Highly diverse TCR δ chain repertoire in bovine tissues due to the use of up to four D segments per δ chain

Molecular Immunology

Volumn 44, Issue 12, 2007, Pages 3155-3161

  Van Rhijn, Ildiko ^a   Spiering, Rachel ^a   Smits, Mieke ^a   Blokland, Marja T M van ^b   de Weger, Roel ^b   van Eden, Willem ^a   Rutten, Victor P M G ^a   Koets, Ad P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

T cell receptor; Bos taurus; Spectratyping

Indexed keywords

COMPLEMENTARY DNA; GENOMIC DNA; NUCLEOTIDE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ANIMAL CELL; ARTICLE; BOVIDS; CONTROLLED STUDY; COW; GENE FUNCTION; GENETIC VARIABILITY; LARGE INTESTINE; LYMPH NODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SKIN; SMALL INTESTINE; SPLEEN;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; DNA, COMPLEMENTARY; GENES, T-CELL RECEPTOR DELTA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; VARIATION (GENETICS);

BOS; BOS TAURUS; BOVINAE; MURINAE; MUS;

EID: 34247206993     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.02.003     Document Type: Article

References (22)

1. Adams E.J., Chien Y.H., and Garcia K.C. Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science 308 (2005) 227-231
2. Antonacci R., Lanave C., Del Faro L., Vaccarelli G., Ciccarese S., and Massari S. Artiodactyl emergence is accompanied by the birth of an extensive pool of diverse germline TRDV1 genes. Immunogenetics 57 (2005) 254-266
3. Asarnow D.M., Kuziel W.A., Bonyhadi M., Tigelaar R.E., Tucker P.W., and Allison J.P. Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell 55 (1988) 837-847
4. Blumerman S.L., Herzig C.T., Rogers A.N., Telfer J.C., and Baldwin C.L. Differential TCR gene usage between WC1 (-) and WC1 (+) ruminant gammadelta T cell subpopulations including those responding to bacterial antigen. Immunogenetics 58 (2006) 680-692
5. Chowers Y., Holtmeier W., Harwood J., Morzycka-Wroblewska E., and Kagnoff M.F. The V delta 1 T cell receptor repertoire in human small intestine and colon. J. Exp. Med. 180 (1994) 183-190
6. Hedges J.F., Cockrell D., Jackiw L., Meissner N., and Jutila M.A. Differential mRNA expression in circulating gammadelta T lymphocyte subsets defines unique tissue-specific functions. J. Leukoc. Biol. 73 (2003) 306-314
7. Hein W.R., and Dudler L. TCR gamma delta+ cells are prominent in normal bovine skin and express a diverse repertoire of antigen receptors. Immunology 91 (1997) 58-64
8. Hein W.R., and Mackay C.R. Prominence of gamma delta T cells in the ruminant immune system. Immunol. Today 12 (1991) 30-34
9. Herzig C., Blumerman S., Lefranc M.P., and Baldwin C. Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells. Immunogenetics 58 (2006) 138-151
10. Herzig C.T., Blumerman S.L., and Baldwin C.L. Identification of three new bovine T-cell receptor delta variable gene subgroups expressed by peripheral blood T cells. Immunogenetics 58 (2006) 746-757
11. Holtmeier W., Chowers Y., Lumeng A., Morzycka-Wroblewska E., and Kagnoff M.F. The delta T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage. J. Clin. Invest. 96 (1995) 1108-1117
12. Ishiguro N., Aida Y., Shinagawa T., and Shinagawa M. Molecular structures of cattle T-cell receptor gamma and delta chains predominantly expressed on peripheral blood lymphocytes. Immunogenetics 38 (1993) 437-443
13. Itohara S., Farr A.G., Lafaille J.J., Bonneville M., Takagaki Y., Haas W., and Tonegawa S. Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia. Nature 343 (1990) 754-757
14. Machugh N.D., Mburu J.K., Carol M.J., Wyatt C.R., Orden J.A., and Davis W.C. Identification of two distinct subsets of bovine gamma delta T cells with unique cell surface phenotype and tissue distribution. Immunology 92 (1997) 340-345
15. Massari S., Antonacci R., Lanave C., and Ciccarese S. Genomic organization of sheep TRDJ segments and their expression in the delta-chain repertoire in thymus. Immunogenetics 52 (2000) 1-8
16. O'Keeffe M.A., Metcalfe S.A., Cunningham C.P., and Walker I.D. Sheep CD4(+) alphabeta T cells express novel members of the T19 multigene family. Immunogenetics 49 (1999) 45-55
17. Shin S., El-Diwany R., Schaffert S., Adams E.J., Garcia K.C., Pereira P., and Chien Y.H. Antigen recognition determinants of gammadelta T cell receptors. Science 308 (2005) 252-255
18. Uematsu Y. A novel and rapid cloning method for the T-cell receptor variable region sequences. Immunogenetics 34 (1991) 174-178
19. Van Rhijn, I., Rutten, V.P.M.G., Charleston, B., Smits, M., van Eden, W., Koets, A.P., 2007. Massive, sustained gammadelta T cell migration from the bovine skin. Mol. Immunol., in press.
20. Wilson E., Aydintug M.K., and Jutila M.A. A circulating bovine gamma delta T cell subset, which is found in large numbers in the spleen, accumulates inefficiently in an artificial site of inflammation: correlation with lack of expression of E-selectin ligands and L-selectin. J. Immunol. 162 (1999) 4914-4919
21. Wilson S.B., Kent S.C., Patton K.T., Orban T., Jackson R.A., Exley M., Porcelli S., Schatz D.A., Atkinson M.A., Balk S.P., Strominger J.L., and Hafler D.A. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 391 (1998) 177-181
22. Xu C., Zhang H., Hu H., He H., Wang Z., Xu Y., Chen H., Cao W., Zhang S., Cui L., Ba D., and He W. Gammadelta T cells recognize tumor cells via CDR3delta region. Mol. Immunol. 44 (2007) 302-310