Association between serum osteocalcin, adiposity and metabolic risk in obese children and adolescents

Endokrynologia Polska

Volumn 64, Issue 5, 2013, Pages 346-352

  Garanty Bogacka, Barbara ^a   Syrenicz, Małgorzata ^a   Rać, Monika ^a   Krupa, Beata ^a   Czaja Bulsa, Grazyna ^a   Walczak, Mieczysław ^a   Sowińska Przepiera, Elzbieta ^a   Syrenicz, Anhelli ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

Adolescents; Children; Metabolic disorders; Obesity; Osteocalcin

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; FIBRINOGEN; GLUCOSE; HEMOGLOBIN; HEMOGLOBIN A1C; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OSTEOCALCIN; TRIACYLGLYCEROL; 25-HYDROXYVITAMIN D; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; VITAMIN D;

ABDOMINAL OBESITY; ADOLESCENCE; ADOLESCENT; ADULT; AGE; ARTICLE; BLOOD PRESSURE; BODY FAT; BODY MASS; CHILD; CHILDHOOD OBESITY; DISEASE ASSOCIATION; FEMALE; FIBRINOGEN BLOOD LEVEL; GENDER; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; METABOLISM; PRESCHOOL CHILD; PROTEIN BLOOD LEVEL; PUBERTY; RISK ASSESSMENT; SCHOOL CHILD; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL; WAIST CIRCUMFERENCE; ADIPOSE TISSUE; ANALOGS AND DERIVATIVES; ANALYSIS; BLOOD; OBESITY; PHYSIOLOGY; REGRESSION ANALYSIS; RISK FACTOR;

ADIPOSE TISSUE; ADIPOSITY; ADOLESCENT; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY MASS INDEX; C-REACTIVE PROTEIN; CHILD; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; INSULIN RESISTANCE; LEUKOCYTE COUNT; MALE; OBESITY; OSTEOCALCIN; REGRESSION ANALYSIS; RISK FACTORS; TRIGLYCERIDES; VITAMIN D; WAIST CIRCUMFERENCE;

EID: 84888869750     PISSN: 0423104X     EISSN: None     Source Type: Journal    
DOI: 10.5603/EP.2013.0016     Document Type: Article

References (34)

