메뉴 건너뛰기




Volumn 753, Issue , 2015, Pages 135-139

The genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains

Author keywords

Behavior; Drug targets; Endophenotypes; Human; Mouse; Psychiatry

Indexed keywords

ARTICLE; BIPOLAR DISORDER; CENTRAL NERVOUS SYSTEM; DNA METHYLATION; DNA MODIFICATION; DRUG RESEARCH; DRUG TARGETING; ENDOPHENOTYPE; EPIGENETICS; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC REGULATION; GENETIC VARIABILITY; HUMAN; MAJOR DEPRESSION; MENTAL DISEASE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSGENIC ANIMAL; ANIMAL; DISEASE MODEL; DRUG DEVELOPMENT; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; MENTAL DISORDERS; PROCEDURES;

EID: 84925434860     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.07.043     Document Type: Article
Times cited : (4)

References (48)
  • 2
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • S.L. Berger The complex language of chromatin regulation during transcription Nature 447 2007 407 412
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 4
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • A. Bird Perceptions of epigenetics Nature 447 2007 396 398
    • (2007) Nature , vol.447 , pp. 396-398
    • Bird, A.1
  • 5
    • 84891788593 scopus 로고    scopus 로고
    • The Mouse Genome Database: Integration of and access to knowledge about the laboratory mouse
    • Mouse Genome Database,G
    • J.A. Blake, C.J. Bult, J.T. Eppig, J.A. Kadin, J.E. Richardson Mouse Genome Database,G The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse Nucleic Acids Res. 42 2014 D810 D817
    • (2014) Nucleic Acids Res. , vol.42 , pp. D810-D817
    • Blake, J.A.1    Bult, C.J.2    Eppig, J.T.3    Kadin, J.A.4    Richardson, J.E.5
  • 7
    • 78649906686 scopus 로고    scopus 로고
    • Eating disorders, gene-environment interactions and epigenetics
    • I.C. Campbell, J. Mill, R. Uher, and U. Schmidt Eating disorders, gene-environment interactions and epigenetics Neurosci. Biobehav. Rev. 35 2011 784 793
    • (2011) Neurosci. Biobehav. Rev. , vol.35 , pp. 784-793
    • Campbell, I.C.1    Mill, J.2    Uher, R.3    Schmidt, U.4
  • 8
    • 77954855829 scopus 로고    scopus 로고
    • Non-coding RNAs: Meet thy masters
    • F.F. Costa Non-coding RNAs: meet thy masters Bioessays 32 2010 599 608
    • (2010) Bioessays , vol.32 , pp. 599-608
    • Costa, F.F.1
  • 9
    • 59349084681 scopus 로고    scopus 로고
    • Genetics of bipolar disorder: Successful start to a long journey
    • N. Craddock, and P. Sklar Genetics of bipolar disorder: successful start to a long journey Trends Genet. 25 2009 99 105
    • (2009) Trends Genet. , vol.25 , pp. 99-105
    • Craddock, N.1    Sklar, P.2
  • 10
    • 84877704720 scopus 로고    scopus 로고
    • Genetics of bipolar disorder
    • N. Craddock, and P. Sklar Genetics of bipolar disorder Lancet 381 2013 1654 1662
    • (2013) Lancet , vol.381 , pp. 1654-1662
    • Craddock, N.1    Sklar, P.2
  • 12
    • 43049144601 scopus 로고    scopus 로고
    • Behavioural genetics in mood and anxiety: A next step in finding novel pharmacological targets
    • A.J. De Mooij-van Malsen, B. Olivier, and M.J. Kas Behavioural genetics in mood and anxiety: a next step in finding novel pharmacological targets Eur. J. Pharmacol. 585 2008 436 440
    • (2008) Eur. J. Pharmacol. , vol.585 , pp. 436-440
    • De Mooij-Van Malsen, A.J.1    Olivier, B.2    Kas, M.J.3
  • 16
    • 84871826835 scopus 로고    scopus 로고
    • Epigenetic studies of schizophrenia: Progress, predicaments, and promises for the future
    • E. Dempster, J. Viana, R. Pidsley, and J. Mill Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future Schizophr. Bull. 39 2013 11 16
    • (2013) Schizophr. Bull. , vol.39 , pp. 11-16
    • Dempster, E.1    Viana, J.2    Pidsley, R.3    Mill, J.4
  • 17
    • 79954537130 scopus 로고    scopus 로고
    • Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus
    • H. Funato, S. Oda, J. Yokofujita, H. Igarashi, and M. Kuroda Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus PLoS One 6 2011 e18950
    • (2011) PLoS One , vol.6 , pp. e18950
    • Funato, H.1    Oda, S.2    Yokofujita, J.3    Igarashi, H.4    Kuroda, M.5
  • 20
    • 33847304609 scopus 로고    scopus 로고
    • Gene body-specific methylation on the active X chromosome
    • A. Hellman, and A. Chess Gene body-specific methylation on the active X chromosome Science 315 2007 1141 1143
    • (2007) Science , vol.315 , pp. 1141-1143
    • Hellman, A.1    Chess, A.2
  • 21
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing c.
    • International Human Genome Sequencing,C. Finishing the euchromatic sequence of the human genome Nature 431 2004 931 945
    • (2004) Nature , vol.431 , pp. 931-945
  • 23
    • 33947623162 scopus 로고    scopus 로고
    • Genetics of behavioural domains across the neuropsychiatric spectrum; Of mice and men
    • M.J. Kas, C. Fernandes, L.C. Schalkwyk, and D.A. Collier Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men Mol. Psychiatry 12 2007 324 330
    • (2007) Mol. Psychiatry , vol.12 , pp. 324-330
    • Kas, M.J.1    Fernandes, C.2    Schalkwyk, L.C.3    Collier, D.A.4
  • 26
    • 84876738099 scopus 로고    scopus 로고
