Tranexamic Acid to Reduce Blood Loss After Bilateral Total Knee Arthroplasty. A Prospective, Randomized Double Blind Study

Journal of Arthroplasty

Volumn 26, Issue 1, 2011, Pages 24-28

  MacGillivray, Robin G ^a   Tarabichi, Samih B ^a   Hawari, Marwan F ^a   Raoof, Nayzak T ^a  

^a American Hospital Dubai   (United Arab Emirates)

Author keywords

Bilateral total knee arthroplasty; Blood loss; Tranexamic acid; Transfusion

Indexed keywords

PLACEBO; SODIUM CHLORIDE; TRANEXAMIC ACID;

ADULT; AGED; ARTICLE; BLOOD AUTOTRANSFUSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; RANDOMIZED CONTROLLED TRIAL; TOTAL KNEE REPLACEMENT;

AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD TRANSFUSION, AUTOLOGOUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; PULMONARY EMBOLISM; TRANEXAMIC ACID;

EID: 78649998768     PISSN: 08835403     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arth.2009.11.013     Document Type: Article

References (18)

1. Dunn C.J., Goa K.L. Tranexamic acid. A review of its use in surgery and other indications. Drugs 1999, 57:1005.
2. Ahlberg A., Eriksson O., Kjellman H. Diffusion of tranexamic acid to the joint. Acta Orthop Scand 1976, 47:486.
3. Ho K.M., Ismail H. Use of intravenous tranexamic acid to reduce allogenic blood transfusion in total hip and knee arthroplasty: a meta-analysis. Anaesth Intensive Care 2003, 31:529.
4. Cid J., Lozano M. Tranexamic acid reduces allogenic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials. Transfusion 2005, 45:1302.
5. Hiippala S., Strid L., Wennerstrand M., et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 1995, 74:534.
6. Benoni G., Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty. J Bone Joint Surg [Br] 1996, 78:434.
7. Jansen A.J., Andreica S., Claeys M., et al. Use of tranexamic acid for an effective blood conservation strategy after total knee arthroplasty. Br J Anaesth 1999, 83:596.
8. Tanaka N., Sakahashi H., Sato E., et al. Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg [Br] 2001, 83-B:702.
9. Veien M., Sorensen J.V., Madsen F., et al. Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized controlled study. Acta Anaesthesiol Scand 2002, 46:1206.
10. Good L., Petersen E., Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 2003, 90:596.
11. Camarasa M.A., Olle G., Serra-Prat M., et al. Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement. Br J Anaesth 2006, 96:576.
12. Spahn D.R., Casutt M. Eliminating blood transfusions. New aspects and perspectives. Anesthesiology 2000, 93:242.
13. Roysam G.S., Oakley M.J. Subvastus approach for total knee arthroplasty: a prospective randomised and observer-blinded trial. J Arthroplasty 2001, 16:454.
14. Boerger T.O., Aglietti P., Mondarelli N., et al. Mini-subvastus versus medial prepatellar approach in total knee arthroplasty. Clin Orthop Relat Res 2005, 440:82.
15. Barrett J., Baron J.A., Losina E., et al. Bilateral total knee replacement: staging and pulmonary embolism. J Bone Joint Surg (Am) 2006, 88:2146.
16. Pookaranjanamorakot C., Sirisriro R., Eurvilaichit C., et al. The incidence of deep vein thrombosis and pulmonary embolism after total knee arthroplasty: the screening study by radionuclide venography. J Med Assoc Thai 2004, 87:869.
17. National Institutes of Health Consensus Development Program 2003.
18. Eriksson B.I., Dahl O.E., Rosencher N., et al. Oral dabigatran etixalate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007, 5:2178.