1. Weiss R, Dziura J, Burgert TS et al. Obesity and the metabolic syndrome in children and adolescents. N Eng J Med 2004; 350: 2362-2374.
2. Goulding A, Jones IE, Taylor RW et al. Bone mineral density and body composition in boys with distal forearm fractures: a dual-energy x-ray absorptiometry study. J Pediatr 2001; 139: 509-515.
3. Shanahan CM, Cary NR, Metcalfe JC et al. High expression of genes for calcification-regulating protein in human atherosclerotic plaques. J Clin Invest 1994; 93: 2393-2402.
4. Lee NK, Sowa H, Hinoi E et al. Endocrine regulation of energy metabolism by the skeleton. Cell 2007; 130: 456-469.
5. Ferron M, Hinoi E, Karsenty G et al. Osteocalcin differentially regulates β cell and adopocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 2008; 105: 5266-5270.
6. Ferron M, McKee MD, Levine RL et al. Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone 2012; 50: 568-575.
7. Palczewska I, Niedźwiecka Z. Somatic development indices in children and youth of Warsaw. Dev Period Med 2001; 2 (Suppl.): 113-114.
8. Nawarycz T, Ostrowska-Nawarycz L. Percentile distributions of waist circumference in children and adolescents. Pediatr Pol 2007; 82: 418-424.
9. Mathews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
10. Rached MT, Kode A, Silva BC et al. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest 2010; 120: 357-368.
11. Kim SH, Lee JW, Im JA et al. Serum osteocalcin is related to abdominal obesity in Korean obese and overweight men. Clin Chim Acta 2010; 411: 2054-2057.
12. Fernandez-Real JM, Izquierdo M, Ortega F et al. The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab 2009; 94: 237-245.
13. Kindblom JM, Ohlsson C, Ljunggren O et al. Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 2009; 24: 785-791.
14. Iglesias P, Arrieta F, Pinera M et al. Serum concentrations of osteocalcin, protocollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance. Clin Endocrinol 2011; 75: 184-188.
15. Zhou M, Ma X, Li H et al. Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals. Eur J Endocrinol 2009; 161: 723-729.
16. Kanazawa I, Yamaguchi T, Yamamoto M et al. Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endorinol Metab 2009; 94: 45-49.
17. Levinger I, Zebaze R, Jerums G et al. The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporos Int 2011; 22: 1621-1626.
18. Pittas AG, Harris SS, Eliades M et al. Assoiation between serum osteocalcin and markers of metabolic syndrome. J Clin Endocrinol Metab 2009; 94; 827-832.
19. Saleem U, Mosley TH, Kullo IJ. Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol 2010; 30: 1474-1478.
20. Yeap BB, Chubb SA, Flicker L et al. Association of total osteocalcin with all-cause and cardiovascular mortality in older men: the Health in men study. Osteoporos Int 2012; 23: 599-606.
21. Prats-Puig A, Mas-Parareda M, Riera-Perez E et al. Carboxylation of osteocalcin affects its association with metabolic parameters in healthy children. Diabetes Care 2010; 33: 661-663.
22. Reinher T, Roth CL. A new link between skeleton, obesity and insulin resistance: relationship between osteocalcin, leptin and insulin resistance in obese children before and after weight loss. Int J Obes 2010; 34: 852-858.
23. Rochefort GY, Rocher E, Aveline PC et al. Osteocalcin-insulin relationship in obese children: a role for the skeleton in energy metabolism. Clin Endocrinol 2011; 75: 265-270.
24. Pollock NK, Bernard PJ, Wenger K et al. Lower bone mass in prepubertal children with prediabetes. J Bone Miner Res 2010; 25: 2760-2769.
25. Boucher-Berry C, Speiser PW, Carey DE et al. Vitamin D, osteocalcin, and risk for adiposity as comorbidities in middle school children. J Bone Miner Res 2012; 27: 283-293.
26. Jebb SA, Cole TJ, Doman D et al. Evaluation of the novel Tanita body-fat analyser to measure body composition by comparison with a fourcompartment model. Br J Nutr 2000; 83: 115-122.
27. Magnusson P, Hager A, Larsson L. Serum osteocalcin and bone and liver alkaline phosphatase isoforms in healthy children and adolescents. Pediatr Res 1995; 38: 955-961.
28. Fares JE, Choucair M, Nabulsi M et al. Effect of gender, puberty, and vitamin D status on biochemical markers of bone remodelling. Bone 2003; 33: 242-247.
29. Orwoll ES, Beknap JK, Klein RF. Gender specificity in the genetic determinants of peak bone mass. J Bone Min Res 2001; 16: 1962-1971.
30. Cadogan J, Blumsohn A, Barker M et al. Longitudinal study of bone gain in pubertal girls: anthropometric and biochemical correlates. J Bone Min Res 1998; 13: 1602-1612.
31. Shea MK, Gundberg CM, Meigs JB et al. γ-Carboxylation of osteocalcin and insulin resistance in older men and women. Am J Clin Nutr 2009; 90: 1230-1235.
32. Schafer AL, Sellmeyer DE, Schwartz AV et al. Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1-84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH Study). J Clin Endocrinol Metab 2011; 96: E1982-E1989.
33. Fernandez-Real JM, Ricart W. Osteocalcin: a new link between bone and energy metabolism. Some evolutionary clues. Curr Opin Clin Nutr Metab Care 2011; 14: 360-366.
34. Foresta C, Strapazon G, De Toni L et al. Evidence for osteocalcin production by adipose tissue and its role in human metabolism. J Clin Endocrinol Metab 2010; 95: 3502-3506.