    • Epigenetic dynamics in psychiatric disorders: Environmental programming of neurodevelopmental processes
    • D. Kofink, M.P. Boks, H.T. Timmers, and M.J. Kas Epigenetic dynamics in psychiatric disorders: environmental programming of neurodevelopmental processes Neurosci. Biobehav. Rev. 37 2013 831 845
    • (2013) Neurosci. Biobehav. Rev. , vol.37 , pp. 831-845
    • Kofink, D.1    Boks, M.P.2    Timmers, H.T.3    Kas, M.J.4
  • 31
    • 84867709301 scopus 로고    scopus 로고
    • Epigenetics, depression and antidepressant treatment
    • A. Menke, T. Klengel, and E.B. Binder Epigenetics, depression and antidepressant treatment Curr. Pharm. Des. 18 2012 5879 5889
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 5879-5889
    • Menke, A.1    Klengel, T.2    Binder, E.B.3
  • 32
    • 0024809166 scopus 로고
    • Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes
    • K.A. Miczek, J. Mos, and B. Olivier Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes Psychopharmacol. Bull. 25 1989 399 403
    • (1989) Psychopharmacol. Bull. , vol.25 , pp. 399-403
    • Miczek, K.A.1    Mos, J.2    Olivier, B.3
  • 33
    • 84884325266 scopus 로고    scopus 로고
    • Dissecting quantitative traits in mice. Annual review of genomics and human genetics
    • R. Mott, and J. Flint Dissecting quantitative traits in mice. Annual review of genomics and human genetics Annu. Rev. Genomics Hum. Genet. 14 2013 421 439
    • (2013) Annu. Rev. Genomics Hum. Genet. , vol.14 , pp. 421-439
    • Mott, R.1    Flint, J.2
  • 35
    • 0019519416 scopus 로고
    • Selective anti-aggressive properties of du 27725: Ethological analyses of intermale and territorial aggression in the male rat
    • B. Olivier Selective anti-aggressive properties of DU 27725: ethological analyses of intermale and territorial aggression in the male rat Pharmacol. Biochem. Behav. 14 1 1981 61 77
    • (1981) Pharmacol. Biochem. Behav. , vol.14 , Issue.1 , pp. 61-77
    • Olivier, B.1
  • 36
    • 0025001633 scopus 로고
    • Ethopharmacology: A creative approach to identification and characterisation of novel psychotropics
    • B. Olivier, D. Rasmussen, M. Raghoebar, and J. Mos Ethopharmacology: a creative approach to identification and characterisation of novel psychotropics Drug Metabol. Drug Interact. 8 1990 11 29
    • (1990) Drug Metabol. Drug Interact. , vol.8 , pp. 11-29
    • Olivier, B.1    Rasmussen, D.2    Raghoebar, M.3    Mos, J.4
  • 37
    • 78650429158 scopus 로고    scopus 로고
    • Epigenetic studies of psychosis: Current findings, methodological approaches, and implications for postmortem research
    • R. Pidsley, and J. Mill Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research Biol. Psychiatry 69 2011 146 156
    • (2011) Biol. Psychiatry , vol.69 , pp. 146-156
    • Pidsley, R.1    Mill, J.2
  • 39
    • 80053385384 scopus 로고    scopus 로고
    • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
    • Psychiatric Genetics Consortium Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 Nature Genet. 43 2011 977 983
    • (2011) Nature Genet. , vol.43 , pp. 977-983
    • Genetics Consortium, P.1
  • 41
    • 84870546598 scopus 로고    scopus 로고
    • Human disease: Strength to strength for mouse models
    • K. Schughart, C. Libert, and M.J. Kas Human disease: strength to strength for mouse models Nature 492 2012 41
    • (2012) Nature , vol.492 , pp. 41
    • Schughart, K.1    Libert, C.2    Kas, M.J.3
  • 42
    • 0343673926 scopus 로고    scopus 로고
    • Dissection of behavior and psychiatric disorders using the mouse as a model
    • L.M. Tarantino, and M. Bucan Dissection of behavior and psychiatric disorders using the mouse as a model Hum. Mol. Genet. 9 2000 953 965
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 953-965
    • Tarantino, L.M.1    Bucan, M.2
  • 43
    • 78751689075 scopus 로고    scopus 로고
    • Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events
    • S. Uchida, K. Hara, A. Kobayashi, K. Otsuki, H. Yamagata, T. Hobara, T. Suzuki, N. Miyata, and Y. Watanabe Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events Neuron 69 2011 359 372
    • (2011) Neuron , vol.69 , pp. 359-372
    • Uchida, S.1    Hara, K.2    Kobayashi, A.3    Otsuki, K.4    Yamagata, H.5    Hobara, T.6    Suzuki, T.7    Miyata, N.8    Watanabe, Y.9
  • 45
    • 79954573165 scopus 로고    scopus 로고
    • Chronic high-fat diet drives postnatal epigenetic regulation of mu-opioid receptor in the brain
    • Z. Vucetic, J. Kimmel, and T.M. Reyes Chronic high-fat diet drives postnatal epigenetic regulation of mu-opioid receptor in the brain Neuropsychopharmacology 36 2011 1199 1206
    • (2011) Neuropsychopharmacology , vol.36 , pp. 1199-1206
    • Vucetic, Z.1    Kimmel, J.2    Reyes, T.M.3
  • 47
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 7145 2007 661 678
    • (2007) Nature , vol.447 , Issue.7145 , pp. 661-678
  • 48
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • V.W. Zhou, A. Goren, and B.E. Bernstein Charting histone modifications and the functional organization of mammalian genomes Nat. Rev. Genet. 12 2011 7 18
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.