A Prospective double-blind placebo controlled trial of topical tranexamic acid in total knee arthroplasty

Journal of Arthroplasty

Volumn 28, Issue 8 SUPPL, 2013, Pages 78-82

  Georgiadis, Andrew G ^a   Muh, Stephanie J ^a   Silverton, Craig D ^a   Weir, Robb M ^a   Laker, Michael W ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Blood loss; Total knee arthroplasty; Tranexamic acid

Indexed keywords

ENOXAPARIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; TRANEXAMIC ACID; WARFARIN;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CONTROLLED STUDY; DEBRIDEMENT; DEEP VEIN THROMBOSIS; DOUBLE BLIND PROCEDURE; EMBOLISM PREVENTION; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SURGICAL TECHNIQUE; THROMBOSIS PREVENTION; TOTAL KNEE REPLACEMENT; ULTRASOUND; VENOUS THROMBOEMBOLISM; WOUND DEHISCENCE; WOUND IRRIGATION;

BLOOD LOSS; TOTAL KNEE ARTHROPLASTY; TRANEXAMIC ACID;

ADMINISTRATION, TOPICAL; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; TRANEXAMIC ACID; VENOUS THROMBOSIS;

EID: 84884161814     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2013.03.038     Document Type: Article

References (36)

1. Shander A., Hofmann A., Ozawa S., et al. Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion 2010, 50:753.
2. Yang Z.G., Chen W.P., Wu L.D. Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg Am 2012, 94:1153.
3. Zhang H., Chen J., Chen F., et al. The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthroscop 2012, 20:1742.
4. Wong J., Abrishami A., El Beheiry H., et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am 2010, 92:2503.
5. Seo J.G., Moon Y.W., Park S.H., et al. The comparative efficacies of intra-articular and iv tranexamic acid for reducing blood loss during total knee arthroplasty. Knee Surg Sports. Traumatol Arthroscop 2012, 10.1007/s00167-012-2079-2.
6. Nadler S.B., Hidalgo J.H., Bloch T. Prediction of blood volume in normal human adults. Surgery 1962, 51:224.
7. Good L., Peterson E., Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 2003, 90:596.
8. Bierbaum B.E., Callaghan J.J., Galante J.O., et al. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am 1999, 81:2.
9. Raut S., Mertes S.C., Muniz-Terrera G., et al. Factors associated with prolonged length of stay following a total knee replacement in patients aged over 75. Int Orthop 2012, 36:1601.
10. Diamond P.T., Conaway M.R., Mody S.H., et al. Influence of hemoglobin levels on inpatient rehabilitation outcomes after total knee arthroplasty. J Arthroplasty 2006, 21:636.
11. Guerriero C., Cairns J., Jayaraman S., et al. Giving tranexamic acid to reduce surgical bleeding in sub-saharan africa: an economic evaluation. Cost Eff Resour Alloc 2010, 8:1.
12. Coker N., Higgins D.J. Tranexamic acid applied topically to achieve haemostasis. Anaesthesia 2000, 55:600.
13. Waly N.G. Local antifibrinolytic treatment with tranexamic acid in hemophilic children undergoing dental extractions. Egypt Dent J 1995, 41:961.
14. Pell G. Tranexamic acid-its use in controlling dental post-operative bleeding in patients with defective clotting mechanisms. Br J Oral Surg 1973, 11:155.
15. Sarris I., Arafa A., Konaris L., et al. Topical use of tranexamic acid to control perioperative local bleeding in gynaecology patients with clotting disorders: two cases. Haemophilia 2007, 13:115.
16. Krohn C.D., Sorensen R., Lange J.E., et al. Tranexamic acid given into the wound reduces postoperative blood loss by half in major orthopaedic surgery. Eur J Surg Suppl 2003, 57.
17. Maniar R.N., Kumar G., Singhi T., et al. Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Rel Res 2012, 470:2605.
18. Shakur H., Roberts I., Bautista R., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010, 376:23.
19. Zufferey P.J., Miquet M., Quenet S., et al. Tranexamic acid in hip fracture surgery: a randomized controlled trial. Br J Anaesthesia 2010, 104:23.
20. Chareancholvanich K., Siriwattanasakul P., Narkbunnam R., et al. Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial. BMC Musculoskelet Disord 2012, 13:124.
21. Lin P.C., Hsu C.H., Huang C.C., et al. The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional pre-operative injection effective?. J Bone Joint Surg Br 2012, 94:932.
22. Imai N., Dohmae Y., Suda K., et al. Tranexamic acid for reduction of blood loss during total hip arthroplasty. J Arthroplasty 2012, 27:1838.
23. Clave A., Fazilleau F., Dumser D., et al. Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement with rivaroxaban thromboprophylaxis: a case-control study in 70 patients. Orthop Traumatol Surg Res 2012, 98:484.
24. Porte R.J., Leebeek F.W. Pharmacological strategies to decrease transfusion requirements in patients undergoing surgery. Drugs 2002, 62:2193.
25. Molloy D.O., Archbold H.A., Ogonda L., et al. Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br 2007, 89:306.
26. McConnell J.S., Shewale S., Munro N.A., et al. Reducing blood loss in primary knee arthroplasty: a prospective randomised controlled trial of tranexamic acid and fibrin spray. Knee 2012, 19:295.
27. Tobias J.D. Strategies for minimizing blood loss in orthopedic surgery. Semin Hematol 2004, 41:145.
28. Reust D.L., Reeves S.T., Abernathy J.H., et al. Temporally and regionally disparate differences in plasmin activity by tranexamic acid. Anesth Analg 2010, 110:694.
29. MacGillivray R.G., Tarabichi S.B., Hawari M.F., et al. Tranexamic acid to reduce blood loss after bilateral total knee arthroplasty: a prospective, randomized double blind study. J Arthroplasty 2011, 26:24.
30. Abul-Azm A., Abdullah K.M. Effect of topical tranexamic acid in open heart surgery. Eur J Anaesthesiol 2006, 23:380.
31. Spegar J., Vanek T., Snircova J., et al. Local and systemic application of tranexamic acid in heart valve surgery: a prospective, randomized, double blind lost study. J Thromb Thrombolysis 2011, 32:303.
32. Imbesi S., Nettis E., Minciullo P.L., et al. Hypersensitivity to tranexamic acid: a wide spectrum of adverse reactions. Pharm World Sci 2010, 32:416.
33. Aguilera X., Videla S., Almenara M., et al. Effectiveness of tranexamic acid in revision total knee arthroplasty. Acta Orthop Belg 2012, 78:68.
34. Abdollahi M., Cushman M., Rosendaal F.R. Obesity: risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive use. Thromb Haemost 2003, 89:493.
35. Kearon C. Natural history of venous thromboembolism. Circulation 2003, 107:I22.
36. Gillette B.P., Desimone L.J., Trousdale R.T., et al. Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthroplasty. Clin Orthop Rel Res 2013, 471(1):150.