Reducing blood loss in primary knee arthroplasty: A prospective randomised controlled trial of tranexamic acid and fibrin spray

Knee

Volumn 19, Issue 4, 2012, Pages 295-298

  McConnell, Jamie S ^a   Shewale, Sandeep ^b   Munro, Niall A ^c   Shah, Kalpesh ^c   Deakin, Angela H ^c   Kinninmonth, Andrew W G ^c  

^a ROYAL NATIONAL ORTHOPAEDIC HOSPITAL   (United Kingdom)

^b MONKLANDS HOSPITAL   (United Kingdom)

^c GOLDEN JUBILEE NATIONAL HOSPITAL   (United Kingdom)

Author keywords

Arthroplasty; Fibrin tissue adhesive; Knee; Tranexamic acid

Indexed keywords

FIBRIN; QUIXIL; TRANEXAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BODY MASS; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HEMATOCRIT; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; TOTAL KNEE REPLACEMENT;

ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; FIBRIN; FIBRINOGEN; FIBRONECTINS; HUMANS; PROSPECTIVE STUDIES; THROMBIN; TRANEXAMIC ACID;

EID: 84861710918     PISSN: 09680160     EISSN: 18735800     Source Type: Journal    
DOI: 10.1016/j.knee.2011.06.004     Document Type: Article

References (23)

1. Levy O., Martinowitz U., Oran A., Tauber C., Horoszowski H. The use of fibrin tissue adhesive to reduce blood loss and the need for blood transfusion after total knee arthroplasty. A prospective, randomized, multicenter study. J Bone Joint Surg Am 1999, 81:1580-1588.
2. Lemaire R. Strategies for blood management in orthopaedic and trauma surgery. J Bone Joint Surg Br 2008, 90:1128-1136.
3. Tobias J. Strategies for minimizing blood loss in orthopedic surgery. Semin Hematol 2004, 41:145-156.
4. Moonen A.F., Neal T.D., Pilot P. Peri-operative blood management in elective orthopaedic surgery. A critical review of the literature. Injury 2006, 37(Suppl. 5):S11-6.
5. Alvarez J.C., Santiveri F.X., Ramos I., Vela E., Puig L., Escolano F. Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion 2008, 48:519-525.
6. Hiippala S.T., Strid L.J., Wennerstrand M.I., Arvela J.V., Niemelä H.M., Mäntylä S.K., et al. Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anesth Analg 1997, 84:839-844.
7. Benoni G., Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg Br 1996, 78:434-440.
8. Ho K.M., Ismail H. Use of intravenous tranexamic acid to reduce allogeneic blood transfusion in total hip and knee arthroplasty: a meta-analysis. Anaesth Intensive Care 2003, 31:529-537.
9. Zohar E., Ellis M., Ifrach N., Stern A., Sapir O., Fredman B. The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg 2004, 99:1679-1683.
10. Wang G.J., Hungerford D.S., Savory C.G., Rosenberg A.G., Mont M.A., Burks S.G., et al. Use of fibrin sealant to reduce bloody drainage and hemoglobin loss after total knee arthroplasty: a brief note on a randomized prospective trial. J Bone Joint Surg Am 2001, 83-A:1503-1505.
11. Molloy D.O., Archbold H.A., Ogonda L., McConway J., Wilson R.K., Beverland D.E. Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br 2007, 89:306-309.
12. Doig G.S., Simpson F. Randomization and allocation concealment: a practical guide for researchers. J Crit Care 2005, 20:187-191.
13. Scottish Intercollegiate Guidelines Network National clinical guideline 62: prophylaxis of venous thromboembolism 2002, 17-20.
14. Sehat K., Evans R., Newman J. Hidden blood loss following hip and knee arthroplasty. Correct management of blood loss should take hidden loss into account. J Bone Joint Surg Br 2004, 86:561-565.
15. Nadler S.B. Prediction of blood volume in normal human adults. Surgery 1962, 52:224-232.
16. Cid J., Lozano M. Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials. Transfusion 2005, 45:1302-1307.
17. Zufferey P., Merquiol F., Laporte S., Decousus H., Mismetti P., Auboyer C., et al. Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery?. Anesthesiology 2006, 105:1034-1046.
18. Everts P.A., Devilee R.J., Oosterbos C.J., Mahoney C.B., Schattenkerk M.E., Knape J.T., et al. Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis. Knee Surg Sports Traumatol Arthrosc 2007, 15:888-894.
19. Kalairajah Y., Simpson D., Cossey A.J., Verrall G.M., Spriggins A.J. Blood loss after total knee replacement: effects of computer-assisted surgery. J Bone Joint Surg Br 2005, 87:1480-1482.
20. Scottish Intercollegiate Guidelines Network National clinical guideline 54: perioperative blood transfusion for elective surgery. Section 7: orthopaedic surgery 2001, 21-23.
21. Hynes M., Calder P., Scott G. The use of tranexamic acid to reduce blood loss during total knee arthroplasty. Knee 2003, 10:375-377.
22. Orpen N.M., Little C., Walker G., Crawfurd E.J. Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients. Knee 2006, 13:106-110.
23. Benoni G., Bjorkman S., Fredin H. Application of pharmacokinetic data from healthy volunteers for the prediction of plasma concentrations of tranexamic acid in surgical patients. Clin Drug Invest 1995, 10:280-287.