Inhibitory effects of scutellarein on proliferation of human lung cancer A549 cells through ERK and NFκB mediated by the EGFR pathway

Chinese Journal of Physiology

Volumn 57, Issue 4, 2014, Pages 182-187

  Cheng, Chun Yuan ^a,b   Hu, Chao Chin ^a   Yang, Hui Ju ^b   Lee, Meng Chih ^a,c   Kao, Erl Shyh ^d  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^c Taichung Hospital   (Taiwan)

^d CHIENKUO TECHNOLOGY UNIVERSITY   (Taiwan)

Author keywords

Cyclooxygenase 2; Epidermal growth factor receptor; Extracellular signal regulated; Kinase; Nuclear factor B; Scutellarein

Indexed keywords

CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; SCUTELLAREIN; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTINEOPLASTIC AGENT; APIGENIN; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; EGFR PROTEIN, RAT; ENZYME INHIBITOR; LEUPEPTIN; NITRILE;

A549 CELL LINE; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; LUNG CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; CHEMISTRY; DRUG EFFECTS; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APIGENIN; BUTADIENES; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LEUPEPTINS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; NITRILES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84925286792     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: 10.4077/CJP.2014.BAC200     Document Type: Article

References (26)

1. Beei, C., Iwamoto, N., Inaba, T., Shinkai, Y. and Kumagai, Y. Activation of EGFR/MEK/ERK/AP-1 signaling mediated by 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary A549 cells. J. Toxicol. Sci. 38: 793-797, 2013.
2. Chang, W.S., Yang, M.D., Tsai, C.W., Cheng, L.H., Jeng, L.B., Lo, W.C., Lin, C.H., Huang, C.Y. and Bau, D.T. Association of cyclooxygenase 2 single-nucleotide polymorphisms and hepatocellular carcinoma in Taiwan. Chinese J. Physiol. 55: 1-7, 2012.
3. Chen, D., Wan, S.B., Yang, H., Yuan, J., Chan, T.H. and Dou, Q.P. EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment. Adv. Clin. Chem. 53: 155-177, 2011.
4. Chen, J., Zhao, M., Rao, R., Inoue, H. and Hao, C.M. C/EBPβ and its binding element are required for NFκB-induced COX2 expression following hypertonic stress. J. Biol. Chem. 280: 16354-16359, 2005.
5. Goh, D., Lee, Y.H. and Ong, E.S. Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. J. Agric. Food Chem. 53: 8197-8204, 2005.
6. Huang, R.Y. and Chen, G.G. Cigarette smoking, cyclooxygenase-2 pathway and cancer. Biochimica. et. Biophysica. Acta 1815: 158-169, 2011.
7. Indra, M.R., Karyono, S., Ratnawati, R. and Malik, S.G. Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in leptin-induced human umbilical vein endothelial cells (HUVECs). BMC. Res. Notes 6: 275, 2013 [Epub ahead of print].
8. Ikari, A., Sato, T., Watanabe, R., Yamazaki, Y. and Sugatani, J. Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells. Biochim. Biophys. Acta 1823: 1110-1118, 2012.
9. Kastamoulas, M., Chondrogiannis, G., Kanavaros, P., Vartholomatos, G., Bai, M., Briasoulis, E., Arvanitis, D. and Galani, V. Cytokine effects on cell survival and death of A549 lung carcinoma cells. Cytokine 61: 816-825, 2013.
10. Masmoudi, A., Chevalier, T.L., Sabatier, L. and Soria, J.C. Cyclooxygenase 2 inhibitors and cancer chemoprevention. Bull. Cancer 91: S77-S84, 2004.
