Alterations in Growth Hormone Secretory Dynamics in Adolescent Girls with Anorexia Nervosa and Effects on Bone Metabolism

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 12, 2003, Pages 5615-5623

  Misra, Madhusmita ^a,b   Miller, Karen K ^a   Bjornson, Jennifer ^a   Hackman, Annie ^a   Aggarwal, Avichal ^a   Chung, Joyce ^a   Ott, Melissa ^c   Herzog, David B ^a   Johnson, Michael L ^d   Klibanski, Anne ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Eating Disorders Center   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GROWTH HORMONE; HYDROCORTISONE; LEPTIN; SOMATOMEDIN C;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; AREA UNDER THE CURVE; ARTICLE; BODY MASS; BONE AGE; BONE DENSITY; BONE METABOLISM; BONE TURNOVER; CLINICAL ARTICLE; ENTROPY; FEMALE; GROWTH HORMONE RELEASE; HORMONE RESISTANCE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NUTRITIONAL STATUS; ONSET AGE; OSSIFICATION; OSTEOPENIA; PREVALENCE; PRIORITY JOURNAL; PULSATILE FLOW;

ADOLESCENT; ANOREXIA NERVOSA; ANTHROPOMETRY; BIOLOGICAL MARKERS; BONE DENSITY; BONE REMODELING; FEMALE; HORMONES; HUMAN GROWTH HORMONE; HUMANS; NUTRITIONAL STATUS;

EID: 9144224949     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030532     Document Type: Article

References (55)

