메뉴 건너뛰기




Volumn 64, Issue 2, 2015, Pages 213-224

Immune impairments in multiple myeloma bone marrow mesenchymal stromal cells

Author keywords

Immunomodulation; MSCs; Myeloma; Th17 Treg

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; AUTACOID; CYTOKINE;

EID: 84925482125     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-014-1623-y     Document Type: Article
Times cited : (46)

References (49)
  • 1
    • 6944235003 scopus 로고    scopus 로고
    • Multiple myeloma
    • COI: 1:CAS:528:DC%2BD2cXptFChtLk%3D, PID: 15509819
    • Kyle RA, Rajkumar SV (2004) Multiple myeloma. N Engl J Med 351:1860–1873. doi:10.1056/NEJMra041875
    • (2004) N Engl J Med , vol.351 , pp. 1860-1873
    • Kyle, R.A.1    Rajkumar, S.V.2
  • 2
    • 79960880111 scopus 로고    scopus 로고
    • Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression?
    • COI: 1:CAS:528:DC%2BC3MXht12rtbvK, PID: 21659611
    • Tucci M, Stucci S, Strippoli S, Dammacco F, Silvestris F (2011) Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression? Oncologist 16:1040–1048. doi:10.1634/theoncologist.2010-0327
    • (2011) Oncologist , vol.16 , pp. 1040-1048
    • Tucci, M.1    Stucci, S.2    Strippoli, S.3    Dammacco, F.4    Silvestris, F.5
  • 3
    • 34547677725 scopus 로고    scopus 로고
    • Immunodeficiency and immunotherapy in multiple myeloma
    • COI: 1:CAS:528:DC%2BD2sXhtVKgsr7O, PID: 17686051
    • Pratt G, Goodyear O, Moss P (2007) Immunodeficiency and immunotherapy in multiple myeloma. Br J Haematol 138:563–579. doi:10.1111/j.1365-2141.2007.06705.x
    • (2007) Br J Haematol , vol.138 , pp. 563-579
    • Pratt, G.1    Goodyear, O.2    Moss, P.3
  • 4
    • 0032873880 scopus 로고    scopus 로고
    • Immune regulation in multiple myeloma: the host–tumour conflict
    • COI: 1:STN:280:DyaK1MvlsVeqsw%3D%3D, PID: 10527267
    • Cook G, Campbell JD (1999) Immune regulation in multiple myeloma: the host–tumour conflict. Blood Rev 13:151–162. doi:10.1054/blre.1999.0111
    • (1999) Blood Rev , vol.13 , pp. 151-162
    • Cook, G.1    Campbell, J.D.2
  • 5
    • 58849093606 scopus 로고    scopus 로고
    • CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+)CD4(-)CD8(-)alphabetaTCR(+) Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden
    • PID: 19133978
    • Feyler S, von Lilienfeld-Toal M, Jarmin S, Marles L, Rawstron A, Ashcroft AJ, Owen RG, Selby PJ, Cook G (2009) CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+)CD4(-)CD8(-)alphabetaTCR(+) Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden. Br J Haematol 144:686–695. doi:10.1111/j.1365-2141.2008.07530.x
    • (2009) Br J Haematol , vol.144 , pp. 686-695
    • Feyler, S.1    von Lilienfeld-Toal, M.2    Jarmin, S.3    Marles, L.4    Rawstron, A.5    Ashcroft, A.J.6    Owen, R.G.7    Selby, P.J.8    Cook, G.9
  • 7
    • 84860476030 scopus 로고    scopus 로고
    • Increased numbers of T helper 17 cells and the correlation with clinicopathological characteristics in multiple myeloma
    • COI: 1:CAS:528:DC%2BC38Xpsl2mt7Y%3D, PID: 22613416
    • Shen CJ, Yuan ZH, Liu YX, Hu GY (2012) Increased numbers of T helper 17 cells and the correlation with clinicopathological characteristics in multiple myeloma. J Int Med Res 40:556–564
