Copper-mediated construction of spirocyclic bis-oxindoles via a double C-H, Ar-H coupling process

Organic Letters

Volumn 16, Issue 18, 2014, Pages 4900-4903

  Drouhin, Pauline ^a   Hurst, Timothy E ^a   Whitwood, Adrian C ^a   Taylor, Richard J K ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84925454818     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol5024129     Document Type: Article

References (41)

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37. X-ray data for 4a have been deposited with the Cambridge Crystallographic Data Centre (CCDC 1013303), which can be obtained free of charge via www.ccdc.cam.ac.uk/data-request/cif.
38. X-ray data for 5a have been deposited with the Cambridge Crystallographic Data Centre (CCDC 1004040), which can be obtained free of charge via www.ccdc.cam.ac.uk/data-request/cif.
39. The cyclopentanone precursors were prepared using the procedure described for 4a; the 6- and 7-membered ring precursors 4g-j were synthesized from cyclohexanone or -heptanone via double carboxylation with methyl magnesiumcarbonate: Stiles, M. J. Am. Chem. Soc. 1959, 81, 2598. This was followed by double Mukaiyama amide coupling (see Supporting Information for details).
40. X-ray data for cis- and trans-10 have been deposited with the Cambridge Crystallographic Data Centre (CCDC 1004041 and 1016758), which can be obtained free of charge via www.ccdc.cam. ac.uk/data-request/cif.
41. X-ray data for meso-12a and dl-12a have been deposited with the Cambridge Crystallographic Data Centre (meso-12a: CCDC 1013389, DL-12a: CCDC 1013390), which can be obtained free of charge via www.ccdc.cam.ac.uk/data-request/cif. See Supporting Information for crystallographic details.