1. Lucas AR, Beard CM, O'Fallon WM, Kurland LT 1991 50-year trends in the incidence of anorexia nervosa in Rochester, MN: a population-based study. Am J Psychiatry 148:917-922
2. Von Ranson K, Iacono W, McGue M 2002 Disordered eating and substance abuse in an epidemiological sample. I. Associations within individuals. Int J Eat Disord 31:389-403
3. Bachrach L, Guido D, Katzman D, Litt I, Marcus R 1990 Decreased bone density in adolescent girls with anorexia nervosa. Pediatrics 86:440-447
4. Biller B, Saxe V, Herzog D, Rosenthal D, Holzman S, Klibanski A 1989 Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab 68:548-554
5. Rigotti N, Neer R, Skates S, Herzog D, Nussbaum S 1991 The clinical course of osteoporosis in anorexia nervosa. JAMA 265:1133-1138
6. Grinspoon S, Baum H, Lee K, Anderson E, Herzog D, Klibanski A 1996 Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab 81:3864-3870
7. Jagielska G, Wolanczyk T, Komender J, Tomaszewicz-Libudzic C, Przedlacki J, Ostrowski K 2001 Bone mineral content and bone mineral density in adolescent girls with anorexia nervosa: a longitudinal study. Acta Psychiatr Scand 104:131-137
8. Soyka L, Grinspoon S, Levitsky L, Herzog D, Klibanski A 1999 The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab 84:4489-4496
9. Kooh S, Noriega E, Leslie K, Muller C, Harrison J 1996 Bone mass and soft tissue composition in adolescents with anorexia nervosa. Bone 19:181-188
10. Bachrach L, Katzman D, Litt I, Guido D, Marcus R 1991 Recovery from osteopenia in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 72:602-606
11. Soyka L, Misra M, Frenchman A, Miller K, Grinspoon S, Schoenfeld D, Klibanski A 2002 Abnormal bone mineral accrual in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 87:4177-4185
12. Levine R 2002 Endocrine aspects of eating disorders in adolescents. Adolesc Med 13:129-143
13. Douyon L, Schteingart D 2002 Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion. Endocrinol Metab Clin North Am 31:173-189
14. Tamai H, Mon K, Matsubayashi S, Kiyohara K, Nakagawa T, Okimura M, Walter RJ, Kumagai L, Nagataki S 1986 Hypothalamic-pituitary-thyroidal dysfunctions in anorexia nervosa. Psychother Psychosom 46:127-131
15. Stoving R, Veldhuis J, Flyvbjerg A, Vinten J, Hangaard J, Koldkjaer O, Kristiansen J, Hagen C 1999 Jointly amplified basal and pulsatile growth hormone secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the growth hormone-insulin like growth factor-I axis. J Clin Endocrinol Metab 84:2056-2063
16. Salisbury JJ, Mitchell JE 1991 Bone mineral density and anorexia nervosa in women. Am J Psychiatry 148:768-774
17. Boyar R, Hellman L, Roffwarg H, Katz J, Zumoff B, O'Connor J, Bradlow H, Fukushima D 1977 Cortisol secretion and metabolism in anorexia nervosa. N Engl J Med 296:190-193
18. Golden N, Kreitzer P, Jacobson M, Chasalow F, Schebendach J, Freedman S, Shenker I 1994 Disturbances in growth hormone secretion and action in adolescents with anorexia nervosa. J Pediatr 125:655-660
19. Argente J, Caballo N, Barrios V, Munoz M, Pozo J, Chowen J, Morande G, Hernandez M 1997 Multiple endocrine abnormalities of the growth hormone and insulin like growth factor-I axis in patients with anorexia nervosa: effect of long- and short-term weight recuperation. J Clin Endocrinol Metab 82: 2084-2092
20. Counts D, Gwirtsman H, Carlsson L, Lesem M, Cutler G 1992 The effect of anorexia nervosa and refeeding on growth hormone-binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab 75:762-767
21. Scacchi M, Pincelli A, Caumo A, Tomasi P, Delitala G, Baldi G, Cavagnini F 1997 Spontaneous nocturnal growth hormone secretion in anorexia nervosa. J Clin Endocrinol Metab 82:3225-3229
22. Grinspoon S, Miller K, Coyle C, Krempin J, Armstrong C, Pitts S, Herzog D, Klibanski A 1999 Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea. J Clin Endocrinol Metab 84:2049-2055
23. Turner J, Bulsara M, McDermott B, Byrne G, Prince R, Forbes D 2001 Predictors of low bone density in young adolescent females with anorexia nervosa and other dieting disorders. Int J Eat Disord 30:245-251
24. Baker D, Roberts R, Towell T 2000 Factors predictive of bone mineral density in eating disordered women: a longitudinal study. Int J Eat Disord 27:29-35
25. Castro J, Iazaro L, Pons F, Halperin I, Toro J 2000 Predictors of bone mineral density reduction in adolescents with anorexia nervosa. J Am Acad Child Adol Psychol 39:1365-1370
26. Audi L, Vargas D, Gussinye M, Yeste D, Marti G, Carrascosa A 2002 Clinical and biochemical determinants of bone metabolism and bone mass in adolescent female patients with anorexia nervosa. Pediatr Res 51:497-504
27. Ohlsson C, Bengtsson B, Isaksson O, Andreassen T, Slootweg M 1998 Growth hormone and bone. Endocr Rev 19:55-79
28. Hock J, Centrella M, Canalis E 1988 Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology 122:254-260
