Activation of EGFR/MEK/ERK/AP-1 signaling mediated by 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary A549 cells

Journal of Toxicological Sciences

Volumn 38, Issue 5, 2013, Pages 793-797

  Beei, Chang ^a   Iwamoto, Noriko ^a   Inaba, Takako ^a   Shinkai, Yasuhiro ^a   Kumagai, Yoshito ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Covalent modification; EGFR; Electrophile; Signal transduction

Indexed keywords

1,2 NAPHTHOQUINONE; ELECTROPHILE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; TRANSCRIPTION FACTOR AP 1;

AUTOPHOSPHORYLATION; CELL ACTIVITY; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; LETTER; LUNG ALVEOLUS CELL; NUCLEIC ACID ANALYSIS; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AIR POLLUTANTS; CELLS, CULTURED; DNA; HUMANS; MAP KINASE SIGNALING SYSTEM; NAPHTHOQUINONES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84885985714     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.38.793     Document Type: Letter

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