Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 7, 2015, Pages 1561-1567

  Bharate, Sonali S ^a   Vishwakarma, Ram A ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

96 Well plate; Physiological medium; QSPR study; Shake flask method; Thermodynamic equilibrium solubility; UV detection

Indexed keywords

ACECLOFENAC; ACETYLSALICYLIC ACID; ALBENDAZOLE; AMPHOTERICIN B; ANASTROZOLE; ASCORBIC ACID; BERBERINE; BUDESONIDE; CARBAMAZEPINE; CETIRIZINE; CHLORZOXAZONE; CIPROFLOXACIN; CLARITHROMYCIN; CLOTRIMAZOLE; COLCHICINE; COLISTIN; CROCIN; CURCUMIN; DICLOFENAC; DOCETAXEL; EMBELIN; FEXOFENADINE; FLUCONAZOLE; FLURBIPROFEN; FLUTICASONE PROPIONATE; GLYCYRRHETINIC ACID; INDOMETACIN; ISONIAZID; METHANOL; UNINDEXED DRUG; DRUG;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SOLUBILITY; ENVIRONMENTAL TEMPERATURE; EQUILIBRIUM CONSTANT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE FLUID; LIQUID; MICROPLATE READER; PLATE COUNT; QUANTITATIVE STRUCTURE PROPERTY RELATION; SENSITIVITY ANALYSIS; SIMULATED FLUID; SIMULATION; SUPERNATANT; THERMODYNAMICS; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; DRUG DEVELOPMENT; SOLUBILITY;

DRUG DISCOVERY; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; THERMODYNAMICS;

EID: 84925519882     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.02.013     Document Type: Article

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