메뉴 건너뛰기




Volumn 148, Issue , 2015, Pages 52-63

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation

Author keywords

DNA damage; Epidermal keratinocytes; Epidermal melanocytes; Hydroxyvitamin D; Oxidative stress; UVB

Indexed keywords

DNA; HYDROGEN PEROXIDE; NITRIC OXIDE; PROTEIN P53; PYRIMIDINE DIMER; RADIOPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; SECOSTEROID; SKIN PROTECTIVE AGENT;

EID: 84925511820     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.01.014     Document Type: Review
Times cited : (70)

References (86)
  • 1
    • 0038266168 scopus 로고    scopus 로고
    • UVB light stimulates production of reactive oxygen species: Unexpected role for catalase
    • D.E. Heck, A.M. Vetrano, T.M. Mariano, and J.D. Laskin UVB light stimulates production of reactive oxygen species: unexpected role for catalase J. Biol. Chem. 278 2003 22432 22436
    • (2003) J. Biol. Chem. , vol.278 , pp. 22432-22436
    • Heck, D.E.1    Vetrano, A.M.2    Mariano, T.M.3    Laskin, J.D.4
  • 3
    • 84255176375 scopus 로고    scopus 로고
    • UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
    • G.P. Pfeifer, and A. Besaratinia UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer Photochem. Photobiol. Sci. 11 2012 90 97
    • (2012) Photochem. Photobiol. Sci. , vol.11 , pp. 90-97
    • Pfeifer, G.P.1    Besaratinia, A.2
  • 4
    • 33748784343 scopus 로고    scopus 로고
    • Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation
    • S. Mouret, C. Baudouin, M. Charveron, A. Favier, J. Cadet, and T. Douki Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation Proc. Natl. Acad. Sci. U. S. A. 103 2006 13765 13770
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 13765-13770
    • Mouret, S.1    Baudouin, C.2    Charveron, M.3    Favier, A.4    Cadet, J.5    Douki, T.6
  • 5
    • 84879076495 scopus 로고    scopus 로고
    • DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control
    • X. Chen, J. Chen, S. Gan, H. Guan, Y. Zhou, Q. Ouyang, and J. Shi DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control BMC Biol. 11 2013 73
    • (2013) BMC Biol. , vol.11 , pp. 73
    • Chen, X.1    Chen, J.2    Gan, S.3    Guan, H.4    Zhou, Y.5    Ouyang, Q.6    Shi, J.7
  • 6
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • A.J. Levine p53, the cellular gatekeeper for growth and division Cell 88 1997 323 331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 7
    • 0027287748 scopus 로고
    • Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation
    • C. Campbell, A.G. Quinn, B. Angus, P.M. Farr, and J.L. Rees Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation Cancer Res. 53 1993 2697 2699
    • (1993) Cancer Res. , vol.53 , pp. 2697-2699
    • Campbell, C.1    Quinn, A.G.2    Angus, B.3    Farr, P.M.4    Rees, J.L.5
  • 8
    • 0001793246 scopus 로고    scopus 로고
    • P53 phosphorylation: Biochemical and functional consequences
    • G.J. Milczarek, J. Martinez, and G.T. Bowden p53 phosphorylation: biochemical and functional consequences Life Sci. 60 1997 1 11
    • (1997) Life Sci. , vol.60 , pp. 1-11
    • Milczarek, G.J.1    Martinez, J.2    Bowden, G.T.3
  • 11
    • 84862314980 scopus 로고    scopus 로고
    • Melatonin triggers p53 ser phosphorylation and prevents DNA damage accumulation
    • R. Santoro, M. Marani, G. Blandino, P. Muti, and S. Strano Melatonin triggers p53 Ser phosphorylation and prevents DNA damage accumulation Oncogene 31 2012 2931 2942
    • (2012) Oncogene , vol.31 , pp. 2931-2942
    • Santoro, R.1    Marani, M.2    Blandino, G.3    Muti, P.4    Strano, S.5
  • 13
    • 0018080938 scopus 로고
