Multiplex analysis of toll-like receptor-stimulated neonatal cytokine response

Neonatology

Volumn 97, Issue 3, 2010, Pages 266-273

  Caron, Justin E ^a   La Pine, Timothy R ^a   Augustine, Nancy H ^a,b   Martins, Thomas B ^b   Hill, Harry R ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b ARUP INSTITUTE FOR CLINICAL AND EXPERIMENTAL PATHOLOGY   (United States)

Author keywords

Cytokine response; Proinflammatory cytokines; Toll like receptor

Indexed keywords

CYTOKINE; FLAGELLIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; POLYINOSINIC POLYCYTIDYLIC ACID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA; ZYMOSAN;

ADULT; ARTICLE; ASSAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; NEWBORN; PRIORITY JOURNAL; PROTEIN FUNCTION; TH1 CELL; TH2 CELL; UMBILICAL CORD BLOOD;

ADULT; BLOOD CHEMICAL ANALYSIS; CYTOKINES; FETAL BLOOD; FLAGELLIN; HUMANS; IMMUNITY, INNATE; IMMUNOASSAY; INFANT, NEWBORN; LIGANDS; LIPOPEPTIDES; LIPOPOLYSACCHARIDES; POLY I-C; SEROLOGIC TESTS; TH1 CELLS; TH2 CELLS; TOLL-LIKE RECEPTORS; ZYMOSAN;

BACTERIA (MICROORGANISMS);

EID: 70849099077     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000255165     Document Type: Article

References (32)

