Total synthesis of (+)-11/11'-Dideoxyverticillin A

Science

Volumn 324, Issue 5924, 2009, Pages 238-241

  Kim, Justin ^a   Ashenhurst, James A ^a   Movassaghi, Mohammad ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11,11' DIDEOXYVERTICILLIN A; ALKALOID DERIVATIVE; UNCLASSIFIED DRUG;

ALKALOID; ANTIBIOTICS; BIOTECHNOLOGY; CHEMICAL REACTION; FUNGUS; MARINE RESOURCE; MARINE TECHNOLOGY; METABOLITE;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; PENICILLIUM; PRIORITY JOURNAL; STEREOCHEMISTRY;

ALKALOIDS; DIMERIZATION; DISULFIDES; HYDROXYLATION; MOLECULAR STRUCTURE; PENICILLIUM; PIPERAZINES; STEREOISOMERISM;

PENICILLIUM SP.;

EID: 64849113664     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1170777     Document Type: Article

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37. M.M. is an Alfred P. Sloan Research Fellow and a Beckman Young Investigator. J.K. and J.A.A. acknowledge predoctoral (National Defense Science and Engineering Graduate) and postdoctoral [Fonds québécois de la recherche sur la nature et les technologies (FQRNT)] fellowships, respectively. We thank P. Müller for assistance with x-ray structures of (+)-1 and (+)-14. We acknowledge generous support from Amgen, AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Merck, and Lilly. Structural parameters for and (+)-14 are freely available from the Cambridge Crystallographic Data Centre under CCDC-719219 and CCDC-719218, respectively.