Single amino acid change in STING leads to constitutive active signaling

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Tang, Eric D ^a   Wang, Cun Yu ^a  

^a UCLA SCHOOL OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; BETA INTERFERON; LYSINE; MEMBRANE PROTEIN; METHIONINE; PROTEIN SERINE THREONINE KINASE; PROTEIN STING; PROTEIN TBK1; THREONINE; UNCLASSIFIED DRUG; CYCLIC GMP; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; IRF3 PROTEIN, HUMAN; MB21D1 PROTEIN, HUMAN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE; TBK1 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIMERIZATION; DOWN REGULATION; GENE MUTATION; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; CHEMISTRY; CYTOSOL; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MISSENSE MUTATION; PROTEIN MULTIMERIZATION;

AMINO ACID SUBSTITUTION; CYCLIC GMP; CYTOSOL; DNA; HEK293 CELLS; HUMANS; INTERFERON REGULATORY FACTOR-3; MEMBRANE PROTEINS; MUTATION, MISSENSE; NF-KAPPA B; NUCLEOTIDYLTRANSFERASES; PROTEIN MULTIMERIZATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84925400752     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120090     Document Type: Article

References (28)

1. Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011; 478: 515-518. doi: 10.1038/nature10429 PMID: 21947006
2. Ishikawa H, Barber GN STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature. 2008; 455: 674-678. doi: 10.1038/nature07317 PMID: 18724357
3. Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, et al. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011; 187: 2595-2601. doi: 10.4049/jimmunol.1100088 PMID: 21813776
4. Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol. 2008; 28: 5014-5026. doi: 10.1128/MCB.00640-08 PMID: 18559423
5. Sun W, Li Y, Chen L, Chen H, You F, Zhou X, et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A. 2009; 106: 8653-8658. doi: 10.1073/pnas.0900850106 PMID: 19433799
6. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity. 2008; 29: 538-550. doi: 10.1016/j.immuni.2008.09.003 PMID: 18818105
7. Cai X, Chiu YH, Chen ZJ The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol Cell. 2014; 54: 289-296. doi: 10.1016/j.molcel.2014.03.040 PMID: 24766893
8. Sun L, Wu J, Du F, Chen X, Chen ZJ Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013; 339: 786-791. doi: 10.1126/science.1232458 PMID: 23258413
9. Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature. 2013; 498: 332-337. doi: 10.1038/nature12305 PMID: 23722159
10. Gao P, Ascano M, Wu Y, Barchet W, Gaffney BL, Zillinger T, et al. Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 2013; 153: 1094-1107. doi: 10.1016/j.cell.2013.04.046 PMID: 23647843
11. Kranzusch PJ, Lee AS, Berger JM, Doudna JA Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep. 2013; 3: 1362-1368. doi: 10.1016/j.celrep.2013.05.008 PMID: 23707061
12. Li X, Shu C, Yi G, Chaton CT, Shelton CL, Diao J, et al. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity. 2013; 39: 1019-1031. doi: 10.1016/j.immuni.2013.10.019 PMID: 24332030
13. Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, et al. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 2014; 6: 421-430. doi: 10.1016/j.celrep.2014.01.003 PMID: 24462292
14. Ouyang S, Song X, Wang Y, Ru H, Shaw N, Jiang Y, et al. Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity. 2012; 36: 1073-1086. doi: 10.1016/j.immuni.2012.03.019 PMID: 22579474
15. Huang YH, Liu XY, Du XX, Jiang ZF, Su XD The structural basis for the sensing and binding of cyclic di-GMP by STING. Nat Struct Mol Biol. 2012; 19: 728-730. doi: 10.1038/nsmb.2333 PMID: 22728659
16. Ahn J, Gutman D, Saijo S, Barber GN STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci U S A. 2012; 109: 19386-19391. doi: 10.1073/pnas.1215006109 PMID: 23132945
17. Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr., Barber GN, et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity. 2012; 36: 120-131. doi: 10.1016/j.immuni.2011.11.018 PMID: 22284419
18. Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez M, et al. Activated STING in a Vascular and Pulmonary Syndrome. N Engl J Med. 2014; 371: 507-518. doi: 10.1056/NEJMoa1312625 PMID: 25029335
19. Li XD, Wu J, Gao D, Wang H, Sun L, Chen ZJ Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science. 2013; 341: 1390-1394. doi: 10.1126/science.1244040 PMID: 23989956
20. Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature. 2014; 505: 691-695. doi: 10.1038/nature12862 PMID: 24284630
21. Gao D, Wu J, Wu YT, Du F, Aroh C, Yan N, et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science. 2013; 341: 903-906. doi: 10.1126/science.1240933 PMID: 23929945
22. Tang ED, Wang CY MAVS self-association mediates antiviral innate immune signaling. J Virol. 2009; 83: 3420-3428. doi: 10.1128/JVI.02623-08 PMID: 19193783
23. Jin L, Xu LG, Yang IV, Davidson EJ, Schwartz DA, Wurfel MM, et al. Identification and characterization of a loss-of-function human MPYS variant. Genes Immun. 2011; 12: 263-269. doi: 10.1038/gene.2010.75 PMID: 21248775
24. Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol. 2003; 4: 491-496. PMID: 12692549
25. Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, et al. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 2013; 3: 1355-1361. doi: 10.1016/j.celrep.2013.05.009 PMID: 23707065
26. Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013; 51: 226-235. doi: 10.1016/j.molcel.2013.05.022 PMID: 23747010
27. Tanaka Y, Chen ZJ STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci Signal. 2012; 5: ra20. doi: 10.1126/scisignal.2002521 PMID: 22394562
28. Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, et al. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity. 2014; 40: 329-341. doi: 10.1016/j.immuni.2014.01.010 PMID: 24560620