Micelle-assisted combination therapies for effective glioblastoma treatment: An in-vitro assessment

Anti-Cancer Drugs

Volumn 26, Issue 3, 2015, Pages 312-322

  Mohanty, Anjan Kumar ^a   Mohanta, Guru Prasad ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Apoptosis; cell toxicity; cellular uptake; curcumin; glioblastoma; rapamycin

Indexed keywords

CURCUMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROGOL DERIVATIVE; METHOXY POLY(ETHYLENE GLYCOL-CO-EPSILON-CAPROLACTONE); MICELLE; POLYESTER; PTGS2 PROTEIN, HUMAN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG POTENTIATION; FEMALE; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE DEPOLARIZATION; MICELLE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL LINE, TUMOR; CURCUMIN; CYCLOOXYGENASE 2; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; GLIOBLASTOMA; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICELLES; NF-KAPPA B; POLYESTERS; POLYETHYLENE GLYCOLS; SIROLIMUS;

EID: 84925484819     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000186     Document Type: Article

References (36)

1. Burton EC, Prados MD. Malignant gliomas. Curr Treat Options Oncol 2000; 1:459-468.
2. Adamson C, Kanu OO, Mehta AI, Di C, Lin N, Mattox AK, Bigner DD. Glioblastoma multiforme: a review of where we have been and where we are going. Expert Opin Investig Drugs 2009; 18:1061-1083.
3. Mischel PS, Cloughesy TF. Targeted molecular therapy of GBM. Brain Pathol 2003; 13:52-61.
4. Zhu Z, Zhong S, Shen Z. Targeting the inflammatory pathways to enhance chemotherapy of cancer. Cancer Biol Ther 2011; 12:95-105.
5. Raychaudhuri B, Han Y, Lu T, Vogelbaum MA. Aberrant constitutive activation of nuclear factor kappaB in glioblastoma multiforme drives invasive phenotype. J Neurooncol 2007; 85:39-47.
6. Brown RE, Law A. Morphoproteomic demonstration of constitutive nuclear factor-kappaB activation in glioblastoma multiforme with genomic correlates and therapeutic implications. Ann Clin Lab Sci 2006; 36:421-426.
7. Lim TH, Fujikane R, Sano S, Sakagami R, Nakatsu Y, Tsuzuki T, et al. Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA. DNA Repair (Amst) 2012; 11:259-266.
8. Woo MS, Jung SH, Kim SY, Hyun JW, Ko KH, Kim WK, Kim HS. Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. Biochem Biophys Res Commun 2005; 335:1017-1025.
9. Muthukkumar S, Ramesh TM, Bondada S. Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells. Transplantation 1995; 60:264-270.
10. Acharya S, Dilnawaz F, Sahoo SK. Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy. Biomaterials 2009; 30:5737-5750.
11. Houchens DP, Ovejera AA, Riblet SM, Slagel DE. Human brain tumor xenografts in nude mice as a chemotherapy model. Eur J Cancer Clin Oncol 1983; 19:799-805.
12. Aryal S, Hu CM, Zhang L. Combinatorial drug conjugation enables nanoparticle dual-drug delivery. Small 2010; 6:1442-1448.
13. Sahoo SK, Labhasetwar V. Nanotech approaches to drug delivery and imaging. Drug Discov Today 2003; 8:1112-1120.
14. Croy SR, Kwon GS. Polymeric micelles for drug delivery. Curr Pharm Des 2006; 12:4669-4684.
15. Hu CM, Aryal S, Zhang L. Nanoparticle-assisted combination therapies for effective cancer treatment. Ther Deliv 2010; 1:323-334.
16. Mohanty AK, Dilnawaz F, Mohanty C, Sahoo SK. Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy. Drug Deliv 2010; 17:330-342.
17. Mohanty AK, Mohanta GP. Dual anticancer drug loaded methoxy poly (ethylene glycol)-poly (?-caprolactone) block copolymeric micelles as novel drug carriers. Int J Pharm Pharm Sci 2014; 6:328-332.
18. Sen GS, Mohanty S, Hossain DM, Bhattacharyya S, Banerjee S, Chakraborty J, et al. Curcumin enhances the efficacy of chemotherapy by tailoring p65NF?B-p300 cross-talk in favor of p53-p300 in breast cancer. J Biol Chem 2011; 286:42232-42247.
19. Crowley-Weber CL, Dvorakova K, Crowley C, Bernstein H, Bernstein C, Garewal H, Payne CM. Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. Chem Biol Interact 2003; 145:53-66.
20. Paramasivam A, Sambantham S, Shabnam J, Raghunandhakumar S, Anandan B, Rajiv R, et al. Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with downregulation of XIAP. Toxicol Lett 2012; 213:151-159.
21. Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 2010; 70:440-446.
22. Mohanty C, Acharya S, Mohanty AK, Dilnawaz F, Sahoo SK. Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy. Nanomedicine (Lond) 2010; 5:433-449.
23. Olichon A, Baricault L, Gas N, Guillou E, Valette A, Belenguer P, Lenaers G. Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis. J Biol Chem 2003; 278:7743-7746.
24. Agrawal DK, Mishra PK. Curcumin and its analogues: potential anticancer agents. Med Res Rev 2010; 30:818-860.
25. Misra R, Sahoo SK. Coformulation of doxorubicin and curcumin in poly(D, L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. Mol Pharm 2011; 8:852-866.
26. Kreuter J, Gelperina S. Use of nanoparticles for cerebral cancer. Tumori 2008; 94:271-277.
27. Yao B, He QM, Tian L, Xiao F, Jiang Y, Zhang R, et al. Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models. Hum Gene Ther 2005; 16:1075-1086.
28. Parhi P, Mohanty C, Sahoo SK. Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy. Drug Discov Today 2012; 17:1044-1052.
29. Shin HC, Alani AW, Cho H, Bae Y, Kolesar JM, Kwon GS. A 3-in-1 polymeric micelle nanocontainer for poorly water-soluble drugs. Mol Pharm 2011; 8:1257-1265.
30. Yokoyama T, Tam J, Kuroda S, Scott AW, Aaron J, Larson T, et al. EGFRtargeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells. PLoS One 2011; 6:e25507.
31. Bareford LM, Swaan PW. Endocytic mechanisms for targeted drug delivery. Adv Drug Deliv Rev 2007; 59:748-758.
32. Ganta S, Amiji M. Coadministration of Paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol Pharm 2009; 6:928-939.
33. Patil Y, Sadhukha T, Ma L, Panyam J. Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance. J Control Release 2009; 136:21-29.
34. Bremner P, Rivera D, Calzado MA, Obón C, Inocencio C, Beckwith C, et al. Assessing medicinal plants from South-Eastern Spain for potential antiinflammatory effects targeting nuclear factor-Kappa B and other proinflammatory mediators. J Ethnopharmacol 2009; 124:295-305.
35. Heinrichs S, Deppert W. Apoptosis or growth arrest: modulation of the cellular response to p53 by proliferative signals. Oncogene 2003; 22:555-571.
36. Hu YP, Henry-Toulmé N, Robert J. Failure of liposomal encapsulation of doxorubicin to circumvent multidrug resistance in an in vitro model of rat glioblastoma cells. Eur J Cancer 1995; 31A:389-394.