-
1
-
-
78649364332
-
Hypoxia-inducible factors and the response to hypoxic stress
-
Majmundar, A. J., Wong, W. J., and Simon, M. C. (2010) Hypoxia-inducible factors and the response to hypoxic stress. Mol. Cell 40, 294-309
-
(2010)
Mol. Cell
, vol.40
, pp. 294-309
-
-
Majmundar, A.J.1
Wong, W.J.2
Simon, M.C.3
-
2
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza, G. L. (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148, 399-408
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
3
-
-
33846199233
-
Hypoxia-inducible factors: Central regulators of the tumor phenotype
-
Gordan, J. D., and Simon, M. C. (2007) Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr. Opin. Genet. Dev. 17, 71-77
-
(2007)
Curr. Opin. Genet. Dev.
, vol.17
, pp. 71-77
-
-
Gordan, J.D.1
Simon, M.C.2
-
4
-
-
0037117479
-
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
-
Freedman, S. J., Sun, Z. Y., Poy, F., Kung, A. L., Livingston, D. M., Wagner, G., and Eck, M. J. (2002) Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α. Proc. Natl. Acad. Sci. U.S.A. 99, 5367-5372
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 5367-5372
-
-
Freedman, S.J.1
Sun, Z.Y.2
Poy, F.3
Kung, A.L.4
Livingston, D.M.5
Wagner, G.6
Eck, M.J.7
-
5
-
-
67649306791
-
Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT)
-
Partch, C. L., Card, P. B., Amezcua, C. A., and Gardner, K. H. (2009) Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT). J. Biol. Chem. 284, 15184-15192
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 15184-15192
-
-
Partch, C.L.1
Card, P.B.2
Amezcua, C.A.3
Gardner, K.H.4
-
6
-
-
79956370722
-
Coactivators necessary for transcriptional output of the hypoxia-inducible factor, HIF, are directly recruited by ARNT PAS-B
-
Partch, C. L., and Gardner, K. H. (2011) Coactivators necessary for transcriptional output of the hypoxia-inducible factor, HIF, are directly recruited by ARNT PAS-B. Proc. Natl. Acad. Sci. U.S.A. 108, 7739-7744
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 7739-7744
-
-
Partch, C.L.1
Gardner, K.H.2
-
7
-
-
77951220423
-
Coactivator recruitment: A new role for PAS domains in transcriptional regulation by the bHLH-PAS family
-
Partch, C. L., and Gardner, K. H. (2010) Coactivator recruitment: a new role for PAS domains in transcriptional regulation by the bHLH-PAS family. J. Cell. Physiol. 223, 553-557
-
(2010)
J. Cell. Physiol.
, vol.223
, pp. 553-557
-
-
Partch, C.L.1
Gardner, K.H.2
-
8
-
-
9644257219
-
Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription
-
Kim, J. H., and Stallcup, M. R. (2004) Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription. J. Biol. Chem. 279, 49842-49848
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 49842-49848
-
-
Kim, J.H.1
Stallcup, M.R.2
-
9
-
-
11144232325
-
Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia
-
Beischlag, T. V., Taylor, R. T., Rose, D. W., Yoon, D., Chen, Y., Lee, W. H., Rosenfeld, M. G., and Hankinson, O. (2004) Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. J. Biol. Chem. 279, 54620-54628
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 54620-54628
-
-
Beischlag, T.V.1
Taylor, R.T.2
Rose, D.W.3
Yoon, D.4
Chen, Y.5
Lee, W.H.6
Rosenfeld, M.G.7
Hankinson, O.8
-
10
-
-
0343278978
-
Isolation and characterization of AINT: A novel ARNT interacting protein expressed during murine embryonic development
-
Sadek, C. M., Jalaguier, S., Feeney, E. P., Aitola, M., Damdimopoulos, A. E., Pelto-Huikko, M., and Gustafsson, J. A. (2000) Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development. Mech. Dev. 97, 13-26
-
(2000)
Mech. Dev.
