One step closer to sparing total blood loss and transfusion rate in total knee arthroplasty: a meta-analysis of different methods of tranexamic acid administration

Archives of Orthopaedic and Trauma Surgery

Volumn 135, Issue 4, 2015, Pages 573-588

  Shemshaki, Hamidreza ^a   Nourian, Sayed Mohammad Amin ^b   Nourian, Niloofaralsadat ^c   Dehghani, Masoudhatef ^d   Mokhtari, Masoud ^e   Mazoochian, Farhad ^f  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b CALIFORNIA STATE UNIVERSITY   (United States)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d Department of Orthopedic Surgery Saadi Hospital   (Iran)

^e ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f UNIVERSITY OF MUNICH   (Germany)

Author keywords

Intraarticular; Intravenous; Meta analysis; Total knee arthroplasty; Tranexamic acid

Indexed keywords

AMINOCAPROIC ACID; ANTIFIBRINOLYTIC AGENT; APROTININ; DESMOPRESSIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; TRANEXAMIC ACID;

ARTICLE; BLEEDING; BLOOD TRANSFUSION; DRUG EFFICACY; DRUG SAFETY; HUMAN; META ANALYSIS; PRIORITY JOURNAL; SYSTEMATIC REVIEW; SYSTEMIC THERAPY; THROMBOEMBOLISM; THROMBOSIS PREVENTION; TOPICAL TREATMENT; TOTAL KNEE REPLACEMENT; ADVERSE EFFECTS; BLOOD LOSS, SURGICAL; INTRAVENOUS DRUG ADMINISTRATION; KNEE ARTHROPLASTY; STATISTICS AND NUMERICAL DATA; UTILIZATION;

ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; HUMANS; INFUSIONS, INTRAVENOUS; TRANEXAMIC ACID;

EID: 84925482167     PISSN: 09368051     EISSN: 14343916     Source Type: Journal    
DOI: 10.1007/s00402-015-2189-7     Document Type: Article

References (57)

