Reduced serum total osteocalcin is associated with central obesity in Korean children

Obesity Research and Clinical Practice

Volumn 8, Issue 3, 2014, Pages

  Kim, Gwang Suk ^a   Jekal, Yoonsuk ^b   Kim, Hee Soon ^a   Im, Jee Aee ^c   Park, Ji Young ^a   Chu, Sang Hui ^a  

^a Yonsei University   (South Korea)

^b Jeju National University   (South Korea)

^c INTOTO Inc   (South Korea)

Author keywords

Children; Obesity; Osteocalcin

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; OSTEOCALCIN; TRIACYLGLYCEROL; GLUCOSE BLOOD LEVEL; LIPID;

ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY FAT; BODY MASS; CHILD; CHILDHOOD DISEASE; CHILDHOOD OBESITY; CROSS-SECTIONAL STUDY; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KOREAN (PEOPLE); MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PHENOTYPE; PRIORITY JOURNAL; SCHOOL CHILD; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO; BLOOD; DEFICIENCY; METABOLISM; OBESITY, ABDOMINAL; PREDICTIVE VALUE; RISK FACTOR; SOUTH KOREA;

BLOOD GLUCOSE; BODY MASS INDEX; C-REACTIVE PROTEIN; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INSULIN RESISTANCE; LIPIDS; MALE; METABOLIC SYNDROME X; OBESITY, ABDOMINAL; OSTEOCALCIN; PHENOTYPE; PREDICTIVE VALUE OF TESTS; REPUBLIC OF KOREA; RISK FACTORS; WAIST CIRCUMFERENCE;

EID: 84900515052     PISSN: 1871403X     EISSN: 18780318     Source Type: Journal    
DOI: 10.1016/j.orcp.2012.12.003     Document Type: Article

References (24)