, vol.97
, pp. 13-26
-
-
Sadek, C.M.1
Jalaguier, S.2
Feeney, E.P.3
Aitola, M.4
Damdimopoulos, A.E.5
Pelto-Huikko, M.6
Gustafsson, J.A.7
-
11
-
-
84865805666
-
Transforming fusions of FGFR and TACC genes in human glioblastoma
-
Singh, D., Chan, J. M., Zoppoli, P., Niola, F., Sullivan, R., Castano, A., Liu, E. M., Reichel, J., Porrati, P., Pellegatta, S., Qiu, K., Gao, Z., Ceccarelli, M., Riccardi, R., Brat, D. J., et al. (2012) Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337, 1231-1235
-
(2012)
Science
, vol.337
, pp. 1231-1235
-
-
Singh, D.1
Chan, J.M.2
Zoppoli, P.3
Niola, F.4
Sullivan, R.5
Castano, A.6
Liu, E.M.7
Reichel, J.8
Porrati, P.9
Pellegatta, S.10
Qiu, K.11
Gao, Z.12
Ceccarelli, M.13
Riccardi, R.14
Brat, D.J.15
-
12
-
-
0033082686
-
Overcoming expression and purification problems of RhoGDI using a family of "parallel"expression vectors
-
Sheffield, P., Garrard, S., and Derewenda, Z. (1999) Overcoming expression and purification problems of RhoGDI using a family of "parallel"expression vectors. Protein Expr. Purif. 15, 34-39
-
(1999)
Protein Expr. Purif.
, vol.15
, pp. 34-39
-
-
Sheffield, P.1
Garrard, S.2
Derewenda, Z.3
-
13
-
-
0141707094
-
Structural basis of a phototropin light switch
-
Harper, S. M., Neil, L. C., and Gardner, K. H. (2003) Structural basis of a phototropin light switch. Science 301, 1541-1544
-
(2003)
Science
, vol.301
, pp. 1541-1544
-
-
Harper, S.M.1
Neil, L.C.2
Gardner, K.H.3
-
14
-
-
0032568543
-
The structure of the Nterminus of striated muscle α-tropomyosin in a chimeric peptide: Nuclear magnetic resonance structure and circular dichroism studies
-
Greenfield, N. J., Montelione, G. T., Farid, R. S., and Hitchcock-DeGregori, S. E. (1998) The structure of the Nterminus of striated muscle α-tropomyosin in a chimeric peptide: nuclear magnetic resonance structure and circular dichroism studies. Biochemistry 37, 7834-7843
-
(1998)
Biochemistry
, vol.37
, pp. 7834-7843
-
-
Greenfield, N.J.1
Montelione, G.T.2
Farid, R.S.3
Hitchcock-DeGregori, S.E.4
-
15
-
-
33745933955
-
HKL-3000: The integration of data reduction and structure solution-from diffraction images to an initial model in minutes
-
Minor, W., Cymborowski, M., Otwinowski, Z., and Chruszcz, M. (2006) HKL-3000: the integration of data reduction and structure solution-from diffraction images to an initial model in minutes. Acta Crystallogr. D Biol. Crystallogr. 62, 859-866
-
(2006)
Acta Crystallogr. D Biol. Crystallogr.
, vol.62
, pp. 859-866
-
-
Minor, W.1
Cymborowski, M.2
Otwinowski, Z.3
Chruszcz, M.4
-
16
-
-
34447508216
-
Phaser crystallographic software
-
McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C., and Read, R. J. (2007) Phaser crystallographic software. J. Appl. Crystallogr. 40, 658-674
-
(2007)
