Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total knee replacement: A randomized controlled trial (TRANX-K)

Journal of Bone and Joint Surgery

Volumn 95, Issue 21, 2013, Pages 1961-1968

  Alshryda, Sattar ^a   Mason, James ^b   Vaghela, Manesh ^c   Sarda, Praveen ^c   Nargol, Antoni ^c   Maheswaran, S ^c   Tulloch, Chris ^c   Anand, Sanjeev ^c   Logishetty, Raj ^c   Stothart, Brian ^c   Hungin, A Pali S ^b  

^a JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

^c UNIVERSITY HOSPITAL OF NORTH TEES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; TINZAPARIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT; WARFARIN;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CLINICAL PROTOCOL; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; FEMALE; HEMOGLOBIN DETERMINATION; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OSTEOARTHRITIS; OXFORD KNEE SCORE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SURGICAL RISK; THROMBOEMBOLISM; THROMBOSIS PREVENTION; TOTAL KNEE REPLACEMENT; TREATMENT OUTCOME; VISUAL ANALOG SCALE; BLOOD LOSS, SURGICAL; HIP ARTHROPLASTY; INTRAARTICULAR DRUG ADMINISTRATION; VERY ELDERLY; ALLERGY; BOOTSTRAPPING; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROL STRATEGY; DEEP VEIN THROMBOSIS; DEPENDENT VARIABLE; DISLOCATION; DOPPLER ECHOGRAPHY; DRUG EFFECT; DRUG WITHDRAWAL; GENERIC QUALITY OF LIFE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HOSPITALIZATION; INFECTION; INTENTION TO TREAT ANALYSIS; INTERNATIONAL NORMALIZED RATIO; LOGISTIC REGRESSION ANALYSIS; METAL ALLERGY; OXFORD HIP SCORE; RISK REDUCTION; SENSITIVITY ANALYSIS; SIDE EFFECT; SUPERFICIAL INFECTION; TOTAL HIP PROSTHESIS; UNILATERAL PRIMARY TOTAL HIP REPLACEMENT; CONTROLLED CLINICAL TRIAL; OPERATIVE BLOOD LOSS;

AGED; AGED, 80 AND OVER; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INJECTIONS, INTRA-ARTICULAR; MALE; MIDDLE AGED; TRANEXAMIC ACID; TREATMENT OUTCOME;

EID: 84891588514     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.L.00907     Document Type: Article

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