Hyaluronan suppresses mechanical stress-induced expression of catabolic enzymes by human chondrocytes via inhibition of IL-1β production and subsequent NF-κB activation

Inflammation Research

Volumn 64, Issue 3-4, 2015, Pages 243-252

  Ozawa, Masatsugu ^a   Nishida, Keiichiro ^a   Yoshida, Aki ^a   Saito, Taichi ^b   Harada, Ryozo ^a   Machida, Takahiro ^a   Ozaki, Toshifumi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Ako Central Hospital   (Japan)

Author keywords

Aggrecanase; Chondrocyte; Hyaluronan; Mechanical stress; NF B; RUNX 2

Indexed keywords

AGGRECANASE 1; AGGRECANASE 2; COLLAGENASE 3; DISINTEGRIN; HYALURONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; TRANSCRIPTION FACTOR RUNX2; ADAM PROTEIN; ADAMTS5 PROTEIN, HUMAN; AGGRECANASE-1; PROCOLLAGEN N PROTEINASE; RUNX2 PROTEIN, HUMAN;

ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INCUBATION TIME; MECHANICAL STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUPERNATANT; TENSILE STRENGTH; WESTERN BLOTTING; ADOLESCENT; ADULT; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; IN VITRO STUDY; METABOLISM;

ADAM PROTEINS; ADOLESCENT; ADULT; CELLS, CULTURED; CHONDROCYTES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DISINTEGRINS; HUMANS; HYALURONIC ACID; IN VITRO TECHNIQUES; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 13; NF-KAPPA B; PROCOLLAGEN N-ENDOPEPTIDASE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 84925497184     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-015-0804-2     Document Type: Article

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