An overview of the metabolic functions of osteocalcin

Reviews in Endocrine and Metabolic Disorders

Volumn 16, Issue 2, 2015, Pages 93-98

  Wei, Jianwen ^a   Karsenty, Gerard ^a  

^a Department of Genetics & Development College of Physicians and Surgeons Columbia University ^*  (United States)

Author keywords

Energy metabolism; Osteoblast; Osteocalcin

Indexed keywords

OSTEOCALCIN; G PROTEIN COUPLED RECEPTOR; GPRC6A PROTEIN, MOUSE; INSULIN;

BONE MASS; BONE MINERALIZATION; CYTOLOGY; ENDOCRINE FUNCTION; ENERGY METABOLISM; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RELEASE; METABOLISM; NONHUMAN; OSTEOBLAST; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BONE; PHYSIOLOGY; PROTEIN PROCESSING; SECRETION (PROCESS);

ANIMALS; BONE AND BONES; ENERGY METABOLISM; HUMANS; INSULIN; OSTEOBLASTS; OSTEOCALCIN; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84925401286     PISSN: 13899155     EISSN: 15732606     Source Type: Journal    
DOI: 10.1007/s11154-014-9307-7     Document Type: Review

References (50)

1. Hall TJ, Schaeublin M, Chambers TJ. The majority of osteoclasts require mRNA and protein synthesis for bone resorption in vitro. Biochem Biophys Res Commun. 1993;195:1245–53.
2. Kim JM, Jeong D, Kang HK, Jung SY, et al. Osteoclast precursors display dynamic metabolic shifts toward accelerated glucose metabolism at an early stage of RANKL-stimulated osteoclast differentiation. Cell Physiol Biochem. 2007;20:935–46.
3. Rodan GA, Martin TJ. Therapeutic approaches to bone diseases. Science. 2000;289:1508–14.
4. Karsenty G, Kronenberg HM, Settembre C. Genetic control of bone formation. Annu Rev Cell Dev Biol. 2009;25:629–48.
5. Audi L, Vargas DM, Gussinye M, Yeste D, et al. Clinical and biochemical determinants of bone metabolism and bone mass in adolescent female patients with anorexia nervosa. Pediatr Res. 2002;51:497–504.
6. Faridi MM, Ansari Z, Bhargava SK. Imprints of protein energy malnutrition on the skeleton of children. J Trop Pediatr. 1984;30:150–3.
7. Fazeli PK, Klibanski A. Bone metabolism in anorexia nervosa. Curr Osteoporos Rep. 2014;12:82–9.
8. Himes JH. Bone growth and development in protein-calorie malnutrition. World Rev Nutr Diet. 1978;28:143–87.
9. Jacoangeli F, Zoli A, Taranto A, Staar Mezzasalma F, et al. Osteoporosis and anorexia nervosa: relative role of endocrine alterations and malnutrition. Eat Weight Disord. 2002;7:190–5.
10. Mika C, Holtkamp K, Heer M, Gunther RW, et al. A 2-year prospective study of bone metabolism and bone mineral density in adolescents with anorexia nervosa. J Neural Transm. 2007;114:1611–8.
11. Misra M, Katzman DK, Cord J, Manning SJ, et al. Bone metabolism in adolescent boys with anorexia nervosa. J Clin Endocrinol Metab. 2008;93:3029–36.
12. Misra M, Klibanski A. Bone metabolism in adolescents with anorexia nervosa. J Endocrinol Invest. 2011;34:324–32.
13. Misra M, Klibanski A. Anorexia nervosa, obesity and bone metabolism. Pediatr Endocrinol Rev. 2013;11:21–33.
14. Misra M, Miller KK, Bjornson J, Hackman A, et al. Alterations in growth hormone secretory dynamics in adolescent girls with anorexia nervosa and effects on bone metabolism. J Clin Endocrinol Metab. 2003;88:5615–23.
15. Soyka LA, Grinspoon S, Levitsky LL, Herzog DB, et al. The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab. 1999;84:4489–96.
16. Hauschka PV, Lian JB, Gallop PM. Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. Proc Natl Acad Sci U S A. 1975;72:3925–9.
17. Price PA, Otsuka AA, Poser JW, Kristaponis J, et al. Characterization of a gamma-carboxyglutamic acid-containing protein from bone. Proc Natl Acad Sci U S A. 1976;73:1447–51.
18. Price PA, Poser JW, Raman N. Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone. Proc Natl Acad Sci U S A. 1976;73:3374–5.
19. Desbois C, Hogue DA, Karsenty G. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. J Biol Chem. 1994;269:1183–90.
20. Ducy P, Desbois C, Boyce B, Pinero G, et al. Increased bone formation in osteocalcin-deficient mice. Nature. 1996;382:448–52.