    • The photobiogenesis and metabolism of vitamin D
    • M.F. Holick, and M.B. Clark The photobiogenesis and metabolism of vitamin D Fed. Proc. 37 1978 2567 2574
    • (1978) Fed. Proc. , vol.37 , pp. 2567-2574
    • Holick, M.F.1    Clark, M.B.2
  • 14
    • 0037302906 scopus 로고    scopus 로고
    • Vitamin D: A millenium perspective
    • M.F. Holick Vitamin D: a millenium perspective J. Cell. Biochem. 88 2003 296 307
    • (2003) J. Cell. Biochem. , vol.88 , pp. 296-307
    • Holick, M.F.1
  • 15
    • 0028938524 scopus 로고
    • Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals
    • M.F. Holick, X.Q. Tian, and M. Allen Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals Proc. Natl. Acad. Sci. U. S. A. 92 1995 3124 3126
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 3124-3126
    • Holick, M.F.1    Tian, X.Q.2    Allen, M.3
  • 16
    • 77953361603 scopus 로고    scopus 로고
    • Vitamin D: Newly discovered actions require reconsideration of physiologic requirements
    • D.D. Bikle Vitamin D: newly discovered actions require reconsideration of physiologic requirements Trends Endocrinol. Metab. 21 2010 375 384
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 375-384
    • Bikle, D.D.1
  • 17
    • 77952525686 scopus 로고    scopus 로고
    • Vitamin D and the skin
    • D.D. Bikle Vitamin D and the skin J. Bone Miner. Metab. 28 2010 117 130
    • (2010) J. Bone Miner. Metab. , vol.28 , pp. 117-130
    • Bikle, D.D.1
  • 18
    • 51749107741 scopus 로고    scopus 로고
    • Vitamin D receptor, UVR, and skin cancer: A potential protective mechanism
    • Bikle Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism J. Invest. Dermatol. 128 2008 2357 2361
    • (2008) J. Invest. Dermatol. , vol.128 , pp. 2357-2361
    • Bikle1
  • 19
    • 82455162446 scopus 로고    scopus 로고
    • Vitamin D metabolism and function in the skin
    • D.D. Bikle Vitamin D metabolism and function in the skin Mol. Cell. Endocrinol. 347 2011 80 89
    • (2011) Mol. Cell. Endocrinol. , vol.347 , pp. 80-89
    • Bikle, D.D.1
  • 20
    • 34447514029 scopus 로고    scopus 로고
    • Vitamin D deficiency
    • M.F. Holick Vitamin D deficiency N. Engl. J. Med. 357 2007 266 281
    • (2007) N. Engl. J. Med. , vol.357 , pp. 266-281
    • Holick, M.F.1
  • 21
    • 78649697894 scopus 로고    scopus 로고
    • Vitamin D, disease and therapeutic opportunities
    • L.A. Plum, and H.F. DeLuca Vitamin D, disease and therapeutic opportunities Nat. Rev. Drug Discov. 9 2010 941 955
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 941-955
    • Plum, L.A.1    Deluca, H.F.2
  • 22
    • 84865330073 scopus 로고    scopus 로고
    • Structure and function of the stratum corneum extracellular matrix
    • P.M. Elias Structure and function of the stratum corneum extracellular matrix J. Invest. Dermatol. 132 2012 2131 2133
    • (2012) J. Invest. Dermatol. , vol.132 , pp. 2131-2133
    • Elias, P.M.1
  • 24
    • 77955331793 scopus 로고    scopus 로고
    • Cellular and molecular aspects of vascular dysfunction in systemic sclerosis
    • M. Trojanowska Cellular and molecular aspects of vascular dysfunction in systemic sclerosis Nat. Rev. Rheumatol. 6 2010 453 460
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 453-460
    • Trojanowska, M.1
  • 26
  • 30
    • 84863989067 scopus 로고    scopus 로고
    • Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes
    • S.K. Demetriou, K. Ona-Vu, A.E. Teichert, J.E. Cleaver, D.D. Bikle, and D.H. Oh Vitamin D receptor mediates DNA repair and is UV inducible in intact epidermis but not in cultured keratinocytes J. Invest. Dermatol. 132 2012 2097 2100
    • (2012) J. Invest. Dermatol. , vol.132 , pp. 2097-2100
