PH-sensitive chitosan-derived nanoparticles as doxorubicin carriers for effective anti-tumor activity: Preparation and in vitro evaluation

Colloids and Surfaces B: Biointerfaces

Volumn 94, Issue , 2012, Pages 184-191

  Jin, Yun Huan ^a   Hu, Hai Yang ^a   Qiao, Ming Xi ^a   Zhu, Jia ^a   Qi, Jia Wei ^a   Hu, Chan Juan ^a   Zhang, Qiang ^b   Chen, Da Wei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Antitumor activity; Chitosan derivatives; Doxorubicin; Drug resistance; Nanoparticles; PH sensitive

Indexed keywords

ANTI-TUMOR ACTIVITIES; CHITOSAN DERIVATIVES; DOXORUBICIN; DRUG RESISTANCE; PH SENSITIVE;

CHITOSAN; CONFOCAL MICROSCOPY; DRUG PRODUCTS; FLOW CYTOMETRY; MULTILAYERS;

NANOPARTICLES;

CHITOSAN DERIVED NANOPARTICLE; DOXORUBICIN; NANOCARRIER; NANOPARTICLE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CELL STRAIN MCF 7; CHEMICAL MODIFICATION; CHEMICAL PHENOMENA; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEFORMATION BEHAVIOR; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG RETENTION; DRUG UPTAKE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PARTICLE SIZE; PH; PRIORITY JOURNAL; SELF AGGREGATION BEHAVIOR; SUSTAINED DRUG RELEASE; ZETA POTENTIAL;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CHITOSAN; DELAYED-ACTION PREPARATIONS; DEOXYCHOLIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG CARRIERS; DRUG RESISTANCE, NEOPLASM; FEMALE; FLOW CYTOMETRY; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, CONFOCAL; NANOPARTICLES; PARTICLE SIZE;

EID: 84862783028     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2012.01.032     Document Type: Article

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