1. Kurtz S, Ong K, Lau E, Mowat F, Halpern M (2007) Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 89(4):780–785
2. Kirwan JR, Currey HL, Freeman MA, Snow S, Young PJ (1994) Overall long-term impact of total hip and knee joint replacement surgery on patients with osteoarthritis and rheumatoid arthritis. Br J Rheumatol 33(4):357–360
3. Prasad N, Padmanabhan V, Mullaji A (2007) Blood loss in total knee arthroplasty: an analysis of risk factors. Int Orthop 31(1):39–44
4. Cushner FD, Friedman RJ (1991) Blood loss in total knee arthroplasty. Clin Orthop Relat Res 269:98–101
5. Bower WF, Jin L, Underwood MJ, Lam YH, Lai PB (2010) Peri-operative blood transfusion increases length of hospital stay and number of postoperative complications in non-cardiac surgical patients. Hong Kong Med J 16(2):116–120
6. Spahn DR (2010) Anemia and patient blood management in hip and knee surgery: a systematic review of the literature. Anesthesiology 113(2):482–495
7. Rajesparan K, Biant LC, Ahmad M, Field RE (2009) The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement. J Bone Joint Surg Br 91(6):776–783
8. Zohar E, Ellis M, Ifrach N, Stern A, Sapir O, Fredman B (2004) The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg 99(6):1679–1683 (table of contents)
9. Eubanks JD (2010) Antifibrinolytics in major orthopaedic surgery. J Am Acad Orthop Surg 18(3):132–138
10. Mongan PD, Brown RS, Thwaites BK (1998) Tranexamic acid and aprotinin reduce postoperative bleeding and transfusions during primary coronary revascularization. Anesth Analg 87(2):258–265
11. Boylan JF, Klinck JR, Sandler AN, Arellano R, Greig PD, Nierenberg H et al (1996) Tranexamic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation. Anesthesiology 85(5):1043–1048 (discussion 30A–31A)
12. Wellington K, Wagstaff AJ (2003) Tranexamic acid: a review of its use in the management of menorrhagia. Drugs 63(13):1417–1433
13. Ipema HJ, Tanzi MG (2012) Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures. Ann Pharmacother 46(1):97–107
14. Gybel M, Kristensen K, Roseva-Nielsen N (2013) Cardiac arrest caused by massive pulmonary embolism during treatment with tranexamic acid. Ugeskr Laeger 175(20):1426–1427
15. Taparia M, Cordingley FT, Leahy MF (2002) Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia. Eur J Haematol 68(5):307–309
16. Krivokuca I, Lammers JW (2011) Recurrent pulmonary embolism associated with a hemostatic drug: tranexamic acid. Clin Appl Thromb Hemost Off J Int Acad Clin Appl Thromb Hemost 17(1):106–107
17. Bruce-Brand R, Dragomir R, Baker J, Harty J (2013) Cerebrovascular infarction following bilateral total knee arthroplasty and tranexamic acid administration. Acta Orthop Belg 79(3):351–354
18. Gandhi R, Evans HM, Mahomed SR, Mahomed NN (2013) Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis. BMC Res Notes 6:184
19. Tan J, Chen H, Liu Q, Chen C, Huang W (2013) A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res 184(2):880–887
20. Alshryda S, Sukeik M, Sarda P, Blenkinsopp J, Haddad FS, Mason JM (2014) A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J 96-B(8):1005–1015
21. Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W (2009) Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thrombosis Res 123(5):687–696
22. Sa-Ngasoongsong P, Channoom T, Kawinwonggowit V, Woratanarat P, Chanplakorn P, Wibulpolprasert B et al (2011) Postoperative blood loss reduction in computer-assisted surgery total knee replacement by low dose intra-articular tranexamic acid injection together with 2-hour clamp drain: a prospective triple-blinded randomized controlled trial. Orthop Rev 3(2):e12
23. Sa-Ngasoongsong P, Wongsak S, Chanplakorn P, Woratanarat P, Wechmongkolgorn S, Wibulpolprasert B et al (2013) Efficacy of low-dose intra-articular tranexamic acid in total knee replacement; a prospective triple-blinded randomized controlled trial. BMC Musculoskelet Disord 14:340
24. Alshryda S, Mason J, Vaghela M, Sarda P, Nargol A, Maheswaran S et al (2013) Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total knee replacement: a randomized controlled trial (TRANX-K). J Bone Joint Surg Am 95(21):1961–1968
25. Alvarez JC, Santiveri FX, Ramos I, Vela E, Puig L, Escolano F (2008) Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion 48(3):519–525
26. Benoni G, Fredin H (1996) Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg Br 78(3):434–440
27. Camarasa MA, Olle G, Serra-Prat M, Martin A, Sanchez M, Ricos P et al (2006) Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 96(5):576–582
28. Chareancholvanich K, Siriwattanasakul P, Narkbunnam R, Pornrattanamaneewong C (2012) Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial. BMC Musculoskelet Disord 13:124
29. Ellis MH, Fredman B, Zohar E, Ifrach N, Jedeikin R (2001) The effect of tourniquet application, tranexamic acid, and desmopressin on the procoagulant and fibrinolytic systems during total knee replacement. J Clin Anesth 13(7):509–513
