PH-responsive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(d,l-lactide) for tumor-targeting and controlled delivery of doxorubicin and P-glycoprotein inhibitor

Acta Biomaterialia

Volumn 17, Issue , 2015, Pages 182-192

  Zhao, Yong ^a   Zhou, Yanxia ^a   Wang, Dishi ^a   Gao, Yajie ^a   Li, Jinwen ^a   Ma, Shujin ^a   Zhao, Lei ^a   Zhang, Chao ^a   Liu, Yan ^a   Li, Xinru ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Folate targeted delivery; Multidrug resistance; P glycoprotein inhibitor; pH responsive polymeric micelle; Poly(2 ethyl 2 oxazoline) poly(d,l lactide)

Indexed keywords

ANIONIC POLYMERIZATION; CATIONIC POLYMERIZATION; CONTROLLED DRUG DELIVERY; CRITICAL MICELLE CONCENTRATION; DISEASES; FLUORESCENCE IMAGING; GLYCOPROTEINS; INFRARED DEVICES; RING OPENING POLYMERIZATION; TARGETED DRUG DELIVERY; TUMORS;

FOLATE-TARGETED DELIVERY; FOLATES; L-LACTIDE; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; P-GLYCOPROTEIN INHIBITOR; PH-RESPONSIVE; PH-RESPONSIVE POLYMERIC MICELLE; POLY(2-ETHYL-2-OXAZOLINE); POLY(2-ETHYL-2-OXAZOLINE)-POLY(D,L-LACTIDE); POLYMERIC MICELLE; TARGETED DELIVERY;

MICELLES;

COPOLYMER; DOXORUBICIN; GLYCOPROTEIN P INHIBITOR; POLY(2 ETHYL 2 OXAZOLINE) POLY(DEXTRO LEVO LACTIDE) COPOLYMER; TPGS 1000; UNCLASSIFIED DRUG; 2-ETHYL-2-OXAZOLINE; ALPHA TOCOPHEROL; ALPHA-TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; ANTINEOPLASTIC AGENT; BIOMATERIAL; CATION; DILACTIDE; DIOXANE DERIVATIVE; LACTIC ACID; MACROGOL DERIVATIVE; MICELLE; MULTIDRUG RESISTANCE PROTEIN; OXAZOLE DERIVATIVE; POLYLACTIC ACID; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; FLOW CYTOMETRY; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MICELLE; MOUSE; NONHUMAN; PH; POLYMERIZATION; PRIORITY JOURNAL; RING OPENING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMISTRY; DRUG RESISTANCE; FLUORESCENCE MICROSCOPY; GENETICS; MULTIDRUG RESISTANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUDE MOUSE;

MUS MUSCULUS;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; CATIONS; DIOXANES; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; MICROSCOPY, FLUORESCENCE; OXAZOLES; P-GLYCOPROTEIN; POLYETHYLENE GLYCOLS; POLYMERS; VITAMIN E;

EID: 84925326349     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.01.010     Document Type: Article

References (36)