1. Marodi L: Neonatal innate immunity to infectious agents. Infect Immun 2006; 74: 1999-2006.
2. Hill HR: Group B streptococcal infections; in Holmes KK, Mardh PA, Sparling PF (eds): Sexually Transmitted Diseases. New York, McGraw-Hill, 1990, pp 851-861.
3. Faurschou M, Borregaard N: Neutrophil granules and secretory vesicles in inflammation. Microbes Infect 2003; 5: 1317-1327.
4. Yang KD, Quie PG, Hill HR: Phagocytic system; in Ochs HD, Smith CIE, Puck JM (eds): Primary Immunodeficiency Diseases. New York, Oxford University Press, 2007, pp 103- 120.
5. Hill HR, Bohnsack JF, La Pine TR: The natural (innate) defense system; in Stiehm ER, Ochs HD, Winkelstein JA (eds): Immunologic Disorders in Infants and Children. Philadelphia, Elsevier Saunders, 2004, pp 245-272.
6. Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006; 124: 783-801.
7. Gay N, Gangloff M: Structure and function of toll-like receptors and their ligands. Annu Rev Biochem 2007; 76: 141-165.
8. Kaisho T, Akira S: Toll-like receptor function and signaling. J Allergy Clin Immunol 2006; 117: 979-987.
9. Akira S, Takeda K: Toll-like receptor signaling. Nat Rev Immunol 2004; 4: 499-511.
10. Gazzinelli RT, Denkers EY: Protozoan encounters with Toll-like receptor signaling pathways: implications for host parasitism. Nat Rev Immunol 2006; 6: 895-906.
11. Peters AM, Bertram P, Gahr M, Speer CP: Reduced secretion of interleukin-1 and tumor necrosis factor-alpha by neonatal monocytes. Biol Neonate 1993; 63: 157-162.
12. Yan SR, Qing G, Byers DM, Stadnyk AW, Al- Hertani W, Bortolussi R: Role of MyD88 in diminished tumor necrosis factor alpha production by newborn mononuclear cells in response to lipopolysaccharide. Infect Immun 2004; 72: 1223-1229.
13. Levy O, Zarember KA, Roy RM, Cywes C, Godowski PJ, Wessels MR: Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-αinduction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R- 848. J Immunol 2004; 173: 4627-4634.
14. Alves-Filho JC, de Freitas A, Russo M, Cunha FQ: Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis. Crit Care Med 2006; 34: 461-470.
15. Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais C, Dupuis S, Feinberg J, Fieschi C, Elbim C, Hitchcock R, Lammas D, Davies G, Al-Ghonaium A, Al- Rayes H, Al-Jumaah S, Al-Hajjar S, Al- Mohsen IZ, Frayha HH, Rucker R, Hawn TR, Aderem A, Tufenkeji H, Haraguchi S, Day NK, Good RA, Gougerot-Pocidalo MA, Ozinsky A, Casanova JL: Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 2003; 299: 2076-2079.
16. Bernuth HV, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz- Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL: Pyogenic bacterial infections in humans with MyD88 deficiency. Science 2008; 321: 691-696.
17. Joyner JL, Augustine NH, La Pine TR, Hill HR: Effects of group B streptococci on cord and adult mononuclear cell transcription and translation of IL-12 and IFN-γ. J Infect Dis 2000; 182: 974-977.
18. La Pine TR, Joyner JL, Augustine NH, Kwak SD, Hill HR: Defective production of IL-18 and IL-12 by cord blood mononuclear cells influences the T helper-1 interferon gamma response to group B streptococci. Pediatr Res 2003; 54: 276-281.
19. Sacchi F, Hill HR: Defective membrane potential changes in neutrophils from human neonates. J Exp Med 1984; 160: 1247-1252.
20. Hill HR, Augustine NH, Jaffe HS: Human recombinant interferon gamma enhances neonatal PMN activation and movement and increases free intracellular calcium. J Exp Med 1991; 173: 767-770.
21. Martins TB, Pasi BM, Pickering JW, Jaskowski TD, Litwin CM, Hill HR: Determination of cytokine responses using a multiplexed fluorescent microsphere immu - noassay. Am J Clin Pathol 2002; 118: 346-353.
22. Deering RP, Orange JS: Development of a clinical assay to evaluate Toll-like receptor function. Clin Vaccine Immunol 2006; 13: 68-76.
23. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin R, Akira S: Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 2002; 169: 10-14.
24. Ozinsky A, Underhill D, Fontenot J, Hajjar A, Smith K, Wilson C, SchroeDer L, Aderem A: The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc Natl Acad Sci USA 2000; 97: 13766-13771.
25. Weatherston KB, Rich EA: Tumor necrosis factor/cachectin and interleukin-1 secretion by cord blood monocytes from premature and term neonates. Pediatr Res 1989; 25: 342-346.
26. Levy O, Coughlin M, Cronstein B, Roy R, Desai A, Wessels M: The adenosine system selectively inhibits TLR-mediated TNF-αproduction in the human newborn. J Immunol 2006; 177: 1956-1966.
27. Denys A, Udalova IA, Smith C, Williams LM, Ciesielski CJ, Campbell J, Andrews C, Kwaitowski D, Foxwell BMJ: Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages. J Immunol 2002; 168: 4837-4845.
28. Brennan F: IL-10 and arthritis: Rheumatology 1999; 38: 293-297.
29. Forster-Waldl E, Sadeghi K, Tamandl D, Gerhold B, Hallwirth U, Rohrmeister K, Hayde M, Prusa AR, Herkner K, Boltz-Nitulescu G, Pollak A, Spittler A: Monocyte Toll-like receptor 4 expression and LPS-induced cytokine production increase during gestational aging. Pediatr Res 2005; 58: 121-124.
30. Viemann D, Dubbel G, Schleifenbaum S, Harms E, Sorg C, Roth J: Expression of Tolllike receptors in neonatal sepsis. Pediatr Res 2005; 58: 654-659.
31. Fleer A, Krediet ET: Innate immunity: tolllike receptors and some more. A brief history, basic organization and relevance for the human newborn. Neonatology 2007; 92: 145-157.
32. Caron JE, La Pine TR, Augustine NH, Martins TB, Hill HR: The role of Nod1 and Nod2 in the production of TNF-α, IL-1β , and IFN-γ in neonatal host defense (abstract). J Investig Med 2008; 56: 185.