Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 35, 2009, Pages 14972-14977

  Yount, Nannette Y ^a,b   Kupferwasser, Deborah ^a,b   Spisni, Alberto ^c   Dutz, Stephen M ^d   Ramjan, Zachary H ^d   Sharma, Shantanu ^d   Waring, Alan J ^e   Yeaman, Michael R ^a,b,e  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b St John's Cardiovascular Research Center   (United States)

^c UNIVERSITY OF PARMA   (Italy)

^d CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Channel; Defensin; Host defense; Toxin

Indexed keywords

CROTAMINE; PEPTIDE HBD 2; PHOSPHATIDYLSERINE; POLYPEPTIDE ANTIBIOTIC AGENT; POTASSIUM CHANNEL KV1.2; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CELL MEMBRANE POTENTIAL; CELL SPECIFICITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG PROTEIN BINDING; ESCHERICHIA COLI; EUKARYOTIC CELL; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; NONHUMAN; PH MEASUREMENT; PHYLOGENY; PRIORITY JOURNAL; PROKARYOTIC CELL; PROTEIN PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; TARGET CELL; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BETA-DEFENSINS; BIOPHYSICAL PHENOMENA; CELLS, CULTURED; CROTALID VENOMS; CROTALUS; ESCHERICHIA COLI; HUMANS; MICROBIAL VIABILITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA; PROKARYOTA;

EID: 70349281510     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904465106     Document Type: Article

References (44)