    • (2012) J Int Med Res , vol.40 , pp. 556-564
    • Shen, C.J.1    Yuan, Z.H.2    Liu, Y.X.3    Hu, G.Y.4
  • 9
    • 78650749445 scopus 로고    scopus 로고
    • Impairment in immunomodulatory function of mesenchymal stem cells from multiple myeloma patients
    • COI: 1:CAS:528:DC%2BC3MXhtVegtw%3D%3D, PID: 21199732
    • Li B, Fu J, Chen P, Zhuang W (2010) Impairment in immunomodulatory function of mesenchymal stem cells from multiple myeloma patients. Arch Med Res 41:623–633. doi:10.1016/j.arcmed.2010.11.008
    • (2010) Arch Med Res , vol.41 , pp. 623-633
    • Li, B.1    Fu, J.2    Chen, P.3    Zhuang, W.4
  • 10
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • PID: 11986244
    • Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, Grisanti S, Gianni AM (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838–3843
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6    Grisanti, S.7    Gianni, A.M.8
  • 11
    • 77956215701 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype
    • COI: 1:CAS:528:DC%2BC3cXns1CqsrY%3D, PID: 20511548
    • Ghannam S, Pene J, Torcy-Moquet G, Jorgensen C, Yssel H (2010) Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol 185:302–312. doi:10.4049/jimmunol.0902007
    • (2010) J Immunol , vol.185 , pp. 302-312
    • Ghannam, S.1    Pene, J.2    Torcy-Moquet, G.3    Jorgensen, C.4    Yssel, H.5
  • 13
    • 77957338676 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: facilitators of successful transplantation?
    • COI: 1:CAS:528:DC%2BC3cXht1ClsLfP, PID: 20887949
    • English K, French A, Wood KJ (2010) Mesenchymal stromal cells: facilitators of successful transplantation? Cell Stem Cell 7:431–442. doi:10.1016/j.stem.2010.09.009
    • (2010) Cell Stem Cell , vol.7 , pp. 431-442
    • English, K.1    French, A.2    Wood, K.J.3
  • 14
    • 84875329801 scopus 로고    scopus 로고
    • Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells
    • COI: 1:CAS:528:DC%2BC3sXlsVSrtL4%3D, PID: 23555770
    • Andre T, Meuleman N, Stamatopoulos B, De BC, Pieters K, Bron D, Lagneaux L (2013) Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells. PLoS One 8:e59756. doi:10.1371/journal.pone.0059756
    • (2013) PLoS One , vol.8 , pp. e59756
    • Andre, T.1    Meuleman, N.2    Stamatopoulos, B.3    De, B.C.4    Pieters, K.5    Bron, D.6    Lagneaux, L.7
  • 15
    • 70849116391 scopus 로고    scopus 로고
    • Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6
    • COI: 1:CAS:528:DC%2BD1MXhtVOrtrbF, PID: 19565371
    • Najar M, Rouas R, Raicevic G, Boufker HI, Lewalle P, Meuleman N, Bron D, Toungouz M, Martiat P, Lagneaux L (2009) Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6. Cytotherapy 11:570–583. doi:10.1080/14653240903079377
    • (2009) Cytotherapy , vol.11 , pp. 570-583
    • Najar, M.1    Rouas, R.2    Raicevic, G.3    Boufker, H.I.4    Lewalle, P.5    Meuleman, N.6    Bron, D.7    Toungouz, M.8    Martiat, P.9    Lagneaux, L.10
  • 16
    • 27944435821 scopus 로고    scopus 로고
    • Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement
    • COI: 1:STN:280:DC%2BD2MrlvF2itQ%3D%3D, PID: 16236628