11. Martinez-Outschoorn, U.E., Curry, J.M., Ko, Y.H., Lin, Z., Tuluc, M., Cognetti, D., Birbe, R.C., Pribitkin, E., Bombonati, A., Pestell, R.G., Howell, A., Sotgia, F. and Lisanti, M.P. Oncogenes and in-flammation rewire host energy metabolism in the tumor microenvironment: RAS and NFkB target stromal MCT4. Cell Cycle 12: 2580-2597, 2013.
12. Okada, M., Shibuya, K., Sato, A., Seino, S., Watanabe, E., Suzuki, S., Seino, M. and Kitanaka, C. Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells. Oncol. Rep. 30: 1957-1964, 2013.
13. Prado, S.M., Cedrún, J.L., Rey, R.L., Villaamil, V.M., García, A.A., Ayerbes, M.V. and Aparicio, L.A. Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias. Exp. Mol. Pathol. 89: 197-203, 2010.
14. Priyadarsini, R.V., Vinothini, G., Murugan, R.S., Manikandan, P. and Nagini, S. The flavonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutr. Cancer 63: 218-226, 2011.
15. Sabri, A., Ziaee, A.A., Ostad, S.N., Alimoghadam, K. and Ghahremani, M.H. Crosstalk of EGF-directed MAPK signalling pathways and its potential role on EGF-induced cell proliferation and COX-2 expression in human mesenchymal stem cells. Cell Biochem. Funct. 29: 64-70, 2011.
16. Silvina, B. and Lotito, B.F. Dietary flavonoids attenuate tumor necrosis factor α-induced adhesion molecule expression in human aortic endothelial cells. J. Biol. Chem. 281: 37102-37110, 2006.
17. Stefek, M. Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract. Interdiscip. Toxicol. 4: 69-77, 2011.
18. Takai, E., Tsukimoto, M. and Kojima, S. TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, Which is involved in fibrotic response to TGF-β1. PLoS One 8: e76346, 2013.
19. Tsai, W.C., Lin, C.K., Lee, H.S., Chen, A., Nieh, S., Yu, C.P., Wu, C.C., Jao, S.W. and Jin, J.S. Discordance between EGFR expression and clinicopathologic parameters of colorectal adenocarcinoma in Taiwan. Chinese J. Physiol. 55: 352-360, 2012.
20. Tsai, W.C., Tsai, W.C., Lee, H.S., Jin, J.S., Gao, H.W., Chao, T.K., Chen, A., Nieh, S., Chan, D.C., Chang, F.N. and Lin, C.K. Association between osteopontin and EGFR expression with clinicopathological parameters in hepatocellular Carcinoma. Chinese J. Physiol. 55: 412-420, 2012.
21. Wang, Y., Ao, H., Qian, Z. and Zheng, Y. Intestinal transport of scutellarein and scutellarin and first-pass metabolism by UDPglucuronosyltransferase-mediated glucuronidation of scutellarein and hydrolysis of scutellarin. Xenobiotica 41: 538-548, 2011.
22. Wei, L., Lin, J., Xu, W., Cai, Q., Shen, A., Hong, Z. and Peng, J. Scutellaria barbata D. Don inhibits tumor angiogenesis via suppression of hedgehog pathway in a mouse model of colorectal cancer. Int. J. Mol. Sci. 13: 9419-9430, 2012.
23. Wei, J., Yan, W., Li, X., Chang, W.C. and Tai, H.H. Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells. Biochem. Pharmacol. 74: 787-800, 2007.
24. Yadav, V.R., Prasad, S., Sung, B. and Aggarwal, B.B. The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. Int. Immunopharmacol. 11: 295-309, 2011.
25. Zheng, C.D., Li, G., Li, H.Q., Xu, X.J., Gao, J.M. and Zhang, A.L. DPPH-scavenging activities and structure-activity relationships of phenolic compounds. Nat. Prod. Commun. 5: 1759-1765, 2010.
26. Zheng, C.Y., Xiao, W., Zhu, M.X., Pan, X.J., Yang, Z.H. and Zhou, S.Y. Inhibition of cyclooxygenase-2 by tetramethylpyrazine and its effects on A549 cell invasion and metastasis. Int. J. Oncol. 40: 2029-2037, 2012.