A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities

Chemistry and Biology

Volumn 22, Issue 3, 2015, Pages 391-403

  Ko, Sung Kyun ^a,e   Kim, Jiyeon ^a   Na, Deuk Chae ^b   Park, Sookil ^a   Park, Seong Hyun ^a   Hyun, Ji Young ^a   Baek, Kyung Hwa ^a   Kim, Nam Doo ^c   Kim, Nak Kyoon ^d   Park, Young Nyun ^b   Song, Kiwon ^a   Shin, Injae ^a  

^a Yonsei University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

^e Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; APOPTOZOLE; CASPASE; CHAPERONIN 60; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; UNCLASSIFIED DRUG; ENZYME INHIBITOR; HEAT SHOCK PROTEIN 70L1, HUMAN; IMIDAZOLE DERIVATIVE; PROTEIN BINDING;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; HELA CELL LINE; HEPG2 CELL LINE; MALE; METABOLISM; NEOPLASMS; NUDE MOUSE; PATHOLOGY; RANDOMIZATION; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; ENZYME INHIBITORS; HELA CELLS; HEP G2 CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMIDAZOLES; MALE; MICE; MICE, NUDE; NEOPLASMS; PROTEIN BINDING; RANDOM ALLOCATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84925463299     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.02.004     Document Type: Article

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