    • Horwitz EM, Le BK, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A (2005) Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy 7:393–395. doi:10.1080/14653240500319234
    • (2005) Cytotherapy , vol.7 , pp. 393-395
    • Horwitz, E.M.1    Le, B.K.2    Dominici, M.3    Mueller, I.4    Slaper-Cortenbach, I.5    Marini, F.C.6    Deans, R.J.7    Krause, D.S.8    Keating, A.9
  • 17
    • 0029033142 scopus 로고
    • Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation
    • COI: 1:CAS:528:DyaK2MXns1Sms78%3D, PID: 7543921
    • Yellin MJ, Winikoff S, Fortune SM, Baum D, Crow MK, Lederman S, Chess L (1995) Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation. J Leukoc Biol 58:209–216
    • (1995) J Leukoc Biol , vol.58 , pp. 209-216
    • Yellin, M.J.1    Winikoff, S.2    Fortune, S.M.3    Baum, D.4    Crow, M.K.5    Lederman, S.6    Chess, L.7
  • 18
    • 0031297249 scopus 로고    scopus 로고
    • CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells
    • COI: 1:CAS:528:DyaK2sXnslOhsbk%3D, PID: 9548507
    • Dechanet J, Grosset C, Taupin JL, Merville P, Banchereau J, Ripoche J, Moreau JF (1997) CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells. J Immunol 159:5640–5647
    • (1997) J Immunol , vol.159 , pp. 5640-5647
    • Dechanet, J.1    Grosset, C.2    Taupin, J.L.3    Merville, P.4    Banchereau, J.5    Ripoche, J.6    Moreau, J.F.7
  • 19
    • 0038792209 scopus 로고    scopus 로고
    • CD40 and dendritic cell function
    • PID: 12906261
    • O’Sullivan B, Thomas R (2003) CD40 and dendritic cell function. Crit Rev Immunol 23:83–107
    • (2003) Crit Rev Immunol , vol.23 , pp. 83-107
    • O’Sullivan, B.1    Thomas, R.2
  • 20
    • 0035312173 scopus 로고    scopus 로고
    • Abnormalities of bone marrow mesenchymal cells in multiple myeloma patients
    • COI: 1:CAS:528:DC%2BD3MXislyhtLk%3D, PID: 11283920
    • Wallace SR, Oken MM, Lunetta KL, Panoskaltsis-Mortari A, Masellis AM (2001) Abnormalities of bone marrow mesenchymal cells in multiple myeloma patients. Cancer 91:1219–1230
    • (2001) Cancer , vol.91 , pp. 1219-1230
    • Wallace, S.R.1    Oken, M.M.2    Lunetta, K.L.3    Panoskaltsis-Mortari, A.4    Masellis, A.M.5
  • 22
    • 0026002871 scopus 로고
    • Signaling by vascular cell adhesion molecule-1 (VCAM-1) through VLA-4 promotes CD3-dependent T cell proliferation
    • COI: 1:CAS:528:DyaK38XhvFKhug%3D%3D, PID: 1718763
    • Burkly LC, Jakubowski A, Newman BM, Rosa MD, Chi-Rosso G, Lobb RR (1991) Signaling by vascular cell adhesion molecule-1 (VCAM-1) through VLA-4 promotes CD3-dependent T cell proliferation. Eur J Immunol 21:2871–2875. doi:10.1002/eji.1830211132
    • (1991) Eur J Immunol , vol.21 , pp. 2871-2875
    • Burkly, L.C.1    Jakubowski, A.2    Newman, B.M.3    Rosa, M.D.4    Chi-Rosso, G.5    Lobb, R.R.6
  • 23
    • 77951889580 scopus 로고    scopus 로고
    • Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    • COI: 1:CAS:528:DC%2BC3cXitV2ks74%3D, PID: 20130212
    • Ren G, Zhao X, Zhang L, Zhang J, L’Huillier A, Ling W, Roberts AI, Le AD, Shi S, Shao C, Shi Y (2010) Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol 184:2321–2328. doi:10.4049/jimmunol.0902023
    • (2010) J Immunol , vol.184 , pp. 2321-2328
