메뉴 건너뛰기




Volumn 34, Issue 6, 2013, Pages 925-933

Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats

Author keywords

Asiatic acid; Centella asiatica; Ischemia reperfusion; Neurobehavior; Oxidative stress

Indexed keywords

ALCOHOL; ASIATIC ACID; ASIATICOSIDE; CATALASE; CENTELLA ASIATICA EXTRACT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MADECASSIC ACID; MADECOSSIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84879072641     PISSN: 15901874     EISSN: 15903478     Source Type: Journal    
DOI: 10.1007/s10072-012-1163-1     Document Type: Article
Times cited : (71)

References (44)
  • 1
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • 10441299 10.1016/S0166-2236(99)01401-0 1:CAS:528:DyaK1MXlsVygtrk%3D
    • Dirnagl U, Iadecola C, Moskowitz AM (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391-397
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, A.M.3
  • 2
    • 29844458758 scopus 로고    scopus 로고
    • Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion
    • 16386242 10.1016/j.ejphar.2005.11.049 1:CAS:528:DC%2BD28XhsFeqsw%3D%3D
    • Collino M, Aragno M, Mastrocola R et al (2006) Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur J Pharmacol 530:70-80
    • (2006) Eur J Pharmacol , vol.530 , pp. 70-80
    • Collino, M.1    Aragno, M.2    Mastrocola, R.3
  • 3
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan PH (2004) Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 21:2-14
    • (2004) J Cereb Blood Flow Metab , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 4
    • 79961210488 scopus 로고    scopus 로고
    • Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion
    • 21472457 10.1007/s11064-011-0458-6 1:CAS:528:DC%2BC3MXktlyitr4%3D
    • Ahmad A, Khan MM, Hoda MN et al (2011) Quercetin protects against oxidative stress associated damages in a rat model of transient focal cerebral ischemia and reperfusion. Neurochem Res 36:1360-1371
    • (2011) Neurochem Res , vol.36 , pp. 1360-1371
    • Ahmad, A.1    Khan, M.M.2    Hoda, M.N.3
  • 5
    • 69449089391 scopus 로고    scopus 로고
    • Rutin protects the neural damage induced by transient focal ischemia in rats
    • 19631195 10.1016/j.brainres.2009.07.026 1:CAS:528:DC%2BD1MXhtV2kt7vK
    • Khan MM, Ahmad A, Ishrat T et al (2009) Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res 1292:123-135
    • (2009) Brain Res , vol.1292 , pp. 123-135
    • Khan, M.M.1    Ahmad, A.2    Ishrat, T.3
  • 6
    • 33846195008 scopus 로고    scopus 로고
    • Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia
    • 17201642 10.1089/jmf.2006.9.537 1:CAS:528:DC%2BD2sXht12rtg%3D%3D
    • Saleem S, Ahmad M, Ahmad AS et al (2006) Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia. J Med Food 9:537-544
    • (2006) J Med Food , vol.9 , pp. 537-544
    • Saleem, S.1    Ahmad, M.2    Ahmad, A.S.3
  • 7
    • 33745826332 scopus 로고    scopus 로고
    • Effect of saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats
    • 10.1089/jmf.2006.9.246
    • Saleem S, Ahmad M, Ahmad AS et al (2006) Effect of saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats. J Med Food 92:246-253
    • (2006) J Med Food , vol.92 , pp. 246-253
