Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation

Journal of Clinical Investigation

Volumn 124, Issue 4, 2014, Pages 1-13

  Wei, Jianwen ^a   Ferron, Mathieu ^a,b   Clarke, Christopher J ^c   Hannun, Yusuf A ^c   Jiang, Hongfeng ^a   Blaner, William S ^a   Karsenty, Gerard ^a  

^a Department of Genetics and Development College of Physicians and Surgeons Columbia University ^*  (United States)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c Stony Brook Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; FREE SATURATED FATTY ACID; GLUCOSE; INSULIN; INSULIN RECEPTOR; OSTEOCALCIN; SATURATED FATTY ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; GENE OVEREXPRESSION; GENE REPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NONHUMAN; OSTEOBLAST; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; UBIQUITINATION; WHOLE BODY GLUCOSE HOMEOSTASIS;

ANIMALS; ANTIGENS, CD; BONE AND BONES; BONE RESORPTION; DIET, HIGH-FAT; FATTY ACIDS, NONESTERIFIED; GLUCOSE; GLUCOSE INTOLERANCE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; OSTEOBLASTS; OSTEOCALCIN; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 84897558108     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI72323     Document Type: Article

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