    • Ren, G.1    Zhao, X.2    Zhang, L.3    Zhang, J.4    L’Huillier, A.5    Ling, W.6    Roberts, A.I.7    Le, A.D.8    Shi, S.9    Shao, C.10    Shi, Y.11
  • 24
    • 0035885068 scopus 로고    scopus 로고
    • Differentiation of regulatory T cells 1 is induced by CD2 costimulation
    • COI: 1:CAS:528:DC%2BD3MXmvFGitrc%3D, PID: 11544295
    • Wakkach A, Cottrez F, Groux H (2001) Differentiation of regulatory T cells 1 is induced by CD2 costimulation. J Immunol 167:3107–3113
    • (2001) J Immunol , vol.167 , pp. 3107-3113
    • Wakkach, A.1    Cottrez, F.2    Groux, H.3
  • 25
    • 36349017810 scopus 로고    scopus 로고
    • A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BD2sXhtlarurvP, PID: 17684157
    • Chabannes D, Hill M, Merieau E, Rossignol J, Brion R, Soulillou JP, Anegon I, Cuturi MC (2007) A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood 110:3691–3694. doi:10.1182/blood-2007-02-075481
    • (2007) Blood , vol.110 , pp. 3691-3694
    • Chabannes, D.1    Hill, M.2    Merieau, E.3    Rossignol, J.4    Brion, R.5    Soulillou, J.P.6    Anegon, I.7    Cuturi, M.C.8
  • 26
    • 79955971620 scopus 로고    scopus 로고
    • The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BC3MXmsVWms7w%3D, PID: 21389316
    • Mougiakakos D, Jitschin R, Johansson CC, Okita R, Kiessling R, Le BK (2011) The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells. Blood 117:4826–4835. doi:10.1182/blood-2010-12-324038
    • (2011) Blood , vol.117 , pp. 4826-4835
    • Mougiakakos, D.1    Jitschin, R.2    Johansson, C.C.3    Okita, R.4    Kiessling, R.5    Le, B.K.6
  • 27
    • 84889000385 scopus 로고    scopus 로고
    • Heme oxygenase-1 exerts a protective role in ovalbumin-induced neutrophilic airway inflammation by inhibiting Th17 cell-mediated immune response
    • COI: 1:CAS:528:DC%2BC3sXhvVKntrzM, PID: 24097973
    • Zhang Y, Zhang L, Wu J, Di C, Xia Z (2013) Heme oxygenase-1 exerts a protective role in ovalbumin-induced neutrophilic airway inflammation by inhibiting Th17 cell-mediated immune response. J Biol Chem 288:34612–34626. doi:10.1074/jbc.M113.494369
    • (2013) J Biol Chem , vol.288 , pp. 34612-34626
    • Zhang, Y.1    Zhang, L.2    Wu, J.3    Di, C.4    Xia, Z.5
  • 28
    • 33745076513 scopus 로고    scopus 로고
    • Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma
    • COI: 1:CAS:528:DC%2BD28XlvFCgt74%3D, PID: 16493000
    • Chan JL, Tang KC, Patel AP, Bonilla LM, Pierobon N, Ponzio NM, Rameshwar P (2006) Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood 107:4817–4824. doi:10.1182/blood-2006-01-0057
    • (2006) Blood , vol.107 , pp. 4817-4824
    • Chan, J.L.1    Tang, K.C.2    Patel, A.P.3    Bonilla, L.M.4    Pierobon, N.5    Ponzio, N.M.6    Rameshwar, P.7
  • 29
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • COI: 1:CAS:528:DC%2BD28XksVGns7g%3D, PID: 16648838
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235–238. doi:10.1038/nature04753
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 30
    • 34347371299 scopus 로고    scopus 로고
    • Identification of IL-10 and TGF-beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenchymal stem cells
    • PID: 17605296