1. N.Y. Lukyanova, N.V. Rusetskya, N.A. Tregubova, and V.F. Chekhun Molecular profile and cell cycle in MCF-7 cells resistant to cisplatin and doxorubicin Exp Oncol 31 2009 87 91
2. M. Dean, and R. Allikmets Complete characterization of the human ABC gene family J Bioenerg Biomembr 33 2001 475 479
3. C. Duhem, F. Ries, and M. Dicato What does multidrug resistance (MDR) expression mean in the clinic' Oncologist 1 1996 151 158
4. X. Li, P. Li, Y. Zhang, Y. Zhou, X. Chen, and Y. Huang Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously Pharm Res 27 2010 1498 1511
5. S. Ganta, and M. Amiji Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells Mol Pharm 6 2009 928 939
6. J. Wu, Y. Lu, A. Lee, X. Pan, X. Yang, and X. Zhao Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil J Pharm Pharm Sci 10 3 2007 350 357
7. X.R. Song, Z. Cai, Y. Zheng, G. He, F.Y. Cui, and D.Q. Gong Reversion of multidrug resistance by co-encapsulation of vincristine and verapamil in PLGA nanoparticles Eur J Pharm Sci 37 2009 300 305
8. C.E. Soma, C. Dubernet, D. Bentolila, S. Benita, and P. Couvreur Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles Biomaterials 21 2000 1 7
9. F. Wang, D. Zhang, Q. Zhang, Y. Chen, D. Zheng, and L. Hao Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel-polymer micelles to overcome multi-drug resistance Biomaterials 32 2011 9444 9456
10. V. Torchilin Multifunctional and stimuli-sensitive pharmaceutical nanocarriers Eur J Pharm Biopharm 71 2009 431 444
11. A. Klaikherd, C. Nagamani, and S. Thayumanavan Multi-stimuli sensitive amphiphilic block copolymer assemblies J Am Chem Soc 131 2009 4830 4838
12. R. van Sluis, Z.M. Bhujwalla, N. Raghunand, P. Ballesteros, J. Alvarez, and S. Cerdan In vivo imaging of extracellular pH using 1H MRSI Magn Reson Med 41 1999 743 750
13. K. Engin, D.B. Leeper, J.R. Cater, A.J. Thistlethwaite, L. Tupchong, and J.D. McFarlane Extracellular pH distribution in human tumours Int J Hyperthermia 11 1995 211 216
14. E.S. Lee, K. Na, and Y.H. Bae Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor J Control Release 103 2005 405 418
15. C.H. Wang, and G.H. Hsiue New amphiphilic poly(2-ethyl-2-oxazoline)/poly(l-lactide) triblock copolymers Biomacromolecules 4 2003 1487 1490
16. J.M. Dintaman, and J.A. Silverman Inhibition of P-glycoprotein by d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) Pharm Res 16 1999 1550 1556
17. Y. Zhang, X. Li, Y. Zhou, Y. Fan, X. Wang, and Y. Huang Cyclosporin A-loaded poly(ethylene glycol)-b-poly(d,l-lactic acid) micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier Mol Pharm 7 2010 1169 1182
18. X. Wang, X. Li, Y. Li, Y. Zhou, C. Fan, and W. Li Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)-poly(d,l-lactide)-poly(2-ethyl-2-oxazoline) hydrogels Acta Biomater 7 2011 4149 4159
19. X. Li, Z. Yang, K. Yang, Y. Zhou, X. Chen, and Y. Zhang Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen Nanoscale Res Lett 4 2009 1502 1511
20. C.H. Wang, and G.H. Hsiue Polymeric micelles with a pH-responsive structure as intracellular drug carriers J Control Release 108 2005 140 149
21. Y.H. Jin, H.Y. Hu, M.X. Qiao, J. Zhu, J.W. Qi, and C.J. Hu PH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: preparation and in vitro evaluation Colloids Surf B Biointerfaces 94 2012 184 191
22. N. Li, X.-R. Li, Y.-X. Zhou, W.-J. Li, Y. Zhao, and S.-J. Ma The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier Biomaterials 33 2012 8881 8892
23. Z. Gao, A.N. Lukyanov, A. Singhal, and V.P. Torchilin Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs Nano Lett 2 2002 979 982
24. X. Duan, and Y. Li Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking Small 9 2013 1521 1532
25. Y.C. Chen, L.C. Liao, P.L. Lu, C.L. Lo, H.C. Tsai, and C.Y. Huang The accumulation of dual pH and temperature responsive micelles in tumors Biomaterials 33 2012 4576 4588
26. I. Akiba, Y. Ohba, and S. Akiyama Phase structure in blends of poly(ethylene glycol) and poly(styrene-co-methacrylic acid) Macromolecules 32 1999 1175 1179
27. C.F. Mu, P. Balakrishnan, F.D. Cui, Y.M. Yin, Y.B. Lee, and H.G. Choi The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel Biomaterials 31 2010 2371 2379
28. E.M. Collnot, C. Baldes, U.F. Schaefer, K.J. Edgar, M.F. Wempe, and C.M. Lehr Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access Mol Pharm 7 2010 642 651
29. A. Mahmud, and A. Lavasanifar The effect of block copolymer structure on the internalization of polymeric micelles by human breast cancer cells Colloids Surf B Biointerfaces 45 2005 82 89
30. W. Zhang, Y. Shi, Y. Chen, J. Ye, X. Sha, and X. Fang Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors Biomaterials 32 2011 2894 2906
31. Y. Wang, L. Yu, L. Han, X. Sha, and X. Fang Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines Int J Pharm 337 2007 63 73
32. W. Zhang, Y. Shi, Y. Chen, S. Yu, J. Hao, and J. Luo Enhanced antitumor efficacy by paclitaxel-loaded Pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance Eur J Pharm Biopharm 75 2010 341 353
33. A.V. Kabanov, E.V. Batrakova, and D.W. Miller Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier Adv Drug Deliv Rev 55 2003 151 164
34. M. Han, Y.Y. Diao, H.L. Jiang, X.Y. Ying, D.W. Chen, and W.Q. Liang Molecular mechanism study of chemosensitization of doxorubicin-resistant human myelogenous leukemia cells induced by a composite polymer micelle Int J Pharm 420 2011 404 411
35. H. Wu, L. Zhu, and V.P. Torchilin pH-sensitive poly(histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery Biomaterials 34 2013 1213 1222
36. C. Sanson, C. Schatz, J.F. Le Meins, A. Soum, J. Thevenot, and E. Garanger A simple method to achieve high doxorubicin loading in biodegradable polymersomes J Control Release 147 2010 428 435