    • Demetriou, S.K.1    Ona-Vu, K.2    Teichert, A.E.3    Cleaver, J.E.4    Bikle, D.D.5    Oh, D.H.6
  • 31
    • 84881175910 scopus 로고    scopus 로고
    • 1Alpha,25(OH) 2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the beta-catenin pathway
    • Y.J. Jiang, A.E. Teichert, F. Fong, Y. Oda, and D.D. Bikle 1Alpha,25(OH) 2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the beta-catenin pathway J. Steroid Biochem. Mol. Biol. 136 2013 229 232
    • (2013) J. Steroid Biochem. Mol. Biol. , vol.136 , pp. 229-232
    • Jiang, Y.J.1    Teichert, A.E.2    Fong, F.3    Oda, Y.4    Bikle, D.D.5
  • 32
    • 84906790378 scopus 로고    scopus 로고
    • The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions
    • A.T. Slominski, T.K. Kim, W. Li, A.K. Yi, A. Postlethwaite, and R.C. Tuckey The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions J. Steroid Biochem. Mol. Biol. 144 2014 28 39
    • (2014) J. Steroid Biochem. Mol. Biol. , vol.144 , pp. 28-39
    • Slominski, A.T.1    Kim, T.K.2    Li, W.3    Yi, A.K.4    Postlethwaite, A.5    Tuckey, R.C.6
  • 35
    • 33745199177 scopus 로고    scopus 로고
    • An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2
    • A. Slominski, I. Semak, J. Wortsman, J. Zjawiony, W. Li, B. Zbytek, and R.C. Tuckey An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2 FEBS J. 273 2006 2891 2901
    • (2006) FEBS J. , vol.273 , pp. 2891-2901
    • Slominski, A.1    Semak, I.2    Wortsman, J.3    Zjawiony, J.4    Li, W.5    Zbytek, B.6    Tuckey, R.C.7
  • 36
    • 63849125216 scopus 로고    scopus 로고
    • Metabolism of vitamin D2 to 17,20,24-trihydroxyvitamin D2 by cytochrome p450scc (CYP11A1)
    • M.N. Nguyen, A. Slominski, W. Li, Y.R. Ng, and R.C. Tuckey Metabolism of vitamin D2 to 17,20,24-trihydroxyvitamin D2 by cytochrome p450scc (CYP11A1) Drug Metab. Dispos. 37 2009 761 767
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 761-767
    • Nguyen, M.N.1    Slominski, A.2    Li, W.3    Ng, Y.R.4    Tuckey, R.C.5
  • 40
    • 0344736703 scopus 로고    scopus 로고
    • A pathway for the metabolism of vitamin D3: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)
    • O. Guryev, R.A. Carvalho, S. Usanov, A. Gilep, and R.W. Estabrook A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1) Proc. Natl. Acad. Sci. U. S. A. 100 2003 14754 14759
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 14754-14759
    • Guryev, O.1    Carvalho, R.A.2    Usanov, S.3    Gilep, A.4    Estabrook, R.W.5
  • 43
    • 0029941924 scopus 로고    scopus 로고
    • ACTH receptor, CYP11A1CYP17 and CYP21A2 genes are expressed in skin
    • A. Slominski, G. Ermak, and M. Mihm ACTH receptor, CYP11A1CYP17 and CYP21A2 genes are expressed in skin J. Clin. Endocrinol. Metab. 81 1996 2746 2749
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 2746-2749
    • Slominski, A.1    Ermak, G.2    Mihm, M.3
  • 48
    • 67650102678 scopus 로고    scopus 로고
    • 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes
    • Z. Janjetovic, M.A. Zmijewski, R.C. Tuckey, D.A. DeLeon, M.N. Nguyen, L.M. Pfeffer, and A.T. Slominski 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes PLoS One 4 2009 e5988
    • (2009) PLoS One , vol.4 , pp. e5988
    • Janjetovic, Z.1    Zmijewski, M.A.2    Tuckey, R.C.3    Deleon, D.A.4    Nguyen, M.N.5    Pfeffer, L.M.6    Slominski, A.T.7
  • 49
    • 75749106644 scopus 로고    scopus 로고
    • 20,23-Dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes
    • Z. Janjetovic, R.C. Tuckey, M.N. Nguyen, E.M. Thorpe Jr.; and A.T. Slominski 20,23-Dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes J. Cell. Physiol. 223 2010 36 48