21. Mauro LJ, Olmsted EA, Skrobacz BM, Mourey RJ, et al. Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation. J Biol Chem. 1994;269:30659–67.
22. Morrison DF, Mauro LJ. Structural characterization and chromosomal localization of the mouse cDNA and gene encoding the bone tyrosine phosphatase, mOST-PTP. Gene. 2000;257:195–208.
23. Lee NK, Sowa H, Hinoi E, Ferron M, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130:456–69.
24. Poser JW, Esch FS, Ling NC, Price PA. Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue. J Biol Chem. 1980;255:8685–91.
25. Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A. 2008;105:5266–70.
26. Ferron M, Wei J, Yoshizawa T, Ducy P, et al. An ELISA-based method to quantify osteocalcin carboxylation in mice. Biochem Biophys Res Commun. 2010;397:691–6.
27. Ferron M, Wei J, Yoshizawa T, Del Fattore A, et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 2010;142:296–308.
28. Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell. 2010;142:309–19.
29. Wei J, Ferron M, Clarke CJ, Hannun YA, et al. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014;124:1–13.
30. Garanty-Bogacka B, Syrenicz M, Rac M, Krupa B, et al. Association between serum osteocalcin, adiposity and metabolic risk in obese children and adolescents. Endokrynol Pol. 2013;64:346–52.
31. Hwang YC, Jeong IK, Ahn KJ, Chung HY. The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects. Diabetes Metab Res Rev. 2009;25:768–72.
32. Hwang YC, Jeong IK, Ahn KJ, Chung HY (2011) Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level. Osteoporos Int
33. Im JA, Yu BP, Jeon JY, Kim SH. Relationship between osteocalcin and glucose metabolism in postmenopausal women. Clin Chim Acta. 2008;396:66–9.
34. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, et al. Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2009;94:45–9.
35. Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, et al. Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int. 2011;22:187–94.
36. Kim GS, Jekal Y, Kim HS, Im JA, et al. Reduced serum total osteocalcin is associated with central obesity in Korean children. Obes Res Clin Pract. 2014;8:e201–298.
37. Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, et al. Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res. 2009;24:785–91.
38. Levinger I, Jerums G, Stepto NK, Parker L, et al. The effect of acute exercise on undercarboxylated osteocalcin and insulin sensitivity in obese men. J Bone Miner Res. 2014.
39. Strapazzon G, De Toni L, Foresta C. Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int. 2011;22:1643–4.
40. Wedrychowicz A, Stec M, Sztefko K, Starzyk JB. Associations between Bone, Fat Tissue and Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus. Exp Clin Endocrinol Diabetes. 2014;122:491–5.
41. Zhou M, Ma X, Li H, Pan X, et al. Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals. Eur J Endocrinol. 2009;161:723–9.
42. Oury F, Sumara G, Sumara O, Ferron M, et al. Endocrine regulation of male fertility by the skeleton. Cell. 2011;144:796–809.
43. Wellendorph P, Brauner-Osborne H. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene. 2004;335:37–46.
44. Pi M, Faber P, Ekema G, Jackson PD, et al. Identification of a novel extracellular cation-sensing G-protein-coupled receptor. J Biol Chem. 2005;280:40201–9.
45. Wei J, Hanna T, Suda N, Karsenty G, et al. Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a. Diabetes. 2014;63:1021–31.
46. Boisen KA, Main KM, Rajpert-De Meyts E, Skakkebaek NE. Are male reproductive disorders a common entity? The testicular dysgenesis syndrome. Ann N Y Acad Sci. 2001;948:90–9.
47. Glass AR, Vigersky RA. Testicular reserve of testosterone precursors in primary testicular failure. Fertil Steril. 1982;38:92–6.
48. Paduch DA. Testicular cancer and male infertility. Curr Opin Urol. 2006;16:419–27.
49. Winters SJ, Troen P. A reexamination of pulsatile luteinizing hormone secretion in primary testicular failure. J Clin Endocrinol Metab. 1983;57:432–5.
50. Oury F, Ferron M, Huizhen W, Confavreux C, et al. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest. 2013;123:2421–33.