30. Georgiadis AG, Muh SJ, Silverton CD, Weir RM, Laker MW (2013) A prospective double-blind placebo controlled trial of topical tranexamic acid in total knee arthroplasty. J Arthroplasty 28(8 Suppl):78–82
31. Good L, Peterson E, Lisander B (2003) Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 90(5):596–599
32. Hiippala S, Strid L, Wennerstrand M, Arvela V, Mantyla S, Ylinen J et al (1995) Tranexamic acid (cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 74(5):534–537
33. Hiippala ST, Strid LJ, Wennerstrand MI, Arvela JV, Niemela HM, Mantyla SK et al (1997) Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anesth Analg 84(4):839–844
34. Jansen AJ, Andreica S, Claeys M, D’Haese J, Camu F, Jochmans K (1999) Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty. Br J Anaesth 83(4):596–601
35. Kakar PN, Gupta N, Govil P, Shah V (2009) Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial. Indian J Anaesth 53(6):667–671
36. Lee SH, Cho KY, Khurana S, Kim KI (2013) Less blood loss under concomitant administration of tranexamic acid and indirect factor Xa inhibitor following total knee arthroplasty: a prospective randomized controlled trial. Knee Surg Sports Traumatol Arthrosc Off J ESSKA 21(11):2611–2617
37. MacGillivray RG, Tarabichi SB, Hawari MF, Raoof NT (2011) Tranexamic acid to reduce blood loss after bilateral total knee arthroplasty: a prospective, randomized double blind study. J Arthroplasty 26(1):24–28
38. Martin JG, Cassatt KB, Kincaid-Cinnamon KA, Westendorf DS, Garton AS, Lemke JH (2014) Topical administration of tranexamic acid in primary total hip and total knee arthroplasty. J Arthroplasty 29(5):889–894
39. Oremus K, Sostaric S, Trkulja V, Haspl M (2014) Influence of tranexamic acid on postoperative autologous blood retransfusion in primary total hip and knee arthroplasty: a randomized controlled trial. Transfusion 54(1):31–41
40. Orpen NM, Little C, Walker G, Crawfurd EJ (2006) Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients. Knee 13(2):106–110
41. Roy SP, Tanki UF, Dutta A, Jain SK, Nagi ON (2012) Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc Off J ESSKA 20(12):2494–2501
42. Wong J, Abrishami A, El Beheiry H, Mahomed NN, Roderick Davey J, Gandhi R et al (2010) Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am 92(15):2503–2513
43. Molloy DO, Archbold HA, Ogonda L, McConway J, Wilson RK, Beverland DE (2007) Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br 89(3):306–309
44. McConnell JS, Shewale S, Munro NA, Shah K, Deakin AH, Kinninmonth AW (2012) Reducing blood loss in primary knee arthroplasty: a prospective randomised controlled trial of tranexamic acid and fibrin spray. Knee 19(4):295–298
45. Maniar RN, Kumar G, Singhi T, Nayak RM, Maniar PR (2012) Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res 470(9):2605–2612
46. Aguilera X, Martinez-Zapata MJ, Bosch A, Urrutia G, Gonzalez JC, Jordan M et al (2013) Efficacy and safety of fibrin glue and tranexamic acid to prevent postoperative blood loss in total knee arthroplasty: a randomized controlled clinical trial. J Bone Joint Surg Am 95(22):2001–2007
47. Engel JM, Hohaus T, Ruwoldt R, Menges T, Jurgensen I, Hempelmann G (2001) Regional hemostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin. Anesth Analg 92(3):775–780
48. Ishida K, Tsumura N, Kitagawa A, Hamamura S, Fukuda K, Dogaki Y et al (2011) Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty. Int Orthop 35(11):1639–1645
49. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S (2001) Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg Br 83(5):702–705
50. Veien M, Sorensen JV, Madsen F, Juelsgaard P (2002) Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study. Acta Anaesthesiol Scand 46(10):1206–1211
51. Zhang F, Gao Z, Yu J (2007) [Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty. Zhongguo xiu fu chong jian wai ke za zhi 21(12):1302–1304
52. Mylod AG Jr, France MP, Muser DE, Parsons JR (1990) Perioperative blood loss associated with total knee arthroplasty. A comparison of procedures performed with and without cementing. J Bone Joint Surg Am 72(7):1010–1012
53. Raut VV, Stone MH, Wroblewski BM (1993) Reduction of postoperative blood loss after press-fit condylar knee arthroplasty with use of a femoral intramedullary plug. J Bone Joint Surg Am 75(9):1356–1357
54. Modig J, Karlstrom G (1987) Intra- and post-operative blood loss and haemodynamics in total hip replacement when performed under lumbar epidural versus general anaesthesia. Eur J Anaesthesiol 4(5):345–355
55. Soni A, Saini R, Gulati A, Paul R, Bhatty S, Rajoli SR (2014) Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplasty. J Arthroplasty 29(8):1525–1527
56. Patel JN, Spanyer JM, Smith LS, Huang J, Yakkanti MR, Malkani AL (2014) Comparison of intravenous versus topical tranexamic acid in total knee arthroplasty: a prospective randomized study. J Arthroplasty 29(8):1528–1531
57. White RH, Romano PS, Zhou H, Rodrigo J, Bargar W (1998) Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty. Arch Intern Med 158(14):1525–1531