29. Ogden C, Kuczmarski R, Flegal K, Mei Z, Guo S, Wei R, Grummer-Strawn L, Curtin L, Roche A, Johnson C 2002 Centers for Diseases Control and Prevention 2000 growth charts for the United States: improvements to the 1997 National Center for health Statistics version. Pediatrics 109:45-60
30. Greulich W, Pyle S 1959 Radiographic atlas of skeletal development of the hand and wrist, 2nd Ed. Stanford, CA: Stanford University Press
31. Massachusetts General Hospital 1992 Case records of the Massachusetts General Hospital Weekly clinicopathological exercises. Normal reference laboratory values. N Engl J Med. 327:718-724
32. Legro R, Lin H, Demers L, Lloyd T 2003 Urinary free cortisol increases in adolescent Caucasian females during perimenarche. J Clin Endocrinol Metab 88:215-219
33. Veldhuis J, Johnson M 1986 Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol 250:E486-E493
34. Veldhuis J, Carlson M, Johnson M 1987 The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84:7686-7690
35. Veldhuis J, Johnson M 1992 Deconvolution analysis of hormone data. Methods Enzymol 210:539-575
36. Katzman D, Bachrach L, Carter D, Marcus R 1991 Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metab 73:1332-1339
37. Kelly T, Berger N, Richardson T 1998 DXA body composition: theory and practice. Appl Radiat Isot 49:511-513
38. Visser M, Fuerst T, Lang T, Salamone L, Harris T 1999 Validity of fan-beam dual energy x-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, aging, and body composition study: Dual Energy X-ray Absorptiometry and Body Composition Working Group. J Appl Physiol 87: 1513-1520
39. Masuda A, Shibasaki T, Hotta M, Suematsu H, Shizume K 1988 Study on the mechanism of abnormal growth hormone (GH) secretion in anorexia nervosa: no evidence of involvement of low somatomedin-C level in the abnormal GH secretion. J Endocrinol Invest 11:297-302
40. Cara J, Rosenfield R, Furlanetto R 1987 A longitudinal study of the relationship of plasma somatomedin-C concentration to the pubertal growth spurt. Am J Dis Child 141:562-564
41. Cara J 1993 Growth hormone in adolescence. Normal and abnormal. Endocrinol Metab Clin North Am 22:533-552
42. van Dam EWCM, Roelfsema F, Helmerhorst FH, Frolich M, Meinders AE, Veldhuis JD, Fiji H 2002 Low amplitude and disorderly spontaneous growth hormone release in obese women with or without polycystic ovary syndrome. J Clin Endocrinol Metab 87:4225-4230
43. Veldhuis JD, Roemmich JN, Rogol AD 2000 Gender and sexual maturation-dependent contrasts in the neuroregulation of growth hormone secretion in prepubertal and late adolescent males and females: a general clinical research center-based study. J Clin Endocrinol Metab 85:2385-2394
44. Giustina A, Veldhuis J 1998 Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19:717-797
45. Andersen M, Stoving R, Hangaard J, Petersen P, Hagen C 1998 The effect of short-term cortisol changes on growth hormone responses to the pyridostigmine-growth-hormone-releasing-hormone test in healthy adults and patients with suspected growth hormone deficiency. Clin Endocrinol (Oxf) 49:241-249
46. Bergendahl M, Vance M, Iranmanesh A, Thorner M, Veldhuis J 1996 Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men. J Clin Endocrinol Metab 81:692-699
47. Schaefer F, Veldhuis J, Stanhope R, Jones J, Scharer K 1994 Alterations in growth hormone secretion and clearance in peripubertal boys with chronic renal failure and after renal transplantation. Cooperative Study Group of Pubertal development in Chronic Renal Failure. J Clin Endocrinol Metab 78:1298-1306
48. Janssen Y, Frolich M, Deurenberg P, Roelfsema F 1997 Serum leptin levels during recombinant human GH therapy in adults with GH deficiency. Eur J Endocrinol 137:650-654
49. Bachrach L, Marcus R, Ott S, Rosenbloom A, Vasconez O, Martinez V, Martinez A, Rosenfeld R, Guevara-Aguirre J 1998 Bone mineral, histomorphometry, and body composition in adults with growth hormone receptor deficiency. J Bone Miner Res 13:415-421
50. Bagnasco M, Kalra P, Kalra S 2002 Ghrelin and leptin pulse discharge in fed and fasted rats. Endocrinology 143:726-729
51. Tolle V, Kadem M, Bluet-Pajot M-T, Frere D, Foulon C, Bossu C, Dardennes R, Mounier C, Zizzari P, Lang F, Epelbaum J, Estour B 2003 Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. J Clin Endocrinol Metab 88:109-116
52. Laughlin G, Dominguez C, Yen S 1998 Nutritional and endocrine-metabolic aberrations in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab 83:25-32
53. Veldhuis J, Liem A, South S, Weltman A, Weltman J, Clemmons D, Abbott R, Mulligan T, Johnson M, Pincus S, Straume M, Iramanesh A 1995 Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J Clin Endocrinol Metab 80:3209-3222
54. Grinspoon S, Baum H, Kim V, Coggins C, Klibanski A 1995 Decreased bone formation and increased mineral dissolution during acute fasting in young women. J Clin Endocrinol Metab 80:3628-3633
55. Laron Z, Klinger B 1994 IGF-I treatment of adult patients with Laron syndrome: preliminary results. Clin Endocrinol (Oxf) 41:631-638