J. Appl. Crystallogr.
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
Grosse-Kunstleve, R.W.2
Adams, P.D.3
Winn, M.D.4
Storoni, L.C.5
Read, R.J.6
-
17
-
-
84875201642
-
Regulating the ARNT/TACC3 axis: Multiple approaches to manipulating protein/protein interactions with small molecules
-
Guo, Y., Partch, C. L., Key, J., Card, P. B., Pashkov, V., Patel, A., Bruick, R. K., Wurdak, H., and Gardner, K. H. (2013) Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem. Biol. 8, 626-635
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 626-635
-
-
Guo, Y.1
Partch, C.L.2
Key, J.3
Card, P.B.4
Pashkov, V.5
Patel, A.6
Bruick, R.K.7
Wurdak, H.8
Gardner, K.H.9
-
18
-
-
78049479623
-
Joint x-ray and neutron refinement with phenix.refine
-
Afonine, P. V., Mustyakimov, M., Grosse-Kunstleve, R. W., Moriarty, N. W., Langan, P., and Adams, P. D. (2010) Joint x-ray and neutron refinement with phenix.refine. Acta Crystallogr. D Biol. Crystallogr. 66, 1153-1163
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 1153-1163
-
-
Afonine, P.V.1
Mustyakimov, M.2
Grosse-Kunstleve, R.W.3
Moriarty, N.W.4
Langan, P.5
Adams, P.D.6
-
19
-
-
74549178560
-
MolProbity: All-atom structure validation for macromolecular crystallography
-
Chen, V. B., Arendall, W. B., 3rd, Headd, J. J., Keedy, D. A., Immormino, R. M., Kapral, G. J., Murray, L. W., Richardson, J. S., and Richardson, D. C. (2010) MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 66, 12-21
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 12-21
-
-
Chen, V.B.1
Arendall, W.B.2
Headd, J.J.3
Keedy, D.A.4
Immormino, R.M.5
Kapral, G.J.6
Murray, L.W.7
Richardson, J.S.8
Richardson, D.C.9
-
20
-
-
58849141619
-
Artificial ligand binding within the HIF2αPAS-B domain of the HIF2 transcription factor
-
Scheuermann, T. H., Tomchick, D. R., Machius, M., Guo, Y., Bruick, R. K., and Gardner, K. H. (2009) Artificial ligand binding within the HIF2αPAS-B domain of the HIF2 transcription factor. Proc. Natl. Acad. Sci. U.S.A. 106, 450-455
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 450-455
-
-
Scheuermann, T.H.1
Tomchick, D.R.2
Machius, M.3
Guo, Y.4
Bruick, R.K.5
Gardner, K.H.6
-
21
-
-
77950798648
-
Recent developments in classical density modification
-
Cowtan, K. (2010) Recent developments in classical density modification. Acta Crystallogr. D Biol. Crystallogr. 66, 470-478
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 470-478
-
-
Cowtan, K.1
-
22
-
-
33748337934
-
The Buccaneer software for automated model building. 1. Tracing protein chains
-
Cowtan, K. (2006) The Buccaneer software for automated model building. 1. Tracing protein chains. Acta Crystallogr. D Biol. Crystallogr. 62, 1002-1011
-
(2006)
Acta Crystallogr. D Biol. Crystallogr.
, vol.62
, pp. 1002-1011
-
-
Cowtan, K.1
-
23
-
-
84889120137
-
Improved methods for building protein models in electron density maps and the location of errors in these models
-
Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119
-
(1991)
Acta Crystallogr. A
, vol.47
, pp. 110-119
-
-
Jones, T.A.1
Zou, J.Y.2
Cowan, S.W.3
Kjeldgaard, M.4
-
24
-
-
77949535720
-
Features and development of Coot
-
Emsley, P., Lohkamp, B., Scott, W. G., and Cowtan, K. (2010) Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66, 486-501
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
25
-
-
0346734132
-
Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor
-
Erbel, P. J., Card, P. B., Karakuzu, O., Bruick, R. K., and Gardner, K. H. (2003) Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor. Proc. Natl. Acad. Sci. U.S.A. 100, 15504-15509
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 15504-15509
-
-
Erbel, P.J.1
Card, P.B.2
Karakuzu, O.3
Bruick, R.K.4
Gardner, K.H.5
-
26
-
-
26244466162
-
Structural basis of ARNT PAS-B dimerization: Use of a common β-sheet interface for hetero- and homodimerization
-
Card, P. B., Erbel, P. J., and Gardner, K. H. (2005) Structural basis of ARNT PAS-B dimerization: use of a common β-sheet interface for hetero- and homodimerization. J. Mol. Biol. 353, 664-677
-
(2005)
J. Mol. Biol.
, vol.353
, pp. 664-677
-
-
Card, P.B.1
Erbel, P.J.2
Gardner, K.H.3
-
27
-
-
0029400480
-
NMRPipe: A multidimensional spectral processing system based on UNIX pipes
-
Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6, 277-293
-
(1995)
J. Biomol. NMR
, vol.6
, pp. 277-293
-
-
Delaglio, F.1
Grzesiek, S.2
Vuister, G.W.3
Zhu, G.4
Pfeifer, J.5
Bax, A.6
-
28
-
-
77955391393
-
The HADDOCK web server for data-driven biomolecular docking
-
de Vries, S. J., van Dijk, M., and Bonvin, A. M. (2010) The HADDOCK web server for data-driven biomolecular docking. Nat. Protoc. 5, 883-897
-
(2010)
Nat. Protoc.