    • Saleem, S.1    Ahmad, M.2    Ahmad, A.S.3
  • 8
    • 0037212415 scopus 로고    scopus 로고
    • Protective effect of Nardostachys jatamansi in rat cerebral ischemia
    • 12479970 10.1016/S0091-3057(02)01030-4 1:CAS:528:DC%2BD38XptlGitLc%3D
    • Salim S, Ahmad M, Zafar KS, Ahmad AS, Islam F (2003) Protective effect of Nardostachys jatamansi in rat cerebral ischemia. Pharmacol Biochem Behav 74:481-486
    • (2003) Pharmacol Biochem Behav , vol.74 , pp. 481-486
    • Salim, S.1    Ahmad, M.2    Zafar, K.S.3    Ahmad, A.S.4    Islam, F.5
  • 9
    • 23744496980 scopus 로고
    • 13th edn. Chaukhamba Publications Vishwa Bharati Academy, New Delhi, India
    • Sharma PV (1992) Dravyaguna Vignana, 13th edn. Chaukhamba Publications Vishwa Bharati Academy, New Delhi, India
    • (1992) Dravyaguna Vignana
    • Sharma, P.V.1
  • 10
    • 35348861285 scopus 로고    scopus 로고
    • Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats
    • 17600859 10.1002/ptr.2208 1:CAS:528:DC%2BD2sXhtlelsb3N
    • Flora SJ, Gupta R (2007) Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats. Phytother Res 21:980-988
    • (2007) Phytother Res , vol.21 , pp. 980-988
    • Flora, S.J.1    Gupta, R.2
  • 11
    • 70349436982 scopus 로고    scopus 로고
    • Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts
    • George M, Joseph L, Ramaswamy (2009) Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts. Afr J Tradit Complem Altern Med 6:554-559
    • (2009) Afr J Tradit Complem Altern Med , vol.6 , pp. 554-559
    • George, M.1    Joseph, L.2    Ramaswamy3
  • 12
    • 79952152598 scopus 로고    scopus 로고
    • Triterpene composition and bioactivities of Centella asiatica
    • 21278681 10.3390/molecules16021310 1:CAS:528:DC%2BC3MXhvFans7w%3D
    • Hashim P, Sidek H, Helan MH, Sabery A, Palanisamy UD, Ilham M (2011) Triterpene composition and bioactivities of Centella asiatica. Molecules 16:1310-1322
    • (2011) Molecules , vol.16 , pp. 1310-1322
    • Hashim, P.1    Sidek, H.2    Helan, M.H.3    Sabery, A.4    Palanisamy, U.D.5    Ilham, M.6
  • 13
    • 58149506251 scopus 로고    scopus 로고
    • Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model
    • 19048607 10.1002/ptr.2405
    • Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B, Porter JW, Young KA, Manyam BV (2009) Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model. Phytother Res 23:14-19
    • (2009) Phytother Res , vol.23 , pp. 14-19
    • Dhanasekaran, M.1    Holcomb, L.A.2    Hitt, A.R.3    Tharakan, B.4    Porter, J.W.5    Young, K.A.6    Manyam, B.V.7
  • 14
    • 76749084818 scopus 로고    scopus 로고
    • Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced Parkinsonism in aged Sprague-Dawley rats
    • 20118623 10.2131/jts.35.41 1:CAS:528:DC%2BC3cXjt1Glu70%3D
    • Haleagrahara N, Ponnusanny K (2010) Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced Parkinsonism in aged Sprague-Dawley rats. J Toxicol Sci 35:41-47
    • (2010) J Toxicol Sci , vol.35 , pp. 41-47
    • Haleagrahara, N.1    Ponnusanny, K.2
  • 15
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
    • 3715945 10.1161/01.STR.17.3.472 1:STN:280:DyaL283js1Gktw%3D%3D
    • Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.6
  • 16
