Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition

International Journal of Oncology

Volumn 46, Issue 5, 2015, Pages 2205-2215

  Zhao, Tengda ^a   Hu, Fengchun ^a   Qiao, Bin ^b   Chen, Zhifeng ^c   Tao, Qian ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition; Human oral epithelial cells; Oral squamous cell carcinoma; Progression; Telomerase reverse transcriptase

Indexed keywords

BETA CATENIN; TELOMERASE REVERSE TRANSCRIPTASE; WNT PROTEIN; SMALL INTERFERING RNA; TELOMERASE; TERT PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM DYSPLASIA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MIDDLE AGED; MOUTH SQUAMOUS CELL CARCINOMA; ORAL EPITHELIAL DYSPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR INVASION; UPREGULATION; CONFOCAL MICROSCOPY; DISEASE COURSE; ENZYMOLOGY; GENETIC TRANSFECTION; HEAD AND NECK TUMOR; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUTH TUMOR; PATHOLOGY; PHYSIOLOGY; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; MOUTH NEOPLASMS; RNA, SMALL INTERFERING; TELOMERASE; TRANSFECTION;

EID: 84925433268     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.2927     Document Type: Article

References (37)

1. Bray F, Sankila R, Ferlay J and Parkin DM: Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer 38: 99-166, 2002.
2. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
3. Liu JP, Chen SM, Cong YS, Nicholls C, Zhou SF, Tao ZZ and Li H: Regulation of telomerase activity by apparently opposing elements. Ageing Res Rev 9: 245-256, 2010.
4. Shay JW and Wright WE: Hallmarks of telomeres in ageing research. J Pathol 211: 114-123, 2007.
5. Kapanadze B, Morris E, Smith E and Trojanowska M: Establishment and characterization of scleroderma fibroblast clonal cell lines by introduction of the hTERT gene. J Cell Mol Med 14: 1156-1165, 2010.
6. Wieser M, Stadler G, Jennings P, Streubel B, Pfaller W, Ambros P, Riedl C, Katinger H, Grillari J and Grillari-Voglauer R: hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics. Am J Physiol Renal Physiol 295: F1365-F1375, 2008.
7. Stewart SA, Hahn WC, O'Connor BF, et al: Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci USA 99: 12606-12611, 2002.
8. Smith LL, Coller HA and Roberts JM: Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 5: 474-479, 2003.
9. Yang C, Przyborski S, Cooke MJ, Zhang X, Stewart R, Anyfantis G, Atkinson SP, Saretzki G, Armstrong L and Lako M: A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation. Stem Cells 26: 850-863, 2008.
10. Lee J, Sung YH, Cheong C, Choi YS, Jeon HK, Sun W, Hahn WC, Ishikawa F and Lee HW: TERT promotes cellular and organismal survival independently of telomerase activity. Oncogene 27: 3754-3760, 2008.
11. Bertorelle R, Briarava M, Rampazzo E, et al: Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer. Br J Cancer 108: 278-284, 2013.
12. Eid MM, Helmy NA, Omar IM, Mohamed AA, El Sewefy D, Fadel IM and Helal RA: Clinical significance of telomerase genes (hTERC and hTERT) amplification in patients with acute myeloid leukemia. Gulf J Oncol 1: 51-60, 2013.
13. Lötsch D, Ghanim B, Laaber M, Wurm G, Weis S, Lenz S, Webersinke G, Pichler J, Berger W and Spiegl-Kreinecker S: Prognostic significance of telomerase-associated parameters in glioblastoma: Effect of patient age. Neuro-oncol 15: 423-432, 2013.
14. Nakashima A, Murakami Y, Uemura K, Hayashidani Y, Sudo T, Hashimoto Y, Ohge H, Oda M, Sueda T and Hiyama E: Usefulness of human telomerase reverse transcriptase in pancreatic juice as a biomarker of pancreatic malignancy. Pancreas 38: 527-533, 2009.