    • Nasef A, Chapel A, Mazurier C, Bouchet S, Lopez M, Mathieu N, Sensebe L, Zhang Y, Gorin NC, Thierry D, Fouillard L (2007) Identification of IL-10 and TGF-beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenchymal stem cells. Gene Expr 13:217–226
    • (2007) Gene Expr , vol.13 , pp. 217-226
    • Nasef, A.1    Chapel, A.2    Mazurier, C.3    Bouchet, S.4    Lopez, M.5    Mathieu, N.6    Sensebe, L.7    Zhang, Y.8    Gorin, N.C.9    Thierry, D.10    Fouillard, L.11
  • 31
    • 0027281346 scopus 로고
    • Human interleukin-10 can directly inhibit T-cell growth
    • COI: 1:CAS:528:DyaK3sXkvFegtL4%3D, PID: 8499633
    • Taga K, Mostowski H, Tosato G (1993) Human interleukin-10 can directly inhibit T-cell growth. Blood 81:2964–2971
    • (1993) Blood , vol.81 , pp. 2964-2971
    • Taga, K.1    Mostowski, H.2    Tosato, G.3
  • 33
    • 34247895422 scopus 로고    scopus 로고
    • Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17
    • COI: 1:CAS:528:DC%2BD2sXlsVWnu74%3D, PID: 17307864
    • Nakae S, Iwakura Y, Suto H, Galli SJ (2007) Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol 81:1258–1268. doi:10.1189/jlb.1006610
    • (2007) J Leukoc Biol , vol.81 , pp. 1258-1268
    • Nakae, S.1    Iwakura, Y.2    Suto, H.3    Galli, S.J.4
  • 34
    • 84880032316 scopus 로고    scopus 로고
    • Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy
    • COI: 1:CAS:528:DC%2BC3sXhtVKrs7fI, PID: 23607751
    • Cipriani P, Di BP, Liakouli V, Del PB, Di PM, Di IM, Marrelli A, Alesse E, Giacomelli R (2013) Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy. Clin Exp Immunol 173:195–206. doi:10.1111/cei.12111
    • (2013) Clin Exp Immunol , vol.173 , pp. 195-206
    • Cipriani, P.1    Di, B.P.2    Liakouli, V.3    Del, P.B.4    Di, P.M.5    Di, I.M.6    Marrelli, A.7    Alesse, E.8    Giacomelli, R.9
  • 35
    • 80052334231 scopus 로고    scopus 로고
    • The suppressive effect of mesenchymal stromal cells on T cell proliferation is conserved in old age
    • COI: 1:CAS:528:DC%2BC3MXhtFahtr3L, PID: 21726642
    • Landgraf K, Brunauer R, Lepperdinger G, Grubeck-Loebenstein B (2011) The suppressive effect of mesenchymal stromal cells on T cell proliferation is conserved in old age. Transpl Immunol 25:167–172. doi:10.1016/j.trim.2011.06.007
    • (2011) Transpl Immunol , vol.25 , pp. 167-172
    • Landgraf, K.1    Brunauer, R.2    Lepperdinger, G.3    Grubeck-Loebenstein, B.4
  • 36
    • 3042614161 scopus 로고    scopus 로고
    • The CD40/CD40L costimulatory pathway in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD2cXlvFemt70%3D, PID: 15194658
    • Danese S, Sans M, Fiocchi C (2004) The CD40/CD40L costimulatory pathway in inflammatory bowel disease. Gut 53:1035–1043
    • (2004) Gut , vol.53 , pp. 1035-1043
    • Danese, S.1    Sans, M.2    Fiocchi, C.3
  • 37
    • 0025999635 scopus 로고
    • Detection of hyperreactive T cells in multiple myeloma by multivalent cross-linking of the CD3/TCR complex
    • COI: 1:STN:280:DyaK38%2Fgtl2iug%3D%3D, PID: 1832993
    • Massaia M, Bianchi A, Attisano C, Peola S, Redoglia V, Dianzani U, Pileri A (1991) Detection of hyperreactive T cells in multiple myeloma by multivalent cross-linking of the CD3/TCR complex. Blood 78:1770–1780
    • (1991) Blood , vol.78 , pp. 1770-1780
