An Impaired Inflammatory Cytokine Response to Gram-Negative LPS in Human Neonates is Associated with the Defective TLR-Mediated Signaling Pathway

Journal of Clinical Immunology

Volumn 35, Issue 2, 2015, Pages 218-226

  Li, Yi Ping ^a   Yu, Sheng Lin ^b   Huang, Zhi Jian ^b   Huang, Jie ^b   Pan, Jian ^a   Feng, Xing ^b   Zhang, Xue Guang ^a   Wang, Jiang Huai ^c   Wang, Jian ^b  

^a SOOCHOW UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c Department of Medicine National University of Ireland Cork   (Ireland)

Author keywords

human neonates; Inflammatory cytokines; lipopolysaccharide; monocytes; peptidoglycan; TLR signaling pathways

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PEPTIDOGLYCAN; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE; LIPOPOLYSACCHARIDE;

ADULT; ARTICLE; BIRTH WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; DOWN REGULATION; EX VIVO STUDY; FEMALE; GESTATIONAL AGE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MONOCYTE; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL CORD BLOOD; BLOOD; GRAM NEGATIVE BACTERIUM; IMMUNOLOGY; IMMUNOPHENOTYPING; INNATE IMMUNITY; METABOLISM; MIDDLE AGED; PHENOTYPE; YOUNG ADULT;

ADULT; ANTIGENS, CD14; CYTOKINES; FEMALE; GRAM-NEGATIVE BACTERIA; HUMANS; IMMUNITY, INNATE; IMMUNOPHENOTYPING; INFANT, NEWBORN; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; MONOCYTES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; YOUNG ADULT;

EID: 84925517597     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-015-0128-6     Document Type: Article

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