    • 34147152673 scopus 로고    scopus 로고
    • Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus
    • 17376411 10.1016/j.brainres.2007.01.143 1:CAS:528:DC%2BD2sXksVOqt7g%3D
    • Yousuf S, Atif F, Ahmad M, Hoda MN, Khan MB, Ishrat T, Islam F (2007) Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus. Brain Res 1147:218-225
    • (2007) Brain Res , vol.1147 , pp. 218-225
    • Yousuf, S.1    Atif, F.2    Ahmad, M.3    Hoda, M.N.4    Khan, M.B.5    Ishrat, T.6    Islam, F.7
  • 17
    • 3042673221 scopus 로고    scopus 로고
    • Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behaviour
    • 15145301 10.1016/j.yebeh.2004.01.005
    • Ali A, Ahmad FJ, Pillai KK, Vohora D (2004) Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behaviour. Epilepsy Behav 5:322-328
    • (2004) Epilepsy Behav , vol.5 , pp. 322-328
    • Ali, A.1    Ahmad, F.J.2    Pillai, K.K.3    Vohora, D.4
  • 18
    • 0033647163 scopus 로고    scopus 로고
    • Mouse models of alpha-synucleinopathy and Lewy pathology
    • 11113617 10.1016/S0531-5565(00)00181-9 1:CAS:528:DC%2BD3cXoslGgu7c%3D
    • Sommer B, Barbieri S, Hofele K et al (2000) Mouse models of alpha-synucleinopathy and Lewy pathology. Exp Gerontol 35:1389-1403
    • (2000) Exp Gerontol , vol.35 , pp. 1389-1403
    • Sommer, B.1    Barbieri, S.2    Hofele, K.3
  • 19
    • 0023732415 scopus 로고
    • (S)-Emopamil, a novel calcium channel blocker and serotonin S2 antagonist, markedly reduces infarct size following middle cerebral artery occlusion in rat
    • 3185899 10.1212/WNL.38.11.1667 1:STN:280:DyaL1M%2FktVGnsg%3D%3D
    • Nakayama H, Ginsberg MD, Dietrich WD (1988) (S)-Emopamil, a novel calcium channel blocker and serotonin S2 antagonist, markedly reduces infarct size following middle cerebral artery occlusion in rat. Neurology 38:1667-1673
    • (1988) Neurology , vol.38 , pp. 1667-1673
    • Nakayama, H.1    Ginsberg, M.D.2    Dietrich, W.D.3
  • 20
    • 0036961980 scopus 로고    scopus 로고
    • Selenium induced alteration on lipids, lipid peroxidation, and thiol group in circadian rhythm centers of rat
    • 10.1385/BTER:90:1-3:203
    • Islam F, Zia S, Sayeed I, Zafar KS, Ahmad AS (2002) Selenium induced alteration on lipids, lipid peroxidation, and thiol group in circadian rhythm centers of rat. Biol Trace Elem Res 90:1-12
    • (2002) Biol Trace Elem Res , vol.90 , pp. 1-12
    • Islam, F.1    Zia, S.2    Sayeed, I.3    Zafar, K.S.4    Ahmad, A.S.5
  • 21
    • 0016151122 scopus 로고
    • Bromobenzene induced liver necrosis: Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic intermediate
    • 10.1159/000136485
    • Jollow DJ, Mitchell JR, Zampaghone N, Gillete JR (1974) Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic intermediate. Pharmacology 11:161-169
    • (1974) Pharmacology , vol.11 , pp. 161-169
    • Jollow, D.J.1    Mitchell, J.R.2    Zampaghone, N.3    Gillete, J.R.4
  • 23
    • 0021752183 scopus 로고
    • Differential distribution of glutathione and glutathione related enzymes in rabbit kidneys: Possible implication in analgesic neuropathy
    • 6149017 1:CAS:528:DyaL2cXmt1Oqsro%3D