    • Massaia, M.1    Bianchi, A.2    Attisano, C.3    Peola, S.4    Redoglia, V.5    Dianzani, U.6    Pileri, A.7
  • 38
    • 0028936861 scopus 로고
    • CD40 ligand triggered interleukin-6 secretion in multiple myeloma
    • COI: 1:CAS:528:DyaK2MXkslSjtb8%3D, PID: 7535594
    • Urashima M, Chauhan D, Uchiyama H, Freeman GJ, Anderson KC (1995) CD40 ligand triggered interleukin-6 secretion in multiple myeloma. Blood 85:1903–1912
    • (1995) Blood , vol.85 , pp. 1903-1912
    • Urashima, M.1    Chauhan, D.2    Uchiyama, H.3    Freeman, G.J.4    Anderson, K.C.5
  • 39
    • 0141953292 scopus 로고    scopus 로고
    • Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells
    • COI: 1:CAS:528:DC%2BD3sXotV2jtbg%3D, PID: 14559800
    • Chauhan D, Li G, Shringarpure R, Podar K, Ohtake Y, Hideshima T, Anderson KC (2003) Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res 63:6174–6177
    • (2003) Cancer Res , vol.63 , pp. 6174-6177
    • Chauhan, D.1    Li, G.2    Shringarpure, R.3    Podar, K.4    Ohtake, Y.5    Hideshima, T.6    Anderson, K.C.7
  • 40
    • 0042346066 scopus 로고    scopus 로고
    • Proangiogenic function of CD40 ligand-CD40 interactions
    • COI: 1:CAS:528:DC%2BD3sXlsFylur0%3D, PID: 12874247
    • Reinders ME, Sho M, Robertson SW, Geehan CS, Briscoe DM (2003) Proangiogenic function of CD40 ligand-CD40 interactions. J Immunol 171:1534–1541
    • (2003) J Immunol , vol.171 , pp. 1534-1541
    • Reinders, M.E.1    Sho, M.2    Robertson, S.W.3    Geehan, C.S.4    Briscoe, D.M.5
  • 41
    • 0031015589 scopus 로고    scopus 로고
    • Expression of the cell-adhesion molecule VCAM-1 by stromal cells is necessary for osteoclastogenesis
    • COI: 1:CAS:528:DyaK2sXptlShsg%3D%3D, PID: 9013850
    • Feuerbach D, Feyen JH (1997) Expression of the cell-adhesion molecule VCAM-1 by stromal cells is necessary for osteoclastogenesis. FEBS Lett 402:21–24. doi:10.1016/S0014-5793(96)01495-0
    • (1997) FEBS Lett , vol.402 , pp. 21-24
    • Feuerbach, D.1    Feyen, J.H.2
  • 42
    • 34447120196 scopus 로고    scopus 로고
    • The role of vascular cell adhesion molecule-1 in tumor immune evasion
    • COI: 1:CAS:528:DC%2BD2sXnsVyqsLw%3D, PID: 17616653
    • Wu TC (2007) The role of vascular cell adhesion molecule-1 in tumor immune evasion. Cancer Res 67:6003–6006. doi:10.1158/0008-5472.CAN-07-1543
    • (2007) Cancer Res , vol.67 , pp. 6003-6006
    • Wu, T.C.1
  • 43
    • 0038369758 scopus 로고    scopus 로고
    • Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-kappa B (RelB/p50) in myeloma cells
    • COI: 1:CAS:528:DC%2BD3sXjt1als7s%3D, PID: 12717418
    • Landowski TH, Olashaw NE, Agrawal D, Dalton WS (2003) Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-kappa B (RelB/p50) in myeloma cells. Oncogene 22:2417–2421. doi:10.1038/sj.onc.1206315
    • (2003) Oncogene , vol.22 , pp. 2417-2421
    • Landowski, T.H.1    Olashaw, N.E.2    Agrawal, D.3    Dalton, W.S.4
  • 44
    • 53449089919 scopus 로고    scopus 로고
    • Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
    • COI: 1:CAS:528:DC%2BD1cXht1SrtbzM, PID: 18669891
    • Dhodapkar KM, Barbuto S, Matthews P, Kukreja A, Mazumder A, Vesole D, Jagannath S, Dhodapkar MV (2008) Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 112:2878–2885. doi:10.1182/blood-2008-03-143222
