Punicalagin attenuated cerebral ischemia–reperfusion insult via inhibition of proinflammatory cytokines, up-regulation of Bcl-2, down-regulation of Bax, and caspase-3

Molecular and Cellular Biochemistry

Volumn 402, Issue 1-2, 2015, Pages 141-148

  Yaidikar, Lavanya ^a   Thakur, Santhrani ^a  

^a INSTITUTE OF PHARMACEUTICAL TECHNOLOGY   (India)

Author keywords

Anti apoptotic activity; Anti inflammatory action; Cerebral ischemia reperfusion injury; Neuroprotection; Punicalagin

Indexed keywords

CALCIUM; CASPASE 3; GLUTAMIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEUROPROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; PUNICALAGIN; TANNIN DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; BAX PROTEIN, RAT; CASP3 PROTEIN, RAT; CYTOKINE; TANNIN;

ADHESIVE REMOVAL TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN TISSUE; CALCIUM BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; EXCITOTOXICITY; FOREFOOT; GRIP STRENGTH; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION; WESTERN BLOTTING; ANIMAL; COMPLICATION; DRUG SCREENING; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; MUSCLE STRENGTH; SECRETION (PROCESS); WISTAR RAT;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CYTOKINES; DRUG EVALUATION, PRECLINICAL; HYDROLYZABLE TANNINS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION MEDIATORS; MALE; MUSCLE STRENGTH; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS, WISTAR; REPERFUSION INJURY; UP-REGULATION;

EID: 84925500452     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2321-y     Document Type: Article

References (39)