1. Yeaman MR, Yount NY (2003) Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev 55:27-55. (Pubitemid 36268398)
2. Yeaman MR, Yount NY (2007) Unifying themes in host defence effector polypeptides. Nat Rev 5:727-740.
3. Yount NY, Yeaman MR (2004) Multidimensional signatures in antimicrobial peptides. Proc Natl Acad Sci USA 101:7363-7368.
4. Nicastro G, et al. (2003) Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom. Eur J Biochem 270:1969-1979. (Pubitemid 36560818)
5. Mancin AC, et al. (1998) The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: A biochemical and pharmacological study. Toxicon 36:1927-1937.
6. Fry BG, et al. (2006) Early evolution of the venom system in lizards and snakes. Nature 439:584-588. (Pubitemid 43185381)
7. Radis-Baptista G, et al. (2004) Identification of crotasin, a crotamine-related gene of Crotalus durissus terrificus. Toxicon 43:751-759. (Pubitemid 38992521)
8. Baxter DF, et al. (2002)Anovel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels. J Biomol Screen 7:79-85.
9. Dorn A, et al. (2005) Evaluation of a high-throughput fluorescence assay method for HERG potassium channel inhibition. J Biomol Screen 10:339-347. (Pubitemid 40800562)
10. Slack M, Kirchhoff C, Moller C, Winkler D, Netzer R (2006) Identification of novel Kv1.3 blockers using a fluorescent cell-based ion channel assay. J Biomol Screen 11:57-64. (Pubitemid 43255782)
11. Andres MT, Viejo-Diaz M, Fierro JF (2008) Human lactoferrin induces apoptosis-like cell death in Candida albicans: Critical role of K+ channel-mediated K+ efflux. Antimicrob Agents Chemother 52:4081-4088.
12. Froy O, Gurevitz M (2004) Arthropod defensins illuminate the divergence of scorpion neurotoxins. J Pept Sci 10:714-718. (Pubitemid 40012313)
13. Ren D, et al. (2001) A prokaryotic voltage-gated sodium channel. Science 294:2372-2375.
14. Alam A, Jiang Y (2009) High-resolution structure of the open NaK channel. Nat Struct Mol Biol 16:30-34.
15. Gordienko DV, Tsukahara H (1994) Tetrodotoxin-blockable depolarization-activated Na+ currents in a cultured endothelial cell line derived from rat interlobar arter and human umbilical vein. Pflugers Arch 428:91-93.
16. Walsh KB, Wolf MB, Fan J (1998) Voltage-gated sodium channels in cardiac microvascular endothelial cells. Am J Physiol 274:H506-H512. (Pubitemid 28102982)
17. Lewis RJ, Garcia ML (2003) Therapeutic potential of venom peptides. Nat Rev Drug Dis 2:790-802.
18. Rogachevskii IV, et al. (2000) The defensin receptor: A possible mechanism responsible for reduced excitability of the neuronal sensory membrane. Dokl Biol Sci 375:595-598.
19. Kushmerick C, de Souza Castro M, Santos Cruz J, Bloch C Jr, Beirao PS (1998) Functional and structural features of gamma-zeathionins, a new class of sodium channel blockers. FEBS Lett 440:302-306. (Pubitemid 29052303)
20. Gordon YJ, Romanowski EG, McDermott AM (2005)A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr Eye Res 30:505-515. (Pubitemid 41113552)
21. Zasloff M (2002) Antimicrobial peptides of multicellular organisms. Nature 415:389-395.
22. Ganz T, Oren A, Lehrer RI (1992) Defensins: Microbicidal and cytotoxic peptides of mammalian host defense cells. Med Microbiol Immunol 181:99-105.
23. Yu L, et al. (2005) Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex. Biochemistry 44:15834-15841. (Pubitemid 41746914)
24. Zachariae U, et al. (2008) The molecular mechanism of toxin-induced conformational changes in a potassium channel: Relation to C-type inactivation. Structure 16:747-754. (Pubitemid 351615012)
25. Jouirou B, et al. (2004) Cobatoxin 1 from Centruroides noxius scorpion venom: Chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels. Biochem J 377:37-49. (Pubitemid 38114430)
26. Zhu S, Bosmans F, Tytgat J (2004) Adaptive evolution of scorpion sodium channel toxins. J Mol Evol 58:145-153. (Pubitemid 38183965)
27. Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R (2001) Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature 414:43-48. (Pubitemid 33041616)
28. Chang CC, Tseng KH (1978) Effect of crotamine, a toxin of South American rattlesnake venom, on the sodium channel of murine skeletal muscle. Br J Pharmacol 63:551-559.
29. Rizzi CT, et al. (2007) Crotamine inhibits preferentially fast-twitching muscles but is inactive on sodium channels. Toxicon 50:553-562.
30. Filler SG, Swerdloff JN, Hobbs C, Luckett PM (1995) Penetration and damage of endothelial cells by Candida albicans. Infect Immun 63:976-983.
31. Tang YQ, Yeaman MR, Selsted ME (2002) Antimicrobial peptides fromhumanplatelets. Infect Immun 70:6524-6533.
32. Tang YQ, et al. (1999) A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science 286:498-502.
33. Good NE, et al. (1966) Hydrogen ion buffers for biological research. Biochemistry 5:467-477.
34. Shindyalov IN, Bourne PE (1998) Protein structure alignment by incremental combinatorial extension (CE) of the optimal path. Protein Eng 11:739-747.
35. Higgins DG, Sharp PM (1988) CLUSTAL: A package for performing multiple sequence alignment on a microcomputer. Gene 73:237-244.
36. Saitou N, Nei M (1987) The neighbor-joining method:Anewmethod for reconstructing phylogenetic trees. Mol Biol Evol 4:406-425.
37. Kelley LA, MacCallum RM, Sternberg MJ (2000) Enhanced genome annotation using structural profiles in the program 3D-PSSM. J Mol Biol 299:499-520.
38. Konagurthu AS, Whisstock JC, Stuckey PJ, Lesk AM (2006) MUSTANG: A multiple structural alignment algorithm. Proteins 64:559-574. (Pubitemid 44100724)
39. Krieger E, Koraimann G, Vriend G (2002) Increasing the precision of comparative models with YASARA NOVA - a self-parameterizing force field. Proteins 47:393-402. (Pubitemid 34438688)
40. Phillips JC, et al. (2005) Scalable molecular dynamics with NAMD. J Comput Chem 26:1781-1802.
41. Gray JJ, et al. (2003) Protein-protein docking predictions for the CAPRI experiment. Proteins 52:118-122.
42. Koradi R, Billeter M, Wuthrich K (1996) MOLMOL: A program for display and analysis of macromolecular structures. J Mol Graph 14:51-55, 29-32. (Pubitemid 26152976)
43. Pettersen EF, et al. (2004) UCSF Chimera - a visualization system for exploratory research and analysis. J Comput Chem 25:1605-1612.
44. Humphrey W, Dalke A, Schulten K (1996) VMD: Visual molecular dynamics. J Mol Graph 14:33-38, 27-28.