1. The fourth Korean national health and mutrition examination (KNHAMES IV) 2009 Ministry of Health and Welfare Seoul
2. S. Karnik, and A. Kanekar Childhood obesity: a global public health crisis Int J Prev Med 3 2012 1 7
3. A.A. Bremer, M. Mietus-Snyder, and R.H. Lustig Toward a unifying hypothesis of metabolic syndrome Pediatrics 129 2012 557 570 10.1542/peds.2011-2912 peds.2011-2912 [pii]
4. A.G. Pittas, S.S. Harris, M. Eliades, P. Stark, and B. Dawson-Hughes Association between serum osteocalcin and markers of metabolic phenotype J Clin Endocrinol Metab 94 2009 827 832 10.1210/jc.2008-1422 jc.2008-1422 [pii]
5. B.B. Yeap, S.A. Chubb, L. Flicker, K.A. McCaul, P.R. Ebeling, and J.P. Beilby et al. Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels Eur J Endocrinol 163 2010 265 272 10.1530/EJE-10-0414 EJE-10-0414 [pii]
6. S.J. Bae, J.W. Choe, Y.E. Chung, B.J. Kim, S.H. Lee, and H.Y. Kim et al. The association between serum osteocalcin levels and metabolic syndrome in Koreans Osteoporos Int 22 2011 2837 2846 10.1007/s00198-010-1504-y
7. Y. Bao, M. Zhou, Z. Lu, H. Li, Y. Wang, and L. Sun et al. Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men Clin Endocrinol (Oxf) 75 2011 196 201 10.1111/j.1365-2265.2011.04065.x
8. T. Reinehr, and C.L. Roth A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss Int J Obes (Lond) 34 2010 852 858 10.1038/ijo.2009.282 ijo.2009.282 [pii]
9. N.K. Pollock, P.J. Bernard, B.A. Gower, C.M. Gundberg, K. Wenger, and S. Misra et al. Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with beta-cell function J Clin Endocrinol Metab 96 2011 E1092 E1099 10.1210/jc.2010-2731 jc.2010-2731 [pii]
10. D.H. Lee The criteria and treatment guideline for pediatric obesity J Korean Soc Stud Obes Training Mater 4 2002 57 96
11. T. Ohzeki, Y. Nakagawa, and F. Ochiai Epidemiology and diagnostic criteria for metabolic syndrome and obesity in Japanese children Nihon Rinsho 69 Suppl. 1 2011 745 751
12. N.E. Jensky-Squires, C.M. Dieli-Conwright, A. Rossuello, D.N. Erceg, S. McCauley, and E.T. Schroeder Validity and reliability of body composition analysers in children and adults Br J Nutr 100 2008 859 865 10.1017/ S0007114508925460 S0007114508925460 [pii]
13. J.A. Im, B.P. Yu, J.Y. Jeon, and S.H. Kim Relationship between osteocalcin and glucose metabolism in postmenopausal women Clin Chim Acta 396 2008 66 69 10.1016/j.cca.2008.07.001 S0009-8981(08)00329-X [pii]
14. S.H. Kim, J.W. Lee, J.A. Im, and H.J. Hwang Serum osteocalcin is related to abdominal obesity in Korean obese and overweight men Clin Chim Acta 411 2010 2054 2057 10.1016/j.cca.2010.08.046 S0009-8981(10)00567-X [pii]
15. A. Garcia-Martin, M. Cortes-Berdonces, I. Luque-Fernandez, P. Rozas-Moreno, M. Quesada-Charneco, and M. Munoz-Torres Osteocalcin as a marker of metabolic risk in healthy postmenopausal women Menopause 18 2011 537 541 10.1097/gme.0b013e3181f 8565e
16. N. Gungor, R. Saad, J. Janosky, and S. Arslanian Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents J Pediatr 144 2004 47 55 10.1016/j.jpeds.2003.09.045 S0022-3476(03)00673-5 [pii]
17. L.S. Conwell, S.G. Trost, W.J. Brown, and J.A. Batch Indexes of insulin resistance and secretion in obese children and adolescents: a validation study Diabetes Care 27 2004 314 319
18. M. Ferron, E. Hinoi, G. Karsenty, and P. Ducy Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice Proc Natl Acad Sci USA 105 2008 5266 5270 10.1073/pnas.0711119105 0711119105 [pii]
19. I. Kanazawa, T. Yamaguchi, M. Yamauchi, M. Yamamoto, S. Kurioka, and S. Yano et al. Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus Osteoporos Int 22 2011 187 194 10.1007/s00198-010-1184-7
20. N.K. Lee, H. Sowa, E. Hinoi, M. Ferron, J.D. Ahn, and C. Confavreux et al. Endocrine regulation of energy metabolism by the skeleton Cell 130 2007 456 469 10.1016/j.cell.2007.05.047 S0092-8674(07)00701-5 [pii]
21. M.K. Shea, C.M. Gundberg, J.B. Meigs, G.E. Dallal, E. Saltzman, and M. Yoshida et al. Gamma-carboxylation of osteocalcin and insulin resistance in older men and women Am J Clin Nutr 90 2009 1230 1235 10.3945/ajcn.2009.28151 ajcn.2009.28151 [pii]
22. L.E. Polgreen, D.R. Jacobs, B.M. Nathan, J. Steinberger, A. Moran, and A.R. Sinaiko Association of osteocalcin with obesity, insulin resistance, and cardiovascular risk factors in young adults Obesity (Silver Spring) 2012 10.1038/oby.2012.108 oby.2012.108 [pii]
23. Y.C. Hwang, I.K. Jeong, K.J. Ahn, and H.Y. Chung The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects Diabetes Metab Res Rev 25 2009 768 772 10.1002/dmrr.1045
24. A. Prats-Puig, M. Mas-Parareda, E. Riera-Perez, D. Gonzalez-Forcadell, C. Mier, and M. Mallol-Guisset et al. Carboxylation of osteocalcin affects its association with metabolic parameters in healthy children Diabetes Care 33 2010 661 663 10.2337/dc09-1837 dc09-1837 [pii]