1. Elkind MS (2009) Outcomes after stroke: risk of recurrent ischemic stroke and other events. Am J Med 122(4):S7–S13
2. Park CK, Nehls DG, Graham DI, Teasdale GM, McCulloch J (1988) The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann Neurol 24(4):543–551
3. 2+ concentration in the hippocampal CA1 area during global ischemia and reperfusion in the rat: a possible cause of delayed neuronal death. Neuroscience 88(1):57–67
4. Peters O, Back T, Lindauer U, Busch C, Megow D, Dreier J, Dirnagl U (1998) Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 18(2):196–205
5. Lakhan SE, Kirchgessner A, Hofer M (2009) Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 7:97
6. Nakka VP, Gusain A, Mehta SL, Raghubir R (2008) Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol Neurobiol 37(1):7–38
7. Mehta SL, Manhas N, Raghubir R (2007) Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev 54(1):34–66
8. Szewka AJ, Prabhakaran S (2009) An update on acute ischemic stroke therapies. Compr Ther 35(2):72–80
9. Zhou XQ, Zeng XN, Kong H, Sun XL (2008) Neuroprotective effects of berberine on stroke models in vitro and in vivo. Neurosci Lett 447(1):31–36
10. Ning N, Dang X, Bai C, Zhang C, Wang K (2012) Panax notoginsenoside produces neuroprotective effects in rat model of acute spinal cord ischemia–reperfusion injury. J Ethnopharmacol 139(2):504–512
11. Ahmed MAE, El-Morsy EM, Ahmed AAE (2014) Pomegranate extract protects against cerebral ischemia/reperfusion injury and preserves brain DNA integrity in rats. Life Sci 110(2):61–69
12. Tyagi S, Singh A, Bharadwaj P, Sahu S, Yadav AP, Kori ML (2012) Punicalagins—a large polyphenol compounds found in pomegranates: a therapeutic review. Acad J Plant Sci 5(2):45–49
13. Yaidikar L, Thakur SR (2014) Neuroprotective effect of Punicalagin against cerebral ischemia reperfusion induces oxidative brain injury. J Stroke Cerebrovasc Dis 23(10):2869–2878. doi:10.1016/j.jstrokecerebrovasdis.2014.07.020
14. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84–91
15. Moran PM, Higgins LS, Cordel B, Moser PC (1995) Age related learning deficits in transgenic mice expressing 721 amino acid Isoforms of human beta amyloid precursor protein. Proc Natl Acad Sci USA 92(12):5341–5345
16. Schallert T, Upchurch M, Lobaugh N, Farrar SB, Spirduso WW, Gilliam P, Vaughn D, Wilcox RE (1982) Tactile extinction, distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage. Pharmacol Biochem Behav 16(3):455–462
17. Bouet V, Feret T, Toutain J, Divoux D, Boulouard M, Schumann-Bard P (2007) Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse. Exp Neurol 203(3):555–567
18. Lowry OH, Rosebrough NJ, Farr AL, Randal RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265–295
19. Bernt E, Bergmeyer HU (1965) L-glutamate UV assay with glutamate dehydrogenase and NAD. Methods of enzymatic analysis, 2nd edn. Academic Press, New York, pp 1704–1708
20. Lo EH, Dalkara T, Moskowitz MA (2003) Neurological diseases: mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4(5):399–414
21. Luo Y, Yang Y, Liu J, Li HW, Yang J, Sui X, Yuan X, Nie ZY, Liu YQ, Chen D, Lin SH, Wang YA (2014) Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats. Brain Res 1565:37–47
22. Khan MM, Ahmad A, Ishrat T, Khuwaja G, Shrivastawa P, Khan MB, Raza SS, Javed H, Vaibhav K, Khan A, Islam F (2009) Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res 1292:123–135
23. Vaibhav K, Shrivastava P, Khan A, Javed H, Tabassum R, Ahmed ME, Khan MB, Khan MM, Islam F, Ahmad A, Siddiqui S, Safhi MM, Islam F (2012) Azadirachta indica mitigates behavioral impairments, oxidative damage, histological alterations and apoptosis in focal cerebral ischemia–reperfusion model of rats. Neurol Sci 34(8):1321–1330. doi:10.1007/s10072-012-1238-z
24. Tabassum R, Vaibhav K, Shrivastava P, Khan A, Ahmed ME, Javed H, Islam F, Ahmad S, Siddiqui MS, Safhi MM, Islam F (2012) Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats. Neurol Sci 34(6):925–933
25. Brahma MK, Dohare P, Varma S, Rath SK, Garg P, Biswal PK, Chowdhury PD, Ray M (2009) The neuronal apoptotic cell death in global cerebral ischemia in gerbil: important role for sodium channel modulator. J Neurosci Res 87(6):1400–1411
26. Xuan A, Long D, Li J, Ji W, Hong L, Zhang M, Zhang W (2012) Neuroprotective effects of valproic acid following transient global ischemia in rats. Life Sci 90(11–12):463–468
27. Chen B, Lia WQ, Xu N, Xu H, Wen JY, Yu CA, Liu XY, Li CL, Zhao SM, Campbell W (2009) Adinopectin protects against cerebral ischemia reperfusion injury through anti-inflammatory action. Brain Res 1273:129–137
28. Khan M, Elango C, Ansari MA, Singh I, Singh AK (2007) Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem 102(2):365–377
29. Wang Q, Tang XN, Yenari MA (2007) The inflammatory response in stroke. J Neuroimmunol 184:53–68
30. Terao S, Yilmaz G, Stokes KY, Ishikawa M, Kawase T, Granger DN (2008) Inflammatory and injury responses to ischemic stroke in obese mice. Stroke 39:943–950
31. Kroemer G, Reed JC (2000) Mitochondrial control of cell death. Nat Med 6:513–519
32. Ferrer I (2006) Apoptosis: future targets for Neuroprotective strategies. Cerebrovasc Dis 21(2):9–20
33. Broughton BR, Reutens DC, Sobey CG (2009) Apoptotic mechanisms after cerebral ischemia. Stroke 40:e331–e339
34. Loor G, Kondapalli J, Iwase H, Chandel NS, Waypa GB, Guzy RD, Vanden-Hoek TL, Schumacker PT (2011) Mitochondrial oxidant stress triggers cell death in simulated ischemia–reperfusion. Biochim Biophys Acta 1813(7):1382–1394
35. Chaitanya GV, Babu PP (2008) Activation of calpain, cathepsin-b and Caspase-3 during transient focal cerebral ischemia in rat model. Neurochem Res 33(11):2178–2186
36. Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC et al (2002) Caspase activation and neuroprotection in Caspase-3 deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci USA 99:15188–15193
37. Okazaki T, Magaki T, Takeda M, Kajiwara Y, Hanaya R, Sugiyama K et al (2008) Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 expression and improves sensorimotor function following ischemia in rats. Neurosci Lett 430:109–114
38. Wang GH, Lan R, Zhen XD, Zhang W, Xiang J, Cai DF (2014) An-Gong-Niu-Huang Wan protects against cerebral ischemia induced apoptosis in rats: up-regulation of Bcl-2 and down-regulation of Bax and Caspase-3. J Ethnopharmacol 154:156–162
39. Okuno S, Saito A, Hayashi T, Chan PH (2004) The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal ischemia. J Neurosci 24:7879–7887