    • (2010) J. Cell. Physiol. , vol.223 , pp. 36-48
    • Janjetovic, Z.1    Tuckey, R.C.2    Nguyen, M.N.3    Thorpe, Jr.E.M.4    Slominski, A.T.5
  • 58
    • 0035650708 scopus 로고    scopus 로고
    • Alternative splicing of CRH-R1 receptors in human and mouse skin: Identification of new variants and their differential expression
    • A. Pisarchik, and A.T. Slominski Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression FASEB J. 15 2001 2754 2756
    • (2001) FASEB J. , vol.15 , pp. 2754-2756
    • Pisarchik, A.1    Slominski, A.T.2
  • 61
    • 83755163779 scopus 로고    scopus 로고
    • Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure
    • A. Hosni-Ahmed, J.D. Barnes, J. Wan, and T.S. Jones Thiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure PLoS One 6 2011 e29163
    • (2011) PLoS One , vol.6 , pp. e29163
    • Hosni-Ahmed, A.1    Barnes, J.D.2    Wan, J.3    Jones, T.S.4
  • 62
    • 17044395076 scopus 로고    scopus 로고
    • Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening
    • J. Duan, J. Duan, Z. Zhang, and T. Tong Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening Int. J. Biochem. Cell. Biol. 37 2005 1407 1420
    • (2005) Int. J. Biochem. Cell. Biol. , vol.37 , pp. 1407-1420
    • Duan, J.1    Duan, J.2    Zhang, Z.3    Tong, T.4
  • 64
    • 84874825677 scopus 로고    scopus 로고
    • Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2′-deoxyguanosine) in ex vivo human skin
    • T.W. Fischer, K. Kleszczynski, L.H. Hardkop, N. Kruse, and D. Zillikens Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2′-deoxyguanosine) in ex vivo human skin J. Pineal Res. 54 2013 303 312
    • (2013) J. Pineal Res. , vol.54 , pp. 303-312
    • Fischer, T.W.1    Kleszczynski, K.2    Hardkop, L.H.3    Kruse, N.4    Zillikens, D.5
  • 65
    • 84904733528 scopus 로고    scopus 로고
    • Luteolin modulates expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways in hepatic cells
    • T. Zhang, Y. Kimura, S. Jiang, K. Harada, Y. Yamashita, and H. Ashida Luteolin modulates expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways in hepatic cells Arch. Biochem. Biophys. 557 2014 36 46
    • (2014) Arch. Biochem. Biophys. , vol.557 , pp. 36-46
    • Zhang, T.1    Kimura, Y.2    Jiang, S.3    Harada, K.4    Yamashita, Y.5    Ashida, H.6
  • 68
    • 14044256602 scopus 로고    scopus 로고
    • Ultraviolet A and B affect human melanocytes and keratinocytes differently. A study of oxidative alterations and apoptosis
    • P. Larsson, E. Andersson, U. Johansson, K. Ollinger, and I. Rosdahl Ultraviolet A and B affect human melanocytes and keratinocytes differently. A study of oxidative alterations and apoptosis Exp. Dermatol. 14 2005 117 123
    • (2005) Exp. Dermatol. , vol.14 , pp. 117-123
    • Larsson, P.1    Andersson, E.2    Johansson, U.3    Ollinger, K.4    Rosdahl, I.5
  • 69
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    • Nguyen, P. Nioi, and C.B. Pickett The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress J. Biol. Chem. 284 2009 13291 13295
    • (2009) J. Biol. Chem. , vol.284 , pp. 13291-13295
    • Nguyen1    Nioi, P.2    Pickett, C.B.3
  • 70
    • 84868202074 scopus 로고    scopus 로고
    • Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability
    • D.H. Oh, D. Rigas, A. Cho, and J.Y. Chan Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability FEBS J. 279 2012 4121 4130
    • (2012) FEBS J. , vol.279 , pp. 4121-4130
    • Oh, D.H.1    Rigas, D.2    Cho, A.3    Chan, J.Y.4
  • 73
    • 33845706850 scopus 로고    scopus 로고
    • Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems
    • T.W. Fischer, T.W. Sweatman, I. Semak, R.M. Sayre, J. Wortsman, and A. Slominski Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems FASEB J. 20 2006 1564 1566
    • (2006) FASEB J. , vol.20 , pp. 1564-1566
    • Fischer, T.W.1    Sweatman, T.W.2    Semak, I.3    Sayre, R.M.4    Wortsman, J.5    Slominski, A.6
  • 74
    • 13244267262 scopus 로고    scopus 로고
    • The cutaneous serotoninergic/melatoninergic system: Securing a place under the sun
    • A. Slominski, J. Wortsman, and D.J. Tobin The cutaneous serotoninergic/melatoninergic system: securing a place under the sun FASEB J. 19 2005 176 194
    • (2005) FASEB J. , vol.19 , pp. 176-194
    • Slominski, A.1    Wortsman, J.2    Tobin, D.J.3
  • 75
    • 0027528673 scopus 로고
    • High levels of p53 protein in UV-irradiated normal human skin
    • P.A. Hall, P.H. McKee, H.D. Menage, R. Dover, and D.P. Lane High levels of p53 protein in UV-irradiated normal human skin Oncogene 8 1993 203 207
    • (1993) Oncogene , vol.8 , pp. 203-207
    • Hall, P.A.1    McKee, P.H.2    Menage, H.D.3    Dover, R.4    Lane, D.P.5
  • 77
    • 0033580776 scopus 로고    scopus 로고
    • Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro
    • M.D. Mediavilla, S. Cos, and E.J. Sanchez-Barcelo Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro Life Sci. 65 1999 415 420
    • (1999) Life Sci. , vol.65 , pp. 415-420
    • Mediavilla, M.D.1    Cos, S.2    Sanchez-Barcelo, E.J.3
  • 80
    • 83955164260 scopus 로고    scopus 로고
    • L-tyrosine and l-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions
    • A. Slominski, M.A. Zmijewski, and J. Pawelek l-tyrosine and l-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions Pigment Cell Melan. Res. 25 2012 14 27
    • (2012) Pigment Cell Melan. Res. , vol.25 , pp. 14-27
    • Slominski, A.1    Zmijewski, M.A.2    Pawelek, J.3
  • 81
    • 4644237315 scopus 로고    scopus 로고
    • Melanin pigmentation in mammalian skin and its hormonal regulation
    • A. Slominski, D.J. Tobin, S. Shibahara, and J. Wortsman Melanin pigmentation in mammalian skin and its hormonal regulation Physiol. Rev. 84 2004 1155 1228
    • (2004) Physiol. Rev. , vol.84 , pp. 1155-1228
    • Slominski, A.1    Tobin, D.J.2    Shibahara, S.3    Wortsman, J.4
  • 82
    • 49049087975 scopus 로고    scopus 로고
    • Melatonin as a major skin protectant: From free radical scavenging to DNA damage repair
    • T.W. Fischer, A. Slominski, M.A. Zmijewski, R.J. Reiter, and R. Paus Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair Exp. Dermatol. 17 2008 713 730
    • (2008) Exp. Dermatol. , vol.17 , pp. 713-730
    • Fischer, T.W.1    Slominski, A.2    Zmijewski, M.A.3    Reiter, R.J.4    Paus, R.5
  • 83
    • 77952526624 scopus 로고    scopus 로고
    • Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin
    • A.T. Slominski, M.A. Zmijewski, I. Semak, T. Sweatman, Z. Janjetovic, W. Li, J.K. Zjawiony, and R.C. Tuckey Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin PLoS One 4 2009 e4309
    • (2009) PLoS One , vol.4 , pp. e4309
    • Slominski, A.T.1    Zmijewski, M.A.2    Semak, I.3    Sweatman, T.4    Janjetovic, Z.5    Li, W.6    Zjawiony, J.K.7    Tuckey, R.C.8
  • 86
    • 84884202104 scopus 로고    scopus 로고
    • Genetic variation of the cutaneous HPA axis: An analysis of UVB-induced differential responses
    • C. Skobowiat, R. Nejati, L. Lu, R.W. Williams, and A.T. Slominski Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses Gene 530 2013 1 7
    • (2013) Gene , vol.530 , pp. 1-7
    • Skobowiat, C.1    Nejati, R.2    Lu, L.3    Williams, R.W.4    Slominski, A.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.