, vol.5
, pp. 883-897
-
-
De Vries, S.J.1
Van Dijk, M.2
Bonvin, A.M.3
-
29
-
-
0026331267
-
X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil
-
O'Shea, E. K., Klemm, J. D., Kim, P. S., and Alber, T. (1991) X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science 254, 539-544
-
(1991)
Science
, vol.254
, pp. 539-544
-
-
O'Shea, E.K.1
Klemm, J.D.2
Kim, P.S.3
Alber, T.4
-
30
-
-
33646356250
-
Detecting transient intermediates in macromolecular binding by paramagnetic NMR
-
Iwahara, J., and Clore, G. M. (2006) Detecting transient intermediates in macromolecular binding by paramagnetic NMR. Nature 440, 1227-1230
-
(2006)
Nature
, vol.440
, pp. 1227-1230
-
-
Iwahara, J.1
Clore, G.M.2
-
31
-
-
33845917564
-
Why molecules move along a temperature gradient
-
Duhr, S., and Braun, D. (2006) Why molecules move along a temperature gradient. Proc. Natl. Acad. Sci. U.S.A. 103, 19678-19682
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 19678-19682
-
-
Duhr, S.1
Braun, D.2
-
32
-
-
84875443909
-
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
-
Scheuermann, T. H., Li, Q., Ma, H. W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., Tambar, U. K., Gardner, K. H., and Bruick, R. K. (2013) Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat. Chem. Biol. 9, 271-276
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 271-276
-
-
Scheuermann, T.H.1
Li, Q.2
Ma, H.W.3
Key, J.4
Zhang, L.5
Chen, R.6
Garcia, J.A.7
Naidoo, J.8
Longgood, J.9
Frantz, D.E.10
Tambar, U.K.11
Gardner, K.H.12
Bruick, R.K.13
-
33
-
-
84863751285
-
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex
-
Huang, N., Chelliah, Y., Shan, Y., Taylor, C. A., Yoo, S. H., Partch, C., Green, C. B., Zhang, H., and Takahashi, J. S. (2012) Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science 337, 189-194
-
(2012)
Science
, vol.337
, pp. 189-194
-
-
Huang, N.1
Chelliah, Y.2
Shan, Y.3
Taylor, C.A.4
Yoo, S.H.5
Partch, C.6
Green, C.B.7
Zhang, H.8
Takahashi, J.S.9
-
34
-
-
75549087826
-
COSMIC (the Catalogue of Somatic Mutations in Cancer): A resource to investigate acquired mutations in human cancer
-
Forbes, S. A., Tang, G., Bindal, N., Bamford, S., Dawson, E., Cole, C., Kok, C. Y., Jia, M., Ewing, R., Menzies, A., Teague, J. W., Stratton, M. R., and Futreal, P. A. (2010) COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer. Nucleic Acids Res. 38, D652-D657
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. D652-D657
-
-
Forbes, S.A.1
Tang, G.2
Bindal, N.3
Bamford, S.4
Dawson, E.5
Cole, C.6
Kok, C.Y.7
Jia, M.8
Ewing, R.9
Menzies, A.10
Teague, J.W.11
Stratton, M.R.12
Futreal, P.A.13
-
35
-
-
84874605449
-
Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor
-
Rogers, J. L., Bayeh, L., Scheuermann, T. H., Longgood, J., Key, J., Naidoo, J., Melito, L., Shokri, C., Frantz, D. E., Bruick, R. K., Gardner, K. H., MacMillan, J. B., and Tambar, U. K. (2013) Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J. Med. Chem. 56, 1739-1747
-
(2013)
J. Med. Chem.
, vol.56
, pp. 1739-1747
-
-
Rogers, J.L.1
Bayeh, L.2
Scheuermann, T.H.3
Longgood, J.4
Key, J.5
Naidoo, J.6
Melito, L.7
Shokri, C.8
Frantz, D.E.9
Bruick, R.K.10
Gardner, K.H.11
MacMillan, J.B.12
Tambar, U.K.13
|