of primates. Immunogenetics 2007, 59:517-522.
53. Guy-Grand D., Cerf-Bensussan N., Malissen B., Malassis-Seris M., Briottet C., Vassalli P. Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med. 1991, 173:471-481.
54. Guy-Grand D., Vassalli P. Gut intraepithelial T lymphocytes. Curr. Opin. Immunol. 1993, 5:247-252.
55. Guzman E., Birch J.R., Ellis S.A. Cattle MIC is a ligand for the activating NK cell receptor NKG2D. Vet. Immunol. Immunopathol. 2010, 136:227-234.
56. Guzman E., Hope J., Taylor G., Smith A.L., Cubillos-Zapata C., Charleston B. Bovine gammadelta T cells are a major regulatory T cell subset. J. Immunol. 2014, 193:208-222.
57. Guzman E., Price S., Poulsom H., Hope J. Bovine gammadelta T cells: cells with multiple functions and important roles in immunity. Vet. Immunol. Immunopathol. 2012, 148:161-167.
58. Hanby-Flarida M.D., Trask O.J., Yang T.J., Baldwin C.L. Modulation of WC1, a lineage-specific cell surface molecule of gamma/delta T cells augments cellular proliferation. Immunology 1996, 88:116-123.
59. Harly C., Guillaume Y., Nedellec S., Peigne C.M., Monkkonen H., Monkkonen J., Li J., Kuball J., Adams E.J., Netzer S., Dechanet-Merville J., Leger A., Herrmann T., Breathnach R., Olive D., Bonneville M., Scotet E. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human gammadelta T-cell subset. Blood 2012, 120:2269-2279.
60. Hata S., Brenner M.B., Krangel M.S. Identification of putative human T cell receptor delta complementary DNA clones. Science 1987, 238:678-682.
61. Havran W.L., Allison J.P. Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature 1988, 335:443-445.
62. Hayday A.C. [gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 2000, 18:975-1026.
63. Hayday A.C., Saito H., Gillies S.D., Kranz D.M., Tanigawa G., Eisen H.N., Tonegawa S. Structure, organization, and somatic rearrangement of T cell gamma genes. Cell 1985, 40:259-269.
64. Hedges J.F., Buckner D.L., Rask K.M., Kerns H.M., Jackiw L.O., Trunkle T.C., Pascual D.W., Jutila M.A. Mucosal lymphatic-derived gammadelta T cells respond early to experimental Salmonella enterocolitis by increasing expression of IL-2R alpha. Cell. Immunol. 2007, 246:8-16.
65. Hedges J.F., Cockrell D., Jackiw L., Meissner N., Jutila M.A. Differential mRNA expression in circulating gammadelta T lymphocyte subsets defines unique tissue-specific functions. J. Leukoc. Biol. 2003, 73:306-314.
66. Hedges J.F., Lubick K.J., Jutila M.A. Gamma delta T cells respond directly to pathogen-associated molecular patterns. J. Immunol. 2005, 174:6045-6053.
67. Hein W.R., Dudler L. Divergent evolution of T cell repertoires: extensive diversity and developmentally regulated expression of the sheep gamma delta T cell receptor. EMBO J. 1993, 12:715-724.
68. Hein W.R., Griebel P.J. A road less travelled: large animal models in immunological research. Nat. Rev. Immunol. 2003, 3:79-84.
69. Hein W.R., Mackay C.R. Prominence of gamma delta T cells in the ruminant immune system. Immunol. Today 1991, 12:30-34.
70. Herzig C., Blumerman S., Lefranc M.P., Baldwin C. Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells. Immunogenetics 2006, 58:138-151.
71. Herzig C.T., Baldwin C.L. Genomic organization and classification of the bovine WC1 genes and expression by peripheral blood gamma delta T cells. BMC Genomics 2009, 10:191.
72. Herzig C.T., Blumerman S.L., Baldwin C.L. Identification of three new bovine T-cell receptor delta variable gene subgroups expressed by peripheral blood T cells. Immunogenetics 2006, 58:746-757.
73. Herzig C.T., Lefranc M.P., Baldwin C.L. Annotation and classification of the bovine T cell receptor delta genes. BMC Genomics 2010, 11:100.
74. Herzig C.T., Waters R.W., Baldwin C.L., Telfer J.C. Evolution of the CD163 family and its relationship to the bovine gamma delta T cell co-receptor WC1. BMC Evol. Biol. 2010, 10:181.
