Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity

Steroids

Volumn 75, Issue 12, 2010, Pages 926-935

  Li, Wei ^a   Chen, Jianjun ^a   Janjetovic, Zorica ^a   Kim, Tae Kang ^a   Sweatman, Trevor ^a   Lu, Yan ^a   Zjawiony, Jordan ^b   Tuckey, Robert C ^c   Miller, Duane ^a   Slominski, Andrzej ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

20S Hydroxyvitamin D3; Antiproliferative activity; Chemical synthesis; Melanoma

Indexed keywords

17,20 HYDROCOLECALCIFEROL; 1ALPHA,20 HYDROCOLECALCIFEROL; 20,23 HYDROCOLECALCIFEROL; 20S HYDROXYVITAMIN D3; CALCITRIOL; COLECALCIFEROL DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 27B1; INVOLUCRIN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL PROLIFERATION; COLONY FORMING CELL; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; DRUG TRANSFORMATION; GENE EXPRESSION; HAMSTER; HUMAN; HUMAN CELL; KERATINOCYTE; MELANOMA CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; CALCIFEDIOL; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLECALCIFEROL; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CRICETINAE; HUMANS; KERATINOCYTES; MODELS, MOLECULAR; MOLECULAR CONFORMATION;

CRICETINAE;

EID: 77955927820     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2010.05.021     Document Type: Article

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