Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: A prospective, randomised, double-blind study of 86 patients

Journal of Bone and Joint Surgery - Series B

Volumn 78, Issue 3, 1996, Pages 434-440

  Benoni, Göran ^a   Fredin, Hans ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

TRANEXAMIC ACID;

AGED; ARTICLE; BLOOD TRANSFUSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FIBRINOLYSIS; HEMOGLOBIN DETERMINATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; KNEE ARTHROPLASTY; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THROMBOEMBOLISM; TOURNIQUET;

EID: 0029891721     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620x.78b3.0780434     Document Type: Article

References (37)

1. Ali IM, Landymore RW. The use of tranexamic acid in cardiac operations (letter). J Thorac Cardiovasc Surg 1994;107:1377.
2. Åstedt B, Liedholm P, Wingerup L. The effect of tranexamic acid on the fibrinolytic activity of vein walls. Ann Chir Gynaecol 1978;67: 203-5.
3. Åstedt B, Sheppard BL, Soma H. Tranexamic acid: a potent inhibitor of fibrinolysis: a review of its pharmacology and clinical use. Osaka: Adis Int Limited, 1991.
4. Becker J, Borgström S. Incidence of thrombosis associated with epsilon-aminocaproic acid administration and with combined epsilon-aminocaproic acid and subcutaneous heparin therapy. Acta Chir Scand 1968;134:343-9.
5. Bekassy Z, Åstedt B. Treatment with the fibrinolytic inhibitor tranexamic acid: risk for thrombosis? Acta Obstet Gynecol Scand 1990;69:353-4.
6. Benoni G, Björkman S, Fredin H. Application of pharmacokinetic data from healthy volunteers for the prediction of plasma concentrations of tranexamic acid in surgical patients. Clin Drug Invest 1995;10: 280-7.
7. Benoni G, Carlsson Å, Petersson C, Fredin H. Does tranexamic acid reduce blood loss in knee arthroplasty? Acta Orthop Scand 1994; 65:Suppl 256:101.
8. Benoni G, Carlsson Å, Petersson C, Fredin H. Does tranexamic acid reduce blood loss in knee arthroplasty? Am J Knee Surg 1995; 8:88-92.
9. Björkman SE, Nilsson IM. Demonstration of a fibrinolytic activator in red bone marrow. Acta Haematol 1961;26:273-80.
10. Carlin G, Karlström G, Modig J, Saldeen T. Effect of Dextran on fibrinolysis inhibition activity in the blood after major surgery. Acta Anaesthesiol Scand 1980;24:375-8.
11. Collins DN, Heim SA, Nelson CL, Smith P. Porous-coated anatomic total knee arthroplasty: a prospective analysis comparing cemented and cementless fixation. Clin Orthop 1991;267:128-36.
12. Cushner FD, Friedman RJ. Blood loss in total knee arthroplasty. Clin Orthop 1991;269:98-101.
13. Eriksson BI. Thromboembolism after total hip replacement: relationship to the fibrinolytic system. Thesis. Göteborg University, Sweden, 1991.
14. Eriksson BI, Zachrisson BE, Teger-Nilsson A-C, Risberg B. Thrombosis prophylaxis with low molecular weight heparin in total hip replacement Br J Surg 1988;75:1053-7.
15. Fahmy NR, Patel DG. Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet. J Bone Joint Surg [Am] 1981;63-A:461-5.
16. Flordal PA, Sahlin S. Use of desmopressin to prevent bleeding complications in patients treated with aspirin. Br J Surg 1993;80:723-4.
17. Gordon-Smith IC, Hickman JA, El Masri SH. The effect of the fibrinolytic inhibitor epsilon-aminocaproic acid on the incidence of deep-vein thrombosis after prostatectomy. Br J Surg 1972;59:522-4.
18. Hedlund PO. Antifibrinolytic therapy with Cyklokapron in connection with prostatectomy: a double blind study. Scand J Urol Nephrol 1969;3:177-82.
19. Hedlund PO. Postoperative venous thrombosis in benign prostatic disease: a study of 316 patients, using the 1251-fibrinogen uptake test. Scand J Urol Nephrol 1975;Suppl 27:1-100.
20. Hiippala S, Strid L, Wennerstrand M, et al. Tranexamic acid (cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 1995;74:534-7.
21. Högman CF, Hedlund K, Åkerblom O, Venge P. Red blood cell preservation in protein-poor media I. Leukocyte enzymes as a cause of hemolysis. Transfusion 1978;18:233-41.
22. Horrow J, Strong MD, Van Riper DF. Tranexamic acid after bypass: too late to help? (Letter). J Thorac Cardiovasc Surg 1994;107:1375-6.
23. Horrow JC, Hlavacek J, Strong MD, et al. Prophylactic tranexamic acid decreases bleeding after cardiac operations. J Thorac Cardiovasc Surg 1990;99:70-4.
24. Hunt BJ. Modifying perioperative blood loss. Blood Rev 1991;5: 168-76.
25. Janssens M, Joris J, David JL, Lemaire R, Lamy M. High-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery. Anesthesiology 1994;80:23-9.
26. Kenny GN. Potential renal, haematological and allergic adverse effects associated with non-steroidal anti-inflammatory drugs. Drug 1992;44:Suppl 5:31-7.
27. Kluft C, Verheijen JH, Jie AF, et al. The postoperative fibrinolytic shutdown: a rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma. Scand J Clin Lab Invest 1985;45:605-10.
28. Levy JH. Aspirin and bleeding after coronary artery bypass: grafting (editorial). Anesth Analg 1994;79:1-3.
29. Lotke PA, Faralli VJ, Orenstein EM, Ecker ML. Blood loss after total knee replacement: effects of tourniquet release and continuous passive motion. J Bone Joint Surg [Am] 1991;73-A:1037-40.
30. Modig J, Borg T, Bagge L, Saldeen T. Role of extradural and of general anaesthesia in fibrinolysis and coagulation after total hip replacement. Br J Anaesth 1983;55:625-9.
31. Modig J, Karlström G. Intra- and post-operative blood loss and haemodynamics in total hip replacement when performed under lumbar epidural versus general anaesthesia. Eur J Anaesthesiol 1987;4: 345-55.
32. Mylod AG, France MP, Muser DE, Parsons JR. Perioperative blood loss associated with total knee arthroplasty: a comparison of procedures performed with and without cementing. J Bone Joint Surg [Am] 1990;72-A:1010-2.
33. Nilsson IM. Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol Suppl R Coll Pathol 1980;14:41-7.
34. Raut VV, Stone MH, Wroblewski BM. Reduction of postoperative blood loss after press-fit condylar knee arthroplasty with use of a femoral intramedullary plug. J Bone Joint Surg [Am] 1993;75-A:1356-7.
35. Risberg B. The response of the fibrinolytic system in trauma. Acta Chir Scand 1985;Suppl 522:245-71.
36. Royston D. Perioperative bleeding: drugs for surgical blood loss. Lancet 1993;341:1629.
37. Verstraete M. Clinical application of inhibitors of fibrinolysis. Drugs 1985;29:236-61.