    • (2008) Blood , vol.112 , pp. 2878-2885
    • Dhodapkar, K.M.1    Barbuto, S.2    Matthews, P.3    Kukreja, A.4    Mazumder, A.5    Vesole, D.6    Jagannath, S.7    Dhodapkar, M.V.8
  • 45
    • 78149322663 scopus 로고    scopus 로고
    • A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma
    • COI: 1:CAS:528:DC%2BC3cXhsVKksb7E, PID: 20664052
    • Noonan K, Marchionni L, Anderson J, Pardoll D, Roodman GD, Borrello I (2010) A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. Blood 116:3554–3563. doi:10.1182/blood-2010-05-283895
    • (2010) Blood , vol.116 , pp. 3554-3563
    • Noonan, K.1    Marchionni, L.2    Anderson, J.3    Pardoll, D.4    Roodman, G.D.5    Borrello, I.6
  • 46
    • 84885350915 scopus 로고    scopus 로고
    • Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance
    • COI: 1:STN:280:DC%2BC3sbosFeqtQ%3D%3D, PID: 24036947
    • Bryant C, Suen H, Brown R, Yang S, Favaloro J, Aklilu E, Gibson J, Ho PJ, Iland H, Fromm P, Woodland N, Nassif N, Hart D, Joshua DE (2013) Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance. Blood Cancer J 3:e148. doi:10.1038/bcj.2013.34
    • (2013) Blood Cancer J , vol.3 , pp. e148
    • Bryant, C.1    Suen, H.2    Brown, R.3    Yang, S.4    Favaloro, J.5    Aklilu, E.6    Gibson, J.7    Ho, P.J.8    Iland, H.9    Fromm, P.10    Woodland, N.11    Nassif, N.12    Hart, D.13    Joshua, D.E.14
  • 47
    • 0035958517 scopus 로고    scopus 로고
    • The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications
    • COI: 1:CAS:528:DC%2BD3MXlvVGktr4%3D, PID: 11494147
    • Hideshima T, Chauhan D, Schlossman R, Richardson P, Anderson KC (2001) The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene 20:4519–4527. doi:10.1038/sj.onc.1204623
    • (2001) Oncogene , vol.20 , pp. 4519-4527
    • Hideshima, T.1    Chauhan, D.2    Schlossman, R.3    Richardson, P.4    Anderson, K.C.5
  • 48
    • 10344264979 scopus 로고    scopus 로고
    • Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner
    • COI: 1:CAS:528:DC%2BD2cXhtVOntbzK, PID: 15598423
    • Payvandi F, Wu L, Haley M, Schafer PH, Zhang LH, Chen RS, Muller GW, Stirling DI (2004) Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cell Immunol 230:81–88. doi:10.1016/j.cellimm.2004.09.003
    • (2004) Cell Immunol , vol.230 , pp. 81-88
    • Payvandi, F.1    Wu, L.2    Haley, M.3    Schafer, P.H.4    Zhang, L.H.5    Chen, R.S.6    Muller, G.W.7    Stirling, D.I.8
  • 49
    • 84857770908 scopus 로고    scopus 로고
    • Lenalidomide-induced immunomodulation in multiple myeloma: impact on vaccines and antitumor responses
    • COI: 1:CAS:528:DC%2BC38Xjt1Wlu70%3D, PID: 22241792
    • Noonan K, Rudraraju L, Ferguson A, Emerling A, Pasetti MF, Huff CA, Borrello I (2012) Lenalidomide-induced immunomodulation in multiple myeloma: impact on vaccines and antitumor responses. Clin Cancer Res 18:1426–1434. doi:10.1158/1078-0432.CCR-11-1221
    • (2012) Clin Cancer Res , vol.18 , pp. 1426-1434
    • Noonan, K.1    Rudraraju, L.2    Ferguson, A.3    Emerling, A.4    Pasetti, M.F.5    Huff, C.A.6    Borrello, I.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.