Selective inhibition of deactivated mitochondrial complex i by biguanides

Biochemistry

Volumn 54, Issue 11, 2015, Pages 2011-2021

  Matsuzaki, Satoshi ^a   Humphries, Kenneth M ^a,b,c  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINITY; ELECTRON TRANSPORT PROPERTIES; FLAVONOIDS; FREE RADICALS; OXYGEN; RATS;

ANTIHYPERGLYCEMIC AGENT; CONFORMATIONAL STATE; FREE RADICAL PRODUCTIONS; MITOCHONDRIAL COMPLEX; MITOCHONDRIAL ELECTRON TRANSPORT CHAIN; RELATIVE SENSITIVITY; SELECTIVE INHIBITION; SUPEROXIDE PRODUCTION;

MITOCHONDRIA;

BIGUANIDE DERIVATIVE; CYTOCHROME C OXIDASE; METFORMIN; OXYGEN; PHENFORMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; SUPEROXIDE DISMUTASE; UBIQUINOL CYTOCHROME C REDUCTASE; ANTIDIABETIC AGENT; ENZYME INHIBITOR; MAGNESIUM CHLORIDE; SUPEROXIDE;

ALKALINITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME REACTIVATION; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; IN VIVO STUDY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; SENSITIVITY ANALYSIS; SPIN TRAPPING; SUBMITOCHONDRIAL PARTICLE; ANIMAL; ANTAGONISTS AND INHIBITORS; CARDIAC MUSCLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; ELECTRON SPIN RESONANCE; ENZYMOLOGY; HEART; IN VITRO STUDY; ISCHEMIA; KINETICS; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTRON TRANSPORT COMPLEX I; ENZYME INHIBITORS; HEART; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; IN VITRO TECHNIQUES; ISCHEMIA; KINETICS; MAGNESIUM CHLORIDE; MALE; METFORMIN; MITOCHONDRIA, HEART; MODELS, MOLECULAR; MYOCARDIUM; PHENFORMIN; RATS, SPRAGUE-DAWLEY; SUBMITOCHONDRIAL PARTICLES; SUPEROXIDES;

EID: 84925432968     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501473h     Document Type: Article

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