    • Mohandas J, Marshall JJ, Duggin GG, Horvath JS, Tiller D (1984) Differential distribution of glutathione and glutathione related enzymes in rabbit kidneys: possible implication in analgesic neuropathy. Cancer Res 44:5086-5091
    • (1984) Cancer Res , vol.44 , pp. 5086-5091
    • Mohandas, J.1    Marshall, J.J.2    Duggin, G.G.3    Horvath, J.S.4    Tiller, D.5
  • 24
    • 0016275313 scopus 로고
    • Glutathione S-transferase: The first enzymatic step in mercapturic acid formation
    • 4436300 1:CAS:528:DyaE2MXltlahtg%3D%3D
    • Habig WH, Pabst M, Jakoby WB (1974) Glutathione S-transferase: the first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.2    Jakoby, W.B.3
  • 25
    • 0034038502 scopus 로고    scopus 로고
    • Effect of DL-alpha- lipidic acid on peripheral nerve conduction, blood flow, energy metabolism and oxidative stress in experimental diabetic neuropathy
    • 10866054 10.2337/diabetes.49.6.1006 1:CAS:528:DC%2BD3cXjvFylu70%3D
    • Stevens MJ, Obrosova I, Cao X, Huysen CV, Green DA (2000) Effect of DL-alpha- lipidic acid on peripheral nerve conduction, blood flow, energy metabolism and oxidative stress in experimental diabetic neuropathy. Diabetes 49:1006-1015
    • (2000) Diabetes , vol.49 , pp. 1006-1015
    • Stevens, M.J.1    Obrosova, I.2    Cao, X.3    Huysen, C.V.4    Green, D.A.5
  • 26
    • 71849104860 scopus 로고
    • Protein measurement with the folin phenol reagent
    • 14907713 1:CAS:528:DyaG38XhsVyrsw%3D%3D
    • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosenbrough, N.J.2    Farr, A.L.3    Randall, R.J.4
  • 27
    • 79251649397 scopus 로고    scopus 로고
    • Cerebroprotective effect of Ocimum gratissimum against focal ischemia and reperfusion-induced cerebral injury
    • 20969537 10.3109/13880209.2010.506489
    • Bora KS, Shri R, Monga J (2011) Cerebroprotective effect of Ocimum gratissimum against focal ischemia and reperfusion-induced cerebral injury. Pharm Biol 49:175-181
    • (2011) Pharm Biol , vol.49 , pp. 175-181
    • Bora, K.S.1    Shri, R.2    Monga, J.3
  • 28
    • 0034014316 scopus 로고    scopus 로고
    • Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain
    • 10783150 1:CAS:528:DC%2BD3cXjtVejurg%3D
    • Cui J, Holmes EH, Greene TG, Liu PK (2000) Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain. FASEB J 14:955-967
    • (2000) FASEB J , vol.14 , pp. 955-967
    • Cui, J.1    Holmes, E.H.2    Greene, T.G.3    Liu, P.K.4
  • 29
    • 46349090692 scopus 로고    scopus 로고
    • Mechanisms of ischemic brain damage
    • 18308346 10.1016/j.neuropharm.2008.01.005 1:CAS:528:DC%2BD1cXhtVSit77L
    • Doyle KP, Simon RP, Stenzel-Poore MP (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55:310-318
    • (2008) Neuropharmacology , vol.55 , pp. 310-318
    • Doyle, K.P.1    Simon, R.P.2    Stenzel-Poore, M.P.3
  • 30
    • 71349087001 scopus 로고    scopus 로고
    • Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats
    • 10.1016/j.cbi.2009.10.003 1:CAS:528:DC%2BD1MXhsFGgs7fL
    • Khan MM, Ishrat T, Ahmad A et al (2010) Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats. Chemi-Biol Interact 183:255-263
    • (2010) Chemi-Biol Interact , vol.183 , pp. 255-263
    • Khan, M.M.1    Ishrat, T.2    Ahmad, A.3
  • 31
    • 0036192440 scopus 로고    scopus 로고