75. Herzig C.T.A., Baldwin C.L. Genomic organization and classification of the bovine WC1 genes and expression by peripheral blood gamma delta T cells. BMC Genomics 2009, 10:191.
76. Hoek A., Rutten V.P., Kool J., Arkesteijn G.J., Bouwstra R.J., Van Rhijn I., Koets A.P. Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo. Vet. Res. 2009, 40:6.
77. Hogg A.E., Parsons K., Taylor G., Worth A., Beverley P., Howard C.J., Villarreal-Ramos B. Characterization of age-related changes in bovine CD8+ T-cells. Vet. Immunol. Immunopathol. 2011, 140:47-54.
78. Hope J.C., Guzman E., Cubillos-Zapata C., Stephens S.A., Gilbert S.C., Prentice H., Sopp P., Howard C.J., Charleston B. Migratory sub-populations of afferent lymphatic dendritic cells differ in their interactions with Mycobacterium bovis Bacille Calmette Guerin. Vaccine 2012, 30:2357-2367.
79. Hope J.C., Thom M.L., Villarreal-Ramos B., Vordermeier H.M., Hewinson R.G., Howard C.J. Vaccination of neonatal calves with Mycobacterium bovis BCG induces protection against intranasal challenge with virulent M. bovis. Clin. Exp. Immunol. 2005, 139:48-56.
80. Hsu, H., Chen, C., Nenninger, A., Holz, L., Baldwin, C., Telfer, J.C., in press. WC1 is a hybrid gamma delta TCR coreceptor and pattern recognition receptor for pathogenic bacteria. J. Immunol.
81. Huang D., Chen C.Y., Zhang M., Qiu L., Shen Y., Du G., Zhou K., Wang R., Chen Z.W. Clonal immune responses of Mycobacterium-specific gammadelta T cells in tuberculous and non-tuberculous tissues during M. tuberculosis infection. PLoS ONE 2012, 7:e30631.
82. Imanishi T., Hara H., Suzuki S., Suzuki N., Akira S., Saito T. Cutting edge: TLR2 directly triggers Th1 effector functions. J. Immunol. 2007, 178:6715-6719.
83. Janes P.W., Ley S.C., Magee A.I., Kabouridis P.S. The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin. Immunol. 2000, 12:23-34.
84. Kennedy H.E., Welsh M.D., Bryson D.G., Cassidy J.P., Forster F.I., Howard C.J., Collins R.A., Pollock J.M. Modulation of immune responses to Mycobacterium bovis in cattle depleted of WC1(+) gamma delta T cells. Infect. Immun. 2002, 70:1488-1500.
85. Klimpel G.R., Matthias M.A., Vinetz J.M. Leptospira interrogans activation of human peripheral blood mononuclear cells: preferential expansion of TCR gamma delta+ T cells vs TCR alpha beta+ T cells. J. Immunol. 2003, 171:1447-1455.
86. Koets A., Rutten V., Hoek A., van Mil F., Muller K., Bakker D., Gruys E., van Eden W. Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function. Infect. Immun. 2002, 70:3856-3864.
87. Kydd J., Antczak D.F., Allen W.R., Barbis D., Butcher G., Davis W., Duffus W.P., Edington N., Grunig G., Holmes M.A., et al. Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, UK, July 1991. Vet. Immunol. Immunopathol. 1994, 42:3-60.
88. Lahmers K.K., Hedges J.F., Jutila M.A., Deng M., Abrahamsen M.S., Brown W.C. Comparative gene expression by WC1+ gammadelta and CD4+ alphabeta T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ gammadelta T cells. J. Leukoc. Biol. 2006, 80:939-952.
89. Lahmers K.K., Norimine J., Abrahamsen M.S., Palmer G.H., Brown W.C. The CD4+ T cell immunodominant Anaplasma marginale major surface protein 2 stimulates gammadelta T cell clones that express unique T cell receptors. J. Leukoc. Biol. 2005, 77:199-208.
90. Lau C., Smythe L., Weinstein P. Leptospirosis: an emerging disease in travellers. Travel Med. Infect. Dis. 2010, 8:33-39.
91. Lee J., Choi K., Olin M.R., Cho S.N., Molitor T.W. Gammadelta T cells in immunity induced by Mycobacterium bovis bacillus Calmette-Guerin vaccination. Infect. Immun. 2004, 72:1504-1511.