15. Tsuji T, Ibaragi S and Hu GF: Epithelial-mesenchymal transition and cell cooperativity in metastasis. Cancer Res 69: 7135-7139, 2009.
16. Liu Z, Li Q, Li K, et al: Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells. Oncogene 32: 4203-4213, 2013.
17. Gröger S, Michel J and Meyle J: Establishment and characterization of immortalized human gingival keratinocyte cell lines. J Periodontal Res 43: 604-614, 2008.
18. Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricala C and O'Toole KM: A two-stage, p16 (INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol 22: 5157-5172, 2002.
19. Dissanayake SK, Wade M, Johnson CE, et al: The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem 282: 17259-17271, 2007.
20. Park JI, Venteicher AS, Hong JY, et al: Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460: 66-72, 2009.
21. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin 58: 71-96, 2008.
22. Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
23. Prieur A and Peeper DS: Cellular senescence in vivo: A barrier to tumorigenesis. Curr Opin Cell Biol 20: 150-155, 2008.
24. Pelosi G, Schianchi E, Dell'orto P, Veronesi G, Spaggiari L, Pasini F, Sozzi G, Brambilla E, Griso C and Viale G: Detecting cell-free circulating hTERT mRNA in the plasma may identify a subset of nonsmall cell lung cancer patients. Virchows Arch 448: 7-15, 2006.
25. Gigek CO, Leal MF, Silva PNO, Lisboa LC, Lima EM, Calcagno DQ, Assumpc¸ão PP, Burbano RR and Smith MA: hTERT methylation and expression in gastric cancer. Biomarkers 14: 630-636, 2009.
26. Saini N, Srinivasan R, Chawla Y, Sharma S, Chakraborti A and Rajwanshi A: Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status. Liver Int 29: 1162-1170, 2009.
27. Divella R, Tommasi S, Lacalamita R, et al: Circulating hTERT DNA in early breast cancer. Anticancer Res 29: 2845-2849, 2009.
28. Capkova L, Kalinova M, Krskova L, Kodetova D, Petrik F, Trefny M, Musil J and Kodet R: Loss of heterozygosity and human telomerase reverse transcriptase (hTERT) expression in bronchial mucosa of heavy smokers. Cancer 109: 2299-2307, 2007.
29. Pucciarelli S, Rampazzo E, Briarava M, et al: Telomere-specific reverse transcriptase (hTERT) and cell-free RNA in plasma as predictors of pathologic tumor response in rectal cancer patients receiving neoadjuvant chemoradiotherapy. Ann Surg Oncol 19: 3089-3096, 2012.
30. Sasaki T, Kuniyasu H, Luo Y, Kitayoshi M, Tanabe E, Kato D, Shinya S, Fujii K, Ohmori H and Yamashita Y: AKT activation and telomerase reverse transcriptase expression are concurrently associated with prognosis of gastric cancer. Pathobiology 81: 36-41, 2014.
31. Chang L, Graham PH, Hao J, Ni J, Bucci J, Cozzi PJ, Kearsley JH and Li Y: Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Cell Death Dis 4: e875, 2013.
32. Li NY, Weber CE, Wai PY, Cuevas BD, Zhang J, Kuo PC and Mi Z: An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines. Surgery 154: 404-410, 2013.
33. Kypta RM and Waxman J: Wnt/beta-catenin signalling in prostate cancer. Nat Rev Urol 9: 418-428, 2012.
34. Kahlert UD, Maciaczyk D, Doostkam S, et al: Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition. Cancer Lett 325: 42-53, 2012.
35. Bertrand FE, McCubrey JA, Angus CW, Nutter JM and Sigounas G: NOTCH and PTEN in prostate cancer. Adv Biol Regul 56: 51-65, 2014.
36. Cichon MA and Radisky DC: ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail. Oncotarget 5: 2827-2838, 2014.
37. Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del Valle I, Hein K, Vogt R and Kemler R: Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336: 1549-1554, 2012.