    • Ultrastructural changes of neuronal mitochondria after transient and permanent cerebral ischemia
    • 11872909 10.1161/hs0302.104541
    • Solenski NJ, diPierro CG, Trimmer PA, Kwan AL, Gregory A, Helms GA (2002) Ultrastructural changes of neuronal mitochondria after transient and permanent cerebral ischemia. Stroke 33:816-824
    • (2002) Stroke , vol.33 , pp. 816-824
    • Solenski, N.J.1    Dipierro, C.G.2    Trimmer, P.A.3    Kwan, A.L.4    Gregory, A.5    Helms, G.A.6
  • 32
    • 0021742029 scopus 로고
    • Limitations of tetrazolium salts in delineating infarcted brain
    • 6084391 10.1007/BF00690469 1:STN:280:DyaL2M7hvVWltg%3D%3D
    • Liszczak TM, Hedley-Whyte ET, Adams JF et al (1984) Limitations of tetrazolium salts in delineating infarcted brain. Acta Neuropathol 65:150-157
    • (1984) Acta Neuropathol , vol.65 , pp. 150-157
    • Liszczak, T.M.1    Hedley-Whyte, E.T.2    Adams, J.F.3
  • 33
    • 63449119215 scopus 로고    scopus 로고
    • Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats
    • 19272172 10.1186/1423-0127-16-9
    • Chang Y, Hsieh CY, Peng ZA, Yen TL, Hsiao G, Chou DS, Chen CM, Sheu JR (2009) Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats. J Biomed Sci 16:9
    • (2009) J Biomed Sci , vol.16 , pp. 9
    • Chang, Y.1    Hsieh, C.Y.2    Peng, Z.A.3    Yen, T.L.4    Hsiao, G.5    Chou, D.S.6    Chen, C.M.7    Sheu, J.R.8
  • 34
    • 0032924640 scopus 로고    scopus 로고
    • Oxidative stress in brain ischemia
    • 9989455 10.1111/j.1750-3639.1999.tb00214.x 1:CAS:528:DyaK1MXht1Cmsb8%3D
    • Love S (1999) Oxidative stress in brain ischemia. Brain Pathol 9:119-131
    • (1999) Brain Pathol , vol.9 , pp. 119-131
    • Love, S.1
  • 35
    • 0035812642 scopus 로고    scopus 로고
    • Effect of melatonin on ischemia reperfusion injury induced by middle cerebral artery occlusion in rats
    • 11675035 10.1016/S0014-2999(01)01253-5 1:CAS:528:DC%2BD3MXnslajsrc%3D
    • Sinha K, Degaonkar MN, Jagannathan NR, Gupta YK (2001) Effect of melatonin on ischemia reperfusion injury induced by middle cerebral artery occlusion in rats. Eur J Pharmacol 428:185-192
    • (2001) Eur J Pharmacol , vol.428 , pp. 185-192
    • Sinha, K.1    Degaonkar, M.N.2    Jagannathan, N.R.3    Gupta, Y.K.4
  • 36
    • 0033971069 scopus 로고    scopus 로고
    • Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic toxicity and peroxynitrite generation
    • 10650149 10.1016/S0006-8993(99)02249-0 1:CAS:528:DC%2BD3cXmtVOitQ%3D%3D
    • Imam SZ, Ali SF (2000) Selenium, an antioxidant, attenuates methamphetamine-induced dopaminergic toxicity and peroxynitrite generation. Brain Res 855:186-191
    • (2000) Brain Res , vol.855 , pp. 186-191
    • Imam, S.Z.1    Ali, S.F.2
  • 37
    • 39149136847 scopus 로고    scopus 로고
    • Reactive oxygen species mediate ERK activation through different RAF-1-dependent signaling pathways following cerebral ischemia
    • 18243549 10.1016/j.neulet.2007.11.073 1:CAS:528:DC%2BD1cXitVegurw%3D
    • Wu HW, Li HF, Wu XY, Zhao J, Guo J (2008) Reactive oxygen species mediate ERK activation through different RAF-1-dependent signaling pathways following cerebral ischemia. Neurosci Lett 432:83-87
    • (2008) Neurosci Lett , vol.432 , pp. 83-87