92. Ligtenberg A.J., Veerman E.C., Nieuw Amerongen A.V., Mollenhauer J. Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer. Biol. Chem. 2007, 388:1275-1289.
93. Loh E.Y., Lanier L.L., Turck C.W., Littman D.R., Davis M.M., Chien Y.H., Weiss A. Identification and sequence of a fourth human T cell antigen receptor chain. Nature 1987, 330:569-572.
94. Luoma A.M., Castro C.D., Mayassi T., Bembinster L.A., Bai L., Picard D., Anderson B., Scharf L., Kung J.E., Sibener L.V., Savage P.B., Jabri B., Bendelac A., Adams E.J. Crystal structure of Vdelta1T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human gammadelta T cells. Immunity 2013, 39:1032-1042.
95. MacHugh N.D., Bensaid A., Howard C.J., Davis W.C., Morrison W.I. Analysis of the reactivity of anti-bovine CD8 monoclonal antibodies with cloned T cell lines and mouse L-cells transfected with bovine CD8. Vet. Immunol. Immunopathol. 1991, 27:169-172.
96. Machugh N.D., Mburu J.K., Carol M.J., Wyatt C.R., Orden J.A., Davis W.C. Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution. Immunology 1997, 92:340-345.
97. Mackay C.R., Beya M.F., Matzinger P. Gamma/delta T cells express a unique surface molecule appearing late during thymic development. Eur. J. Immunol. 1989, 19:1477-1483.
98. Mackay C.R., Hein W.R. A large proportion of bovine T cells express the gamma delta T cell receptor and show a distinct tissue distribution and surface phenotype. Int. Immunol. 1989, 1:540-545.
99. Mackay C.R., Maddox J.F., Brandon M.R. Three distinct subpopulations of sheep T lymphocytes. Eur. J. Immunol. 1986, 16:19-25.
100. Maddox J.F., Mackay C.R., Brandon M.R. Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen. Immunology 1987, 62:107-112.
101. Mariner J.C., House J.A., Sollod A.E., Stem C., van den Ende M., Mebus C.A. Comparison of the effect of various chemical stabilizers and lyophilization cycles on the thermostability of a Vero cell-adapted rinderpest vaccine. Vet. Microbiol. 1990, 21:195-209.
102. Martin B., Hirota K., Cua D.J., Stockinger B., Veldhoen M. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 2009, 31:321-330.
103. Martino A., Casetti R., Sacchi A., Poccia F. Central memory Vgamma9Vdelta2T lymphocytes primed and expanded by bacillus Calmette-Guerin-infected dendritic cells kill mycobacterial-infected monocytes. J. Immunol. 2007, 179:3057-3064.
104. Martino A., Poccia F. Gamma delta T cells and dendritic cells: close partners and biological adjuvants for new therapies. Curr. Mol. Med. 2007, 7:658-673.
105. Matthews K.E., Mueller S.G., Woods C., Bell D.N. Expression of the hemoglobin-haptoglobin receptor CD163 on hematopoietic progenitors. Stem Cells Dev. 2006, 15:40-48.
106. McGill J.L., Nonnecke B.J., Lippolis J.D., Reinhardt T.A., Sacco R.E. Differential chemokine and cytokine production by neonatal bovine gammadelta T-cell subsets in response to viral toll-like receptor agonists and in vivo respiratory syncytial virus infection. Immunology 2013, 139:227-244.
107. McGill J.L., Sacco R.E., Baldwin C.L., Telfer J.C., Palmer M.V., Waters W.R. Specific recognition of mycobacterial protein and peptide antigens by gammadelta T cell subsets following infection with virulent Mycobacterium bovis. J. Immunol. 2014, 192:2756-2769.
108. McQueen K.L., Wilhelm B.T., Harden K.D., Mager D.L. Evolution of NK receptors: a single Ly49 and multiple KIR genes in the cow. Eur. J. Immunol. 2002, 32:810-817.
109. Meissner N., Radke J., Hedges J.F., White M., Behnke M., Bertolino S., Abrahamsen M., Jutila M.A. Serial analysis of gene expression in circulating gamma delta T cell subsets defines distinct immunoregulatory phenotypes and unexpected gene expression profiles. J. Immunol. 2003, 170:356-364.
110. Menzies M., Ingham A. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Vet. Immunol. Immunopathol. 2006, 109:23-30.
111. Miccoli M.C., Antonacci R., Vaccarelli G., Lanave C., Massari S., Cribiu E.P., Ciccarese S. Evolution of TRG clusters in cattle and sheep genomes as drawn from the structural analysis of the ovine TRG2@ locus. J. Mol. Evol. 2003, 57:52-62.
112. Miyasaka M., Trnka Z. Lymphocyte migration and differentiation in a large-animal model: the sheep. Immunol. Rev. 1986, 91:87-114.
113. Moody D.B., Ulrichs T., Muhlecker W., Young D.C., Gurcha S.S., Grant E., Rosat J.P., Brenner M.B., Costello C.E., Besra G.S., Porcelli S.A. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature 2000, 404:884-888.
114. Morita C.T., Jin C., Sarikonda G., Wang H. Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol. Rev. 2007, 215:59-76.
115. Morrison W.I., Davis W.C. Individual antigens of cattle. Differentiation antigens expressed predominantly on CD4- CD8-T lymphocytes (WC1, WC2). Vet. Immunol. Immunopathol. 1991, 27:71-76.
116. Murphy A.G., O'Keeffe K.M., Lalor S.J., Maher B.M., Mills K.H., McLoughlin R.M. Staphylococcus aureus infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection. J. Immunol. 2014, 192:3697-3708.
117. Naessens J., Newson J., McHugh N., Howard C.J., Parsons K., Jones B. Characterization of a bovine leucocyte differentiation antigen of 145,000MW restricted to B lymphocytes. Immunology 1990, 69:525-530.
118. Nagaeva O., Jonsson L., Mincheva-Nilsson L. Dominant IL-10 and TGF-beta mRNA expression in gammadeltaT cells of human early pregnancy decidua suggests immunoregulatory potential. Am. J. Reprod. Immunol. 2002, 48:9-17.
119. Naiman B.M., Alt D., Bolin C.A., Zuerner R., Baldwin C.L. Protective killed Leptospira borgpetersenii vaccine induces potent Th1 immunity comprising responses by CD4 and gammadelta T lymphocytes. Infect. Immun. 2001, 69:7550-7558.
120. Okamoto Yoshida Y., Umemura M., Yahagi A., O'Brien R.L., Ikuta K., Kishihara K., Hara H., Nakae S., Iwakura Y., Matsuzaki G. Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J. Immunol. 2010, 184:4414-4422.
121. Okragly A.J., Hanby-Flarida M., Mann D., Baldwin C.L. Bovine gamma/delta T-cell proliferation is associated with self-derived molecules constitutively expressed in vivo on mononuclear phagocytes. Immunology 1996, 87:71-79.
122. Owen R.D. Immunogenetic consequences of vascular anastomoses between bovine twins. Science 1945, 102:400-401.
123. Palakodeti A., Sandstrom A., Sundaresan L., Harly C., Nedellec S., Olive D., Scotet E., Bonneville M., Adams E.J. The molecular basis for modulation of human V(9V(2T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J. Biol. Chem. 2012, 287:32780-32790.
124. Palmer M.V., Stasko J., Waters W.R., Thacker T.C. Examination of the reticular epithelium of the bovine pharyngeal tonsil. Anat. Rec. (Hoboken) 2011, 294:1939-1950.
125. Palmer M.V., Waters W.R., Thacker T.C. Lesion development and immunohistochemical changes in granulomas from cattle experimentally infected with Mycobacterium bovis. Vet. Pathol. 2007, 44:863-874.
126. Pappas G., Papadimitriou P., Siozopoulou V., Christou L., Akritidis N. The globalization of leptospirosis: worldwide incidence trends. Int. J. Infect. Dis. 2008, 12:351-357.
127. Park Y.H., Fox L.K., Hamilton M.J., Davis W.C. Bovine mononuclear leukocyte subpopulations in peripheral blood and mammary gland secretions during lactation. J. Dairy Sci. 1992, 75:998-1006.
128. Parng C.L., Hansal S., Goldsby R.A., Osborne B.A. Gene conversion contributes to Ig light chain diversity in cattle. J. Immunol. 1996, 157:5478-5486.
129. Pieper J., Methner U., Berndt A. Characterization of avian gammadelta T-cell subsets after Salmonella enterica serovar Typhimurium infection of chicks. Infect. Immun. 2011, 79:822-829.
130. Pinder M., Musoke A.J., Morrison W.I., Roelants G.E. The bovine lymphoid system. III. A monoclonal antibody specific for bovine cell surface and serum IgM. Immunology 1980, 40:359-365.
131. Plattner B.L., Doyle R.T., Hostetter J.M. Gamma-delta T cell subsets are differentially associated with granuloma development and organization in a bovine model of mycobacterial disease. Int. J. Exp. Pathol. 2009, 90:587-597.
132. Plattner B.L., Huffman E.L., Hostetter J.M. Gamma-delta T-cell responses during subcutaneous Mycobacterium avium subspecies paratuberculosis challenge in sensitized or naive calves using matrix biopolymers. Vet. Pathol. 2013, 50:630-637.
133. Price S., Davies M., Villarreal-Ramos B., Hope J. Differential distribution of WC1(+) gammadelta TCR(+) T lymphocyte subsets within lymphoid tissues of the head and respiratory tract and effects of intranasal M. bovis BCG vaccination. Vet. Immunol. Immunopathol. 2010, 136:133-137.
134. Price S.J., Hope J.C. Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signals. Immunology 2009, 126:201-208.
135. Reynaud C.A., Anquez V., Dahan A., Weill J.C. A single rearrangement event generates most of the chicken immunoglobulin light chain diversity. Cell 1985, 40:283-291.
136. Rhodes S.G., Hewinson R.G., Vordermeier H.M. Antigen recognition and immunomodulation by gamma delta T cells in bovine tuberculosis. J. Immunol. 2001, 166:5604-5610.
137. Ribot J.C., debarros A., Silva-Santos B. Searching for "signal 2": costimulation requirements of gammadelta T cells. Cell. Mol. Life Sci 2011, 68:2345-2355.
138. Rodwell T.C., Moore M., Moser K.S., Brodine S.K., Strathdee S.A. Tuberculosis from Mycobacterium bovis in binational communities, United States. Emerg. Infect. Dis. 2008, 14:909-916.
139. Rogers A.N., Vanburen D.G., Hedblom E.E., Tilahun M.E., Telfer J.C., Baldwin C.L. Gammadelta T cell function varies with the expressed WC1 coreceptor. J. Immunol. 2005, 174:3386-3393.
140. Rogers A.N., Vanburen D.G., Zou B., Lahmers K.K., Herzig C.T., Brown W.C., Telfer J.C., Baldwin C.L. Characterization of WC1 co-receptors on functionally distinct subpopulations of ruminant gamma delta T cells. Cell. Immunol. 2006, 239:151-161.
141. Rossi C.R., Kiesel G.K., Kramer T.T., Hudson R.S. Cell-mediated and humoral immune responses of cattle to Brucella abortus. Mycobacterium bovis, and tetanus toxoid: immunization of the fetus. Am. J. Vet. Res. 1978, 39:1742-1747.
142. Saito H., Kranz D.M., Takagaki Y., Hayday A.C., Eisen H.N., Tonegawa S. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature 1984, 312:36-40.
143. Sarrias M.R., Gronlund J., Padilla O., Madsen J., Holmskov U., Lozano F. The scavenger receptor cysteine-rich (SRCR) domain: an ancient and highly conserved protein module of the innate immune system. Crit. Rev. Immunol. 2004, 24:1-37.
144. Sarrias M.R., Rosello S., Sanchez-Barbero F., Sierra J.M., Vila J., Yelamos J., Vives J., Casals C., Lozano F. A role for human Sp alpha as a pattern recognition receptor. J. Biol. Chem. 2005, 280:35391-35398.
145. Sathiyaseelan T., Naiman B., Welte S., Machugh N., Black S.J., Baldwin C.L. Immunological characterization of a gammadelta T-cell stimulatory ligand on autologous monocytes. Immunology 2002, 105:181-189.
146. Shen Y., Zhou D., Qiu L., Lai X., Simon M., Shen L., Kou Z., Wang Q., Jiang L., Estep J., Hunt R., Clagett M., Sehgal P.K., Li Y., Zeng X., Morita C.T., Brenner M.B., Letvin N.L., Chen Z.W. Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections. Science 2002, 295:2255-2258.
147. Sheridan B.S., Romagnoli P.A., Pham Q.M., Fu H.H., Alonzo F., Schubert W.D., Freitag N.E., Lefrancois L. gammadelta T cells exhibit multifunctional and protective memory in intestinal tissues. Immunity 2013, 39:184-195.
148. Shin S., El-Diwany R., Schaffert S., Adams E.J., Garcia K.C., Pereira P., Chien Y.H. Antigen recognition determinants of gammadelta T cell receptors. Science 2005, 308:252-255.
149. Sinkora M., Butler J.E. The ontogeny of the porcine immune system. Dev. Comp. Immunol. 2009, 33:273-283.
150. Smyth A.J., Welsh M.D., Girvin R.M., Pollock J.M. In vitro responsiveness of gammadelta T cells from Mycobacterium bovis-infected cattle to mycobacterial antigens: predominant involvement of WC1(+) cells. Infect. Immun. 2001, 69:89-96.
151. Sopp P., Howard C.J., Parsons K.R. Investigating monoclonal antibodies to bovine "null" cell antigens using two-colour immunofluorescence. Vet. Immunol. Immunopathol. 1991, 27:163-168.
152. Storset A.K., Slettedal I.O., Williams J.L., Law A., Dissen E. Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. Eur. J. Immunol. 2003, 33:980-990.
153. Sun L., Song Y., Riaz H., Yang H., Hua G., Guo A., Yang L. Polymorphisms in toll-like receptor 1 and 9 genes and their association with tuberculosis susceptibility in Chinese Holstein cattle. Vet. Immunol. Immunopathol. 2012, 147:195-201.
154. Takamatsu H.H., Denyer M.S., Stirling C., Cox S., Aggarwal N., Dash P., Wileman T.E., Barnett P.V. Porcine gammadelta T cells: possible roles on the innate and adaptive immune responses following virus infection. Vet. Immunol. Immunopathol. 2006, 112:49-61.
155. Tanaka Y., Sano S., Nieves E., De Libero G., Rosa D., Modlin R.L., Brenner M.B., Bloom B.R., Morita C.T. Nonpeptide ligands for human gamma delta T cells. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:8175-8179.
156. Tierney T.J., Simpson-Morgan M.W. The immune response of foetal calves. Vet. Immunol. Immunopathol. 1997, 57:229-238.
157. Tuo W., Bazer F.W., Davis W.C., Zhu D., Brown W.C. Differential effects of type I IFNs on the growth of WC1- CD8+ gamma delta T cells and WC1+ CD8- gamma delta T cells in vitro. J. Immunol. 1999, 162:245-253.
158. Valdez R.A., McGuire T.C., Brown W.C., Davis W.C., Knowles D.P. Long-term in vivo depletion of functional CD4+ T lymphocytes from calves requires both thymectomy and anti-CD4 monoclonal antibody treatment. Immunology 2001, 102:426-433.
159. van Pinxteren L.A., Ravn P., Agger E.M., Pollock J., Andersen P. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10. Clin. Diagn. Lab. Immunol. 2000, 7:155-160.
160. Van Rhijn I., Godfroid J., Michel A., Rutten V. Bovine tuberculosis as a model for human tuberculosis: advantages over small animal models. Microbes Infect. 2008, 10:711-715.
161. Van Rhijn I., Koets A.P., Im J.S., Piebes D., Reddington F., Besra G.S., Porcelli S.A., van Eden W., Rutten V.P. The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d. J. Immunol. 2006, 176:4888-4893.
162. Van Rhijn I., Rutten V.P., Charleston B., Smits M., van Eden W., Koets A.P. Massive, sustained gammadelta T cell migration from the bovine skin in vivo. J. Leukoc. Biol. 2007, 81:968-973.
163. Van Rhijn I., Spiering R., Smits M., van Blokland M.T., de Weger R., van Eden W., Rutten V.P., Koets A.P. Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain. Mol. Immunol. 2007, 44:3155-3161.
164. Vantourout P., Hayday A. Six-of-the-best: unique contributions of gammadelta T cells to immunology. Nat. Rev. Immunol. 2013, 13:88-100.
165. Vera J., Fenutria R., Canadas O., Figueras M., Mota R., Sarrias M.R., Williams D.L., Casals C., Yelamos J., Lozano F. The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:1506-1511.
166. Vesosky B., Turner O.C., Turner J., Orme I.M. Gamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan. Infect. Immun. 2004, 72:4612-4618.
167. Vrieling M., Santema W., Van Rhijn I., Rutten V., Koets A. Gammadelta T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent. J. Immunol. 2012, 188:578-584.
168. Walker I.D., Glew M.D., O'Keeffe M.A., Metcalfe S.A., Clevers H.C., Wijngaard P.L., Adams T.E., Hein W.R. A novel multi-gene family of sheep gamma delta T cells. Immunology 1994, 83:517-523.
169. Wang F., Herzig C., Ozer D., Baldwin C.L., Telfer J.C. Tyrosine phosphorylation of scavenger receptor cysteine-rich WC1 is required for the WC1-mediated potentiation of TCR-induced T-cell proliferation. Eur. J. Immunol. 2009, 39:254-266.
170. Wang F., Herzig C.T., Chen C., Hsu H., Baldwin C.L., Telfer J.C. Scavenger receptor WC1 contributes to the gammadelta T cell response to Leptospira. Mol. Immunol. 2011, 48:801-809.
171. Wang H., Fang Z., Morita C.T. Vgamma2Vdelta2T cell receptor recognition of prenyl pyrophosphates is dependent on all CDRs. J. Immunol. 2010, 184:6209-6222.
172. Wang H., Henry O., Distefano M.D., Wang Y.C., Raikkonen J., Monkkonen J., Tanaka Y., Morita C.T. Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vgamma2Vdelta2T cells. J. Immunol. 2013, 191:1029-1042.
173. Wang S., Welte T., Fang H., Chang G.J., Born W.K., O'Brien R.L., Sun B., Fujii H., Kosuna K., Wang T. Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. J. Nutr. 2009, 139:598-602.
174. Waters W.R., Nonnecke B.J., Foote M.R., Maue A.C., Rahner T.E., Palmer M.V., Whipple D.L., Horst R.L., Estes D.M. Mycobacterium bovis bacille Calmette-Guerin vaccination of cattle: activation of bovine CD4+ and gamma delta TCR+ cells and modulation by 1,25-dihydroxyvitamin D3. Tuberculosis (Edinb) 2003, 83:287-297.
175. Waters W.R., Palmer M.V., Buddle B.M., Vordermeier H.M. Bovine tuberculosis vaccine research: historical perspectives and recent advances. Vaccine 2012, 30:2611-2622.
176. Waters W.R., Whelan A.O., Lyashchenko K.P., Greenwald R., Palmer M.V., Harris B.N., Hewinson R.G., Vordermeier H.M. Immune responses in cattle inoculated with Mycobacterium bovis. Mycobacterium tuberculosis, or Mycobacterium kansasii. Clin. Vaccine Immunol. 2010, 17:247-252.
177. Welsh M.D., Kennedy H.E., Smyth A.J., Girvin R.M., Andersen P., Pollock J.M. Responses of bovine WC1(+) gammadelta T cells to protein and nonprotein antigens of Mycobacterium bovis. Infect. Immun. 2002, 70:6114-6120.
178. Werling D., Coffey T.J. Pattern recognition receptors in companion and farm animals - the key to unlocking the door to animal disease?. Vet. J. 2007, 174:240-251.
179. Wilson E., Hedges J.F., Butcher E.C., Briskin M., Jutila M.A. Bovine gamma delta T cell subsets express distinct patterns of chemokine responsiveness and adhesion molecules: a mechanism for tissue-specific gamma delta T cell subset accumulation. J. Immunol. 2002, 169:4970-4975.
180. Wood P.R., Corner L.A., Plackett P. Development of a simple, rapid in vitro cellular assay for bovine tuberculosis based on the production of gamma interferon. Res. Vet. Sci. 1990, 49:46-49.
181. Wyatt C.R., Brackett E.J., Perryman L.E., Davis W.C. Identification of gamma delta T lymphocyte subsets that populate calf ileal mucosa after birth. Vet. Immunol. Immunopathol. 1996, 52:91-103.
182. Xu B., Pizarro J.C., Holmes M.A., McBeth C., Groh V., Spies T., Strong R.K. Crystal structure of a gammadelta T-cell receptor specific for the human MHC class I homolog MICA. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:2414-2419.
183. Yilma T., Hsu D., Jones L., Owens S., Grubman M., Mebus C., Yamanaka M., Dale B. Protection of cattle against rinderpest with vaccinia virus recombinants expressing the HA or F gene. Science 1988, 242:1058-1061.
184. Zufferey C., Germano S., Dutta B., Ritz N., Curtis N. The contribution of non-conventional T cells and NK cells in the mycobacterial-specific IFNgamma response in Bacille Calmette-Guerin (BCG)-immunized infants. PLOS ONE 2013, 8:e77334.