    • Wu, H.W.1    Li, H.F.2    Wu, X.Y.3    Zhao, J.4    Guo, J.5
  • 38
    • 0030967073 scopus 로고    scopus 로고
    • Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes
    • 9164836 1:CAS:528:DyaK2sXjsFCjurk%3D
    • Baez S, Segura-Aguilar J, Widersten M, Johansson AS, Mannervik B (1997) Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem J 324:25-28
    • (1997) Biochem J , vol.324 , pp. 25-28
    • Baez, S.1    Segura-Aguilar, J.2    Widersten, M.3    Johansson, A.S.4    Mannervik, B.5
  • 39
    • 79957925593 scopus 로고    scopus 로고
    • Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro
    • 21554870 10.1016/j.ejphar.2011.04.052 1:CAS:528:DC%2BC3MXntV2htbo%3D
    • Cheng Z, He W, Zhou X, Lv Q, Xu X, Yang S, Zhao C, Guo L (2011) Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro. Eur J Pharmacol 664:20-28
    • (2011) Eur J Pharmacol , vol.664 , pp. 20-28
    • Cheng, Z.1    He, W.2    Zhou, X.3    Lv, Q.4    Xu, X.5    Yang, S.6    Zhao, C.7    Guo, L.8
  • 40
    • 34547801778 scopus 로고    scopus 로고
    • Neuroprotective evaluation of standardized extract of Centella asiatica in monosodium glutamate treated rats
    • 17569283 1:CAS:528:DC%2BD2sXmtl2ntrc%3D
    • Ramanathan M, Sivakumar S, Anandvijayakumar PR, Saravanababu C, Pandian PR (2007) Neuroprotective evaluation of standardized extract of Centella asiatica in monosodium glutamate treated rats. Indian J Exp Biol 45:425-435
    • (2007) Indian J Exp Biol , vol.45 , pp. 425-435
    • Ramanathan, M.1    Sivakumar, S.2    Anandvijayakumar, P.R.3    Saravanababu, C.4    Pandian, P.R.5
  • 41
    • 84862273441 scopus 로고    scopus 로고
    • Centella asiatica (L.) Urban; From traditional medicine to modern medicine with neuroprotective potential
    • doi: 10.1155/2012/946259
    • Orhan IE (2012) Centella asiatica (L.) Urban; from traditional medicine to modern medicine with neuroprotective potential. Evid Based Complement Altern Med 2012:946259. doi: 10.1155/2012/946259
    • (2012) Evid Based Complement Altern Med , pp. 946259
    • Orhan, I.E.1
  • 43
    • 80054860012 scopus 로고    scopus 로고
    • Asiaticoside: Attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax
    • 22001429 10.1016/j.pbb.2011.09.014 1:CAS:528:DC%2BC3MXhs1Gjsr3P
    • Xu CL, Wang QZ, Sun LM, Li XM, Deng JM, Li LF, Zhang J, Xu R, Ma SP (2012) Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax. Pharmacol Biochem Behav 100:413-418
    • (2012) Pharmacol Biochem Behav , vol.100 , pp. 413-418
    • Xu, C.L.1    Wang, Q.Z.2    Sun, L.M.3    Li, X.M.4    Deng, J.M.5    Li, L.F.6    Zhang, J.7    Xu, R.8    Ma, S.P.9
  • 44
    • 25844474130 scopus 로고    scopus 로고
    • Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in vitro
    • 16105244 10.1211/jpp.57.9.0018 1:CAS:528:DC%2BD2MXhtVKntrrM
    • Soumyanath A, Zhong YP, Gold SA, Yu X, Koop DR, Bourdette D, Gold BG (2005) Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in vitro. J Pharm Pharmacol 57:1221-1229
    • (2005) J Pharm Pharmacol , vol.57 , pp. 1221-1229
    • Soumyanath, A.1    Zhong, Y.P.2    Gold, S.A.3    Yu, X.4    Koop, D.R.5    